Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease
Liu, Chia-Chen, Tsai, Chih-Wei, Deak, Ferenc, Rogers, Justin, Penuliar, Michael, Sung, You Me, Maher, James N, Fu, Yuan, Li, Xia, Xu, Huaxi, Estus, Steven, Hoe, Hyang-Sook, Fryer, John D, Kanekiyo, Takahisa, Bu, Guojun
Published in Neuron (Cambridge, Mass.) (01.10.2014)
Published in Neuron (Cambridge, Mass.) (01.10.2014)
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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
Atagi, Yuka, Liu, Chia-Chen, Painter, Meghan M., Chen, Xiao-Fen, Verbeeck, Christophe, Zheng, Honghua, Li, Xia, Rademakers, Rosa, Kang, Silvia S., Xu, Huaxi, Younkin, Steven, Das, Pritam, Fryer, John D., Bu, Guojun
Published in The Journal of biological chemistry (23.10.2015)
Published in The Journal of biological chemistry (23.10.2015)
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Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
Kang, Silvia S, Ebbert, Mark T W, Baker, Kelsey E, Cook, Casey, Wang, Xuewei, Sens, Jonathon P, Kocher, Jeanne-Pierre, Petrucelli, Leonard, Fryer, John D
Published in The Journal of experimental medicine (03.09.2018)
Published in The Journal of experimental medicine (03.09.2018)
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Soluble TREM2 induces inflammatory responses and enhances microglial survival
Zhong, Li, Chen, Xiao-Fen, Wang, Tingting, Wang, Zhe, Liao, Chunyan, Wang, Zongqi, Huang, Ruizhi, Wang, Daxin, Li, Xinxiu, Wu, Linbei, Jia, Lin, Zheng, Honghua, Painter, Meghan, Atagi, Yuka, Liu, Chia-Chen, Zhang, Yun-Wu, Fryer, John D, Xu, Huaxi, Bu, Guojun
Published in The Journal of experimental medicine (06.03.2017)
Published in The Journal of experimental medicine (06.03.2017)
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Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Zhang, Yong-Jie, Gendron, Tania F., Ebbert, Mark T. W., O’Raw, Aliesha D., Yue, Mei, Jansen-West, Karen, Zhang, Xu, Prudencio, Mercedes, Chew, Jeannie, Cook, Casey N., Daughrity, Lillian M., Tong, Jimei, Song, Yuping, Pickles, Sarah R., Castanedes-Casey, Monica, Kurti, Aishe, Rademakers, Rosa, Oskarsson, Bjorn, Dickson, Dennis W., Hu, Wenqian, Gitler, Aaron D., Fryer, John D., Petrucelli, Leonard
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology
Chen, Fading, Swartzlander, Dan B, Ghosh, Anamitra, Fryer, John D, Wang, Baiping, Zheng, Hui
Published in Molecular neurodegeneration (31.01.2021)
Published in Molecular neurodegeneration (31.01.2021)
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Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight
Ebbert, Mark T W, Jensen, Tanner D, Jansen-West, Karen, Sens, Jonathon P, Reddy, Joseph S, Ridge, Perry G, Kauwe, John S K, Belzil, Veronique, Pregent, Luc, Carrasquillo, Minerva M, Keene, Dirk, Larson, Eric, Crane, Paul, Asmann, Yan W, Ertekin-Taner, Nilufer, Younkin, Steven G, Ross, Owen A, Rademakers, Rosa, Petrucelli, Leonard, Fryer, John D
Published in Genome Biology (20.05.2019)
Published in Genome Biology (20.05.2019)
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Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice
Allen, Jacob M, Berg Miller, Margret E, Pence, Brandt D, Whitlock, Keith, Nehra, Vandana, Gaskins, H Rex, White, Bryan A, Fryer, John D, Woods, Jeffrey A
Published in Journal of applied physiology (1985) (15.04.2015)
Published in Journal of applied physiology (1985) (15.04.2015)
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Large-scale topology and the default mode network in the mouse connectome
Stafford, James M., Jarrett, Benjamin R., Miranda-Dominguez, Oscar, Mills, Brian D., Cain, Nicholas, Mihalas, Stefan, Lahvis, Garet P., Lattal, K. Matthew, Mitchell, Suzanne H., David, Stephen V., Fryer, John D., Nigg, Joel T., Fair, Damien A.
