Atropisomerism – A Neglected Way to Escape Out of Solubility Flatlands
Saal, Christoph, Becker, Axel, Krier, Mireille, Fuchß, Thomas
Published in Journal of pharmaceutical sciences (01.01.2022)
Published in Journal of pharmaceutical sciences (01.01.2022)
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Journal Article
Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Zenke, Frank T, Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Kirkin, Vladimir, Pehl, Ulrich, Grombacher, Thomas, Wilm, Claudia, Fuchss, Thomas, Amendt, Christiane, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.05.2020)
Published in Molecular cancer therapeutics (01.05.2020)
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Journal Article
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects
Schindler, Christina E. M, Baumann, Hannah, Blum, Andreas, Böse, Dietrich, Buchstaller, Hans-Peter, Burgdorf, Lars, Cappel, Daniel, Chekler, Eugene, Czodrowski, Paul, Dorsch, Dieter, Eguida, Merveille K. I, Follows, Bruce, Fuchß, Thomas, Grädler, Ulrich, Gunera, Jakub, Johnson, Theresa, Jorand Lebrun, Catherine, Karra, Srinivasa, Klein, Markus, Knehans, Tim, Koetzner, Lisa, Krier, Mireille, Leiendecker, Matthias, Leuthner, Birgitta, Li, Liwei, Mochalkin, Igor, Musil, Djordje, Neagu, Constantin, Rippmann, Friedrich, Schiemann, Kai, Schulz, Robert, Steinbrecher, Thomas, Tanzer, Eva-Maria, Unzue Lopez, Andrea, Viacava Follis, Ariele, Wegener, Ansgar, Kuhn, Daniel
Published in Journal of chemical information and modeling (23.11.2020)
Published in Journal of chemical information and modeling (23.11.2020)
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Journal Article
An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization
Rial-Rodríguez, Eduardo, Williams, Jason D, Cantillo, David, Fuchß, Thomas, Sommer, Alena, Eggenweiler, Hans-Michael, Kappe, C Oliver, Laudadio, Gabriele
Published in Angewandte Chemie International Edition (07.11.2024)
Published in Angewandte Chemie International Edition (07.11.2024)
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Journal Article
A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors
Buchstaller, Hans-Peter, Sala-Hojman, Ada, Leiendecker, Matthias, Albers, Joachim, Anlauf, Uwe, Berges, Nina, Dong, Liming, Fuchß, Thomas, Germann, Martina, Knehans, Tim, Krier, Mireille, Lecomte, Marc, Müller, Daniel, Müller, Sandra R., Leuthner, Birgitta, Lindemann, Ralph, Musil, Djordje, Nowak, Mateusz, Reither, Vivian, Rettig, Corinna, Schindler, Christina E. M., Pakulska, Urszula, Spuck, Dieter, Wegener, Ansgar, Zarębski, Adrian
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Journal Article
EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency
Ackermann, Teresa F., Boini, Krishna M., Beier, Norbert, Scholz, Wolfgang, Fuchß, Thomas, Lang, Florian
Published in Cellular physiology and biochemistry (01.01.2011)
Published in Cellular physiology and biochemistry (01.01.2011)
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Journal Article
Inhibition of Colonic Tumor Growth by the Selective SGK Inhibitor EMD638683
Towhid, Syeda T., Liu, Gui-Lai, Ackermann, Teresa F., Beier, Norbert, Scholz, Wolfgang, Fuchß, Thomas, Toulany, Mahmoud, Rodemann, Hans-Peter, Lang, Florian
Published in Cellular physiology and biochemistry (01.01.2013)
Published in Cellular physiology and biochemistry (01.01.2013)
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Journal Article
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights
Grädler, Ulrich, Fuchß, Thomas, Ulrich, Wolf-Rüdiger, Boer, Rainer, Strub, Andreas, Hesslinger, Christian, Anézo, Céline, Diederichs, Kay, Zaliani, Andrea
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
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Journal Article
The Novel Imidazopyridine 2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) Is a Highly Selective Inhibitor of the Inducible Nitric-Oxide Synthase
Strub, Andreas, Ulrich, Wolf-Rüdiger, Hesslinger, Christian, Eltze, Manfrid, Fuchss, Thomas, Strassner, Jochen, Strand, Susanne, Lehner, Martin D, Boer, Rainer
Published in Molecular pharmacology (01.01.2006)
Published in Molecular pharmacology (01.01.2006)
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Journal Article
Reiterative Chiral Resolution/Racemization/Recycle (RRR Synthesis) for an Effective and Scalable Process for the Enantioselective Synthesis of a Dual IDO1/TDO2 Inhibitor Imidazoisoindole Derivative
Crescenzi, Cristina, Fuchss, Thomas, Ippoliti, Dimitri, Langella, Annunziata, Di Mola, Antonia, Massa, Antonio, Rozzi, Diego
Published in Organic process research & development (19.06.2020)
Published in Organic process research & development (19.06.2020)
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Journal Article
Abstract 329: Highly potent and selective ATM kinase inhibitor M3541: A clinical candidate drug with strong antitumor activity in combination with radiotherapy
Fuchss, Thomas, Mederski, Werner W., Zenke, Frank T., Dahmen, Heike, Zimmermann, Astrid, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 3500: Highly potent and selective ATM kinase inhibitor M4076: A clinical candidate drug with strong anti-tumor activity in combination therapies
Fuchss, Thomas, Graedler, Ulrich, Schiemann, Kai, Kuhn, Daniel, Kubas, Holger, Dahmen, Heike, Zimmermann, Astrid, Zenke, Frank, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i)
Klein, Markus, Busch, Michael, Friese-Hamim, Manja, Crosignani, Stefano, Fuchss, Thomas, Musil, Djordje, Rohdich, Felix, Sanderson, Michael P, Seenisamy, Jeyaprakashnarayanan, Walter-Bausch, Gina, Zanelli, Ugo, Hewitt, Philip, Esdar, Christina, Schadt, Oliver
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
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Journal Article
An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization
Rial‐Rodríguez, Eduardo, Williams, Jason D., Cantillo, David, Fuchß, Thomas, Sommer, Alena, Eggenweiler, Hans‐Michael, Kappe, C. Oliver, Laudadio, Gabriele
Published in Angewandte Chemie (06.11.2024)
Published in Angewandte Chemie (06.11.2024)
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Journal Article
Abstract 338: A new investigational ATM Inhibitor, M3541, synergistically potentiates fractionated radiotherapy and chemotherapy in cancer cells and animal models
Zimmermann, Astrid, Zenke, Frank, Dahmen, Heike, Sirrenberg, Christian, Grombacher, Thomas, Vassilev, Lyubomir T., Fuchss, Thomas, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 1658: M3814, a novel investigational DNA-PK inhibitor: enhancing the effect of fractionated radiotherapy leading to complete regression of tumors in mice
Zenke, Frank T., Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Vassilev, Lubo, Pehl, Ulrich, Fuchss, Thomas, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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