A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
Kofink, Christiane, Trainor, Nicole, Mair, Barbara, Wöhrle, Simon, Wurm, Melanie, Mischerikow, Nikolai, Roy, Michael J., Bader, Gerd, Greb, Peter, Garavel, Géraldine, Diers, Emelyne, McLennan, Ross, Whitworth, Claire, Vetma, Vesna, Rumpel, Klaus, Scharnweber, Maximilian, Fuchs, Julian E., Gerstberger, Thomas, Cui, Yunhai, Gremel, Gabriela, Chetta, Paolo, Hopf, Stefan, Budano, Nicole, Rinnenthal, Joerg, Gmaschitz, Gerhard, Mayer, Moriz, Koegl, Manfred, Ciulli, Alessio, Weinstabl, Harald, Farnaby, William
Published in Nature communications (10.10.2022)
Published in Nature communications (10.10.2022)
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Journal Article
Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response
Reintjes, Anja, Fuchs, Julian E., Kremser, Leopold, Lindner, Herbert H., Liedl, Klaus R., Huber, Lukas A., Valovka, Taras
Published in Proceedings of the National Academy of Sciences - PNAS (19.04.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (19.04.2016)
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Journal Article
The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101
Ackaert, Chloé, Kofler, Stefan, Horejs-Hoeck, Jutta, Zulehner, Nora, Asam, Claudia, von Grafenstein, Susanne, Fuchs, Julian E, Briza, Peter, Liedl, Klaus R, Bohle, Barbara, Ferreira, Fátima, Brandstetter, Hans, Oostingh, Gertie J, Duschl, Albert
Published in PloS one (15.08.2014)
Published in PloS one (15.08.2014)
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Journal Article
Matched Molecular Pair Analysis: Significance and the Impact of Experimental Uncertainty
Kramer, Christian, Fuchs, Julian E, Whitebread, Steven, Gedeck, Peter, Liedl, Klaus R
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
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Journal Article
Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen
Machado, Yoan, MSc, Freier, Regina, MSc, Scheiblhofer, Sandra, PhD, Thalhamer, Theresa, PhD, Mayr, Melissa, BSc, Briza, Peter, PhD, Grutsch, Sarina, PhD, Ahammer, Linda, MSc, Fuchs, Julian E., PhD, Wallnoefer, Hannes G., PhD, Isakovic, Almedina, MSc, Kohlbauer, Vera, MSc, Hinterholzer, Arthur, BSc, Steiner, Markus, MSc, Danzer, Martin, MSc, Horejs-Hoeck, Jutta, PhD, Ferreira, Fatima, PhD, Liedl, Klaus R., PhD, Tollinger, Martin, PhD, Lackner, Peter, PhD, Johnson, Christopher M., PhD, Brandstetter, Hans, PhD, Thalhamer, Josef, PhD, Weiss, Richard, PhD
Published in Journal of allergy and clinical immunology (01.05.2016)
Published in Journal of allergy and clinical immunology (01.05.2016)
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Journal Article
Ligand Binding Modulates the Structural Dynamics and Compactness of the Major Birch Pollen Allergen
Grutsch, Sarina, Fuchs, Julian E., Freier, Regina, Kofler, Stefan, Bibi, Marium, Asam, Claudia, Wallner, Michael, Ferreira, Fátima, Brandstetter, Hans, Liedl, Klaus R., Tollinger, Martin
Published in Biophysical journal (16.12.2014)
Published in Biophysical journal (16.12.2014)
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Journal Article
Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity
Baburajeev, C P, Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Mason, Daniel J, Fuchs, Julian E, Bender, Andreas, Barash, Uri, Vlodavsky, Israel, Basappa, Rangappa, Kanchugarakoppal S
Published in BMC cancer (31.03.2017)
Published in BMC cancer (31.03.2017)
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Journal Article
Localization of Millisecond Dynamics: Dihedral Entropy from Accelerated MD
Kamenik, Anna S, Kahler, Ursula, Fuchs, Julian E, Liedl, Klaus R
Published in Journal of chemical theory and computation (09.08.2016)
Published in Journal of chemical theory and computation (09.08.2016)
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Journal Article
Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family
Stemeseder, Teresa, MSc, Freier, Regina, PhD, Wildner, Sabrina, MSc, Fuchs, Julian E., PhD, Briza, Peter, PhD, Lang, Roland, PhD, Batanero, Eva, PhD, Lidholm, Jonas, PhD, Liedl, Klaus R., PhD, Campo, Paloma, MD, PhD, Hawranek, Thomas, MD, Villalba, Mayte, PhD, Brandstetter, Hans, PhD, Ferreira, Fatima, PhD, Gadermaier, Gabriele, PhD
Published in Journal of allergy and clinical immunology (01.07.2017)
Published in Journal of allergy and clinical immunology (01.07.2017)
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Journal Article
Characterizing Protease Specificity: How Many Substrates Do We Need?