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
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Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways
Wojtas, Aleksandra M., Kang, Silvia S., Olley, Benjamin M., Gatherer, Maureen, Shinohara, Mitsuru, Lozano, Patricia A., Liu, Chia-Chen, Kurti, Aishe, Baker, Kelsey E., Dickson, Dennis W., Yue, Mei, Petrucelli, Leonard, Bu, Guojun, Carare, Roxana O., Fryer, John D.
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.2017)
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Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease
Liu, Chia-Chen, Wang, Na, Chen, Yuanxin, Inoue, Yasuteru, Shue, Francis, Ren, Yingxue, Wang, Minghui, Qiao, Wenhui, Ikezu, Tadafumi C., Li, Zonghua, Zhao, Jing, Martens, Yuka, Doss, Sydney V., Rosenberg, Cassandra L., Jeevaratnam, Suren, Jia, Lin, Raulin, Ana-Caroline, Qi, Fangfang, Zhu, Yiyang, Alnobani, Alla, Knight, Joshua, Chen, Yixing, Linares, Cynthia, Kurti, Aishe, Fryer, John D., Zhang, Bin, Wu, Long-Jun, Kim, Betty Y. S., Bu, Guojun
Published in Nature immunology (01.11.2023)
Published in Nature immunology (01.11.2023)
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Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
Chew, Jeannie, Cook, Casey, Gendron, Tania F, Jansen-West, Karen, Del Rosso, Giulia, Daughrity, Lillian M, Castanedes-Casey, Monica, Kurti, Aishe, Stankowski, Jeannette N, Disney, Matthew D, Rothstein, Jeffrey D, Dickson, Dennis W, Fryer, John D, Zhang, Yong-Jie, Petrucelli, Leonard
Published in Molecular neurodegeneration (15.02.2019)
Published in Molecular neurodegeneration (15.02.2019)
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APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations
Shinohara, Mitsuru, Kanekiyo, Takahisa, Yang, Longyu, Linthicum, Duane, Shinohara, Motoko, Fu, Yuan, Price, Laura, Frisch-Daiello, Jessica L., Han, Xianlin, Fryer, John D., Bu, Guojun
Published in Annals of neurology (01.05.2016)
Published in Annals of neurology (01.05.2016)
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Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro
Cadiz, Mika P, Jensen, Tanner D, Sens, Jonathon P, Zhu, Kuixi, Song, Won-Min, Zhang, Bin, Ebbert, Mark, Chang, Rui, Fryer, John D
Published in Molecular neurodegeneration (28.03.2022)
Published in Molecular neurodegeneration (28.03.2022)
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TREM2 in CNS homeostasis and neurodegenerative disease
Painter, Meghan M, Atagi, Yuka, Liu, Chia-Chen, Rademakers, Rosa, Xu, Huaxi, Fryer, John D, Bu, Guojun
Published in Molecular neurodegeneration (04.09.2015)
Published in Molecular neurodegeneration (04.09.2015)
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APOE2 is associated with longevity independent of Alzheimer's disease
Shinohara, Mitsuru, Kanekiyo, Takahisa, Tachibana, Masaya, Kurti, Aishe, Shinohara, Motoko, Fu, Yuan, Zhao, Jing, Han, Xianlin, Sullivan, Patrick M, Rebeck, G William, Fryer, John D, Heckman, Michael G, Bu, Guojun
Published in eLife (19.10.2020)
Published in eLife (19.10.2020)
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Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation
Zheng, Honghua, Liu, Chia-Chen, Atagi, Yuka, Chen, Xiao-Fen, Jia, Lin, Yang, Longyu, He, Wencan, Zhang, Xilin, Kang, Silvia S., Rosenberry, Terrone L., Fryer, John D., Zhang, Yun-Wu, Xu, Huaxi, Bu, Guojun
Published in Neurobiology of aging (01.06.2016)
Published in Neurobiology of aging (01.06.2016)
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Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease
Shinohara, Mitsuru, Murray, Melissa E., Frank, Ryan D., Shinohara, Motoko, DeTure, Michael, Yamazaki, Yu, Tachibana, Masaya, Atagi, Yuka, Davis, Mary D., Liu, Chia-Chen, Zhao, Na, Painter, Meghan M., Petersen, Ronald C., Fryer, John D., Crook, Julia E., Dickson, Dennis W., Bu, Guojun, Kanekiyo, Takahisa
Published in Acta neuropathologica (01.08.2016)
Published in Acta neuropathologica (01.08.2016)
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