Structure of the HIV-1 Integrase Catalytic Domain Complexed with an Inhibitor: A Platform for Antiviral Drug Design
Goldgur, Yehuda, Craigie, Robert, Cohen, Gerson H., Fujiwara, Tamio, Yoshinaga, Tomokazu, Fujishita, Toshio, Sugimoto, Hirohiko, Endo, Takeshi, Murai, Hitoshi, Davies, David R.
Published in Proceedings of the National Academy of Sciences - PNAS (09.11.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (09.11.1999)
Get full text
Journal Article
Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants
Kobayashi, Masanori, Nakahara, Koichiro, Seki, Takahiro, Miki, Shigeru, Kawauchi, Shinobu, Suyama, Akemi, Wakasa-Morimoto, Chiaki, Kodama, Makoto, Endoh, Takeshi, Oosugi, Eiichi, Matsushita, Yoshihiro, Murai, Hitoshi, Fujishita, Toshio, Yoshinaga, Tomokazu, Garvey, Edward, Foster, Scott, Underwood, Mark, Johns, Brian, Sato, Akihiko, Fujiwara, Tamio
Published in Antiviral research (01.11.2008)
Published in Antiviral research (01.11.2008)
Get full text
Journal Article
Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzo[a,d]cycloheptene and Dibenzo[b,f]oxepin Derivatives. Searching for Bioisosteres of Biphenyltetrazole Using a Three-Dimensional Search Technique
Kiyama, Ryuichi, Honma, Tsunetoshi, Hayashi, Kunio, Ogawa, Masayoshi, Hara, Mariko, Fujimoto, Masafumi, Fujishita, Toshio
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
Get full text
Journal Article
Secondary mutations in viruses resistant to HIV-1 integrase inhibitors that restore viral infectivity and replication kinetics
Nakahara, Koichiro, Wakasa-Morimoto, Chiaki, Kobayashi, Masanori, Miki, Shigeru, Noshi, Takeshi, Seki, Takahiro, Kanamori-Koyama, Mikiko, Kawauchi, Shinobu, Suyama, Akemi, Fujishita, Toshio, Yoshinaga, Tomokazu, Garvey, Edward P., Johns, Brian A., Foster, Scott A., Underwood, Mark R., Sato, Akihiko, Fujiwara, Tamio
Published in Antiviral research (01.02.2009)
Published in Antiviral research (01.02.2009)
Get full text
Journal Article
Enzymology of a carbonyl reduction clearance pathway for the HIV integrase inhibitor, S-1360: role of human liver cytosolic aldo-keto reductases
Rosemond, M.Jane Cox, St. John-Williams, Lisa, Yamaguchi, Toshiro, Fujishita, Toshio, Walsh, John S
Published in Chemico-biological interactions (15.03.2004)
Published in Chemico-biological interactions (15.03.2004)
Get full text
Journal Article
Synthesis and Evaluation of Novel Pyrazolo[1, 5-a]pyrimidine Derivatives as Nonpeptide Angiotensin II Receptor Antagonists
KIYAMA, Ryuichi, HAYASHI, Kunio, HARA, Mariko, FUJIMOTO, Masafumi, KAWABATA, Tomoji, KAWAKAMI, Masaru, NAKAJIMA, Shigeyuki, FUJISHITA, Toshio
Published in Chemical & pharmaceutical bulletin (1995)
Published in Chemical & pharmaceutical bulletin (1995)
Get full text
Journal Article
SUBSTITUTED 3-HYDROXY-4-PYRIDONE DERIVATIVE
FUJISHITA, TOSHIO, KAWAI, MAKOTO, AKIYAMA, TOSHIYUKI, MIKAMIYAMA, MINAKO
Year of Publication 30.09.2010
Get full text
Year of Publication 30.09.2010
Patent
ANTIVIRAL AGENT
TADA YUKIO, FUJISHITA TOSHIO, KAWASUJI TAKASHI, TAKECHI SHOZO, FUJI MASAHIRO, KIYAMA RYUICHI, KANDA YASUHIKO
Year of Publication 03.08.2010
Get full text
Year of Publication 03.08.2010
Patent
FUSED HETEROCYCLIC COMPOUND HAVING ANTI-HCV EFFECT
FUJISHITA, TOSHIO, ENDOH, TAKESHI, NAITO, AKIRA, ABE, KENJI, MATSUMOTO, HIROSHI, ONODERA, NAOHIRO, IWATA, MINAKO, MAKINO, ITSUO
Year of Publication 22.12.2005
Get full text
Year of Publication 22.12.2005
Patent
Novel angiotensin II receptor antagonists. Design, synthesis, and in vitro evaluation of dibenzo[a,d]cycloheptene and dibenzo[b,f]oxepin derivatives. Searching for bioisosteres of biphenylyltetrazole using a three-dimensional search technique
KIYAMA, R, HONMA, T, HAYASHI, K, OGAWA, M, HARA, M, FUJIMOTO, M, FUJISHITA, T
Published in Journal of medicinal chemistry (07.07.1995)
Published in Journal of medicinal chemistry (07.07.1995)
Get full text
Journal Article
ANTIVIRAL AGENT
TAKECHI, SHOZO, KIYAMA, RYUICHI, KANDA, YASUHIKO, FUJI, MASAHIRO, TADA, YUKIO, FUJISHITA, TOSHIO, KAWASUJI, TAKASHI
Year of Publication 27.02.2003
Get full text
Year of Publication 27.02.2003
Patent
2-SUBSTITUTED CARBONYLIMIDAZO £4,5-C|QUINOLINES
FUJISHITA, TOSHIO, TAKADA, SUSUMU, MATSUSHITA, AKIRA, EIGYO, MASAMI, SASATANI, TAKASHI
Year of Publication 15.04.1997
Get full text
Year of Publication 15.04.1997
Patent
Synthesis and Structure−Activity Relationships of Fused Imidazopyridines: A New Series of Benzodiazepine Receptor Ligands
Takada, Susumu, Sasatani, Takashi, Chomei, Nobuo, Adachi, Makoto, Fujishita, Toshio, Eigyo, Masami, Murata, Shunji, Kawasaki, Kazuo, Matsushita, Akira
Published in Journal of medicinal chemistry (05.07.1996)
Published in Journal of medicinal chemistry (05.07.1996)
Get full text
Journal Article
ANTIVIRAL AGENT
MASAHIRO FUJI, YASUHIKO KANDA, SHOZO TAKECHI, YUKIO TADA, TAKASHI KAWASUJI, RYUICHI KIYAMA, TOSHIO FUJISHITA
Year of Publication 10.05.2017
Get full text
Year of Publication 10.05.2017
Patent
Antiviral agent
Fujishita, Toshio, Takechi, Shozo, Tada, Yukio, Kanda, Yasuhiko, Fuji, Masahiro, Kiyama, Ryuichi, Kawasuji, Takashi
Year of Publication 15.03.2017
Get full text
Year of Publication 15.03.2017
Patent
ANTIVIRAL AGENT
KIYAMA Ryuichi, FUJI Masahiro, TAKECHI Shozo, KANDA Yasuhiko, TADA Yukio, FUJISHITA Toshio, KAWASUJI Takashi
Year of Publication 09.03.2017
Get full text
Year of Publication 09.03.2017
Patent