Schauperl, Michael, Fuchs, Julian E, Waldner, Birgit J, Huber, Roland G, Kramer, Christian, Liedl, Klaus R
Published in PloS one (11.11.2015)
Published in PloS one (11.11.2015)
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Journal Article
Electrostatic recognition in substrate binding to serine proteases
Waldner, Birgit J., Kraml, Johannes, Kahler, Ursula, Spinn, Alexander, Schauperl, Michael, Podewitz, Maren, Fuchs, Julian E., Cruciani, Gabriele, Liedl, Klaus R.
Published in Journal of molecular recognition (01.10.2018)
Published in Journal of molecular recognition (01.10.2018)
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Journal Article
A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A2
Anilkumar, Nirvanappa C, Sundaram, Mahalingam S, Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Bulusu, Krishna C, Fuchs, Julian E, Girish, Kesturu S, Bender, Andreas, Basappa, Rangappa, Kanchugarakoppal S
Published in PloS one (21.07.2015)
Published in PloS one (21.07.2015)
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Journal Article
A Nano-MgO and Ionic Liquid-Catalyzed 'Green' Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51)
Anusha, Sebastian, Cp, Baburajeev, Mohan, Chakrabhavi Dhananjaya, Mathai, Jessin, Rangappa, Shobith, Mohan, Surender, Chandra, Paricharak, Shardul, Mervin, Lewis, Fuchs, Julian E, M, Mahedra, Bender, Andreas, Basappa, Rangappa, Kanchugarakoppal S
Published in PloS one (15.10.2015)
Published in PloS one (15.10.2015)
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Journal Article
Pharmacological Targets of Kaempferol Within Inflammatory Pathways-A Hint Towards the Central Role of Tryptophan Metabolism
Hofer, Stefanie, Geisler, Simon, Lisandrelli, Rebecca, Nguyen Ngoc, Hieu, Ganzera, Markus, Schennach, Harald, Fuchs, Dietmar, Fuchs, Julian E, Gostner, Johanna M, Kurz, Katharina
Published in Antioxidants (21.02.2020)
Published in Antioxidants (21.02.2020)
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Journal Article
Independent Metrics for Protein Backbone and Side-Chain Flexibility: Time Scales and Effects of Ligand Binding
Fuchs, Julian E, Waldner, Birgit J, Huber, Roland G, von Grafenstein, Susanne, Kramer, Christian, Liedl, Klaus R
Published in Journal of chemical theory and computation (10.03.2015)
Published in Journal of chemical theory and computation (10.03.2015)
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Journal Article
Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase
Watschinger, Katrin, Fuchs, Julian E, Yarov-Yarovoy, Vladimir, Keller, Markus A, Golderer, Georg, Hermetter, Albin, Werner-Felmayer, Gabriele, Hulo, Nicolas, Werner, Ernst R
Published in Biochemical journal (01.04.2012)
Published in Biochemical journal (01.04.2012)
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Journal Article
Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulation
Fuchs, Julian E, Huber, Roland G, von Grafenstein, Susanne, Wallnoefer, Hannes G, Spitzer, Gudrun M, Fuchs, Dietmar, Liedl, Klaus R
Published in PloS one (31.12.2012)
Published in PloS one (31.12.2012)
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Journal Article