The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes
Frkic, Rebecca L., Richter, Katharina, Bruning, John B.
Published in The Journal of biological chemistry (01.09.2021)
Published in The Journal of biological chemistry (01.09.2021)
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Journal Article
Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction
Abdelkader, Elwy H., Qianzhu, Haocheng, George, Josemon, Frkic, Rebecca L., Jackson, Colin J., Nitsche, Christoph, Otting, Gottfried, Huber, Thomas
Published in Angewandte Chemie International Edition (21.03.2022)
Published in Angewandte Chemie International Edition (21.03.2022)
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Journal Article
Asymmetric Ene-Reduction of α,β-Unsaturated Compounds by F420-Dependent Oxidoreductases A Enzymes from Mycobacterium smegmatis
Kang, Suk Woo, Antoney, James, Frkic, Rebecca L., Lupton, David W., Speight, Robert, Scott, Colin, Jackson, Colin J.
Published in Biochemistry (Easton) (07.02.2023)
Published in Biochemistry (Easton) (07.02.2023)
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Journal Article
Asymmetric Ene-Reduction of α,β-Unsaturated Compounds by F 420 -Dependent Oxidoreductases A Enzymes from Mycobacterium smegmatis
Kang, Suk Woo, Antoney, James, Frkic, Rebecca L, Lupton, David W, Speight, Robert, Scott, Colin, Jackson, Colin J
Published in Biochemistry (Easton) (07.02.2023)
Published in Biochemistry (Easton) (07.02.2023)
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Conformational Preferences of the Non-Canonical Amino Acids (2S,4S)‑5-Fluoroleucine, (2S,4R)‑5-Fluoroleucine, and 5,5′-Difluoroleucine in a Protein
Frkic, Rebecca L., Tan, Yi Jiun, Abdelkader, Elwy H., Maleckis, Ansis, Tarcoveanu, Eliza, Nitsche, Christoph, Otting, Gottfried, Jackson, Colin J.
Published in Biochemistry (Easton) (14.05.2024)
Published in Biochemistry (Easton) (14.05.2024)
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Journal Article
Mononuclear binding and catalytic activity of europium(III) and gadolinium(III) at the active site of the model metalloenzyme phosphotriesterase
Breeze, Callum W., Nakano, Yuji, Campbell, Eleanor C., Frkic, Rebecca L., Lupton, David W., Jackson, Colin J.
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2024)
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2024)
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Journal Article
Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design
Saunders, Jake W., Damry, Adam M., Vongsouthi, Vanessa, Spence, Matthew A., Frkic, Rebecca L., Gomez, Chloe, Yates, Patrick A., Matthews, Dana S., Tokuriki, Nobuhiko, McLeod, Malcolm D., Jackson, Colin J.
Published in Biochemistry (Easton) (02.07.2024)
Published in Biochemistry (Easton) (02.07.2024)
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Journal Article
Through-Space Scalar 19 F- 19 F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins
Orton, Henry W, Qianzhu, Haocheng, Abdelkader, Elwy H, Habel, Edan I, Tan, Yi Jiun, Frkic, Rebecca L, Jackson, Colin J, Huber, Thomas, Otting, Gottfried
Published in Journal of the American Chemical Society (24.11.2021)
Published in Journal of the American Chemical Society (24.11.2021)
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Journal Article
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones
Elzahhar, Perihan A., Alaaeddine, Rana, Ibrahim, Tamer M., Nassra, Rasha, Ismail, Azza, Chua, Benjamin S.K., Frkic, Rebecca L., Bruning, John B., Wallner, Nadja, Knape, Tilo, von Knethen, Andreas, Labib, Hala, El-Yazbi, Ahmed F., Belal, Ahmed S.F.
Published in European journal of medicinal chemistry (01.04.2019)
Published in European journal of medicinal chemistry (01.04.2019)
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Structure–Activity Relationship of 2,4-Dichloro‑N‑(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics
Frkic, Rebecca L, He, Yuanjun, Rodriguez, Beatriz B, Chang, Mi Ra, Kuruvilla, Dana, Ciesla, Anthony, Abell, Andrew D, Kamenecka, Theodore M, Griffin, Patrick R, Bruning, John B
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Journal Article
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles
Frkic, Rebecca L., Pederick, Jordan L., Horsfall, Aimee J., Jovcevski, Blagojce, Crame, Elise E., Kowalczyk, Wioleta, Pukala, Tara L., Chang, Mi Ra, Zheng, Jie, Blayo, Anne-Laure, Abell, Andrew D., Kamenecka, Theodore M., Harbort, Joshua S., Harmer, Jeffrey R., Griffin, Patrick R, Bruning, John B.
Published in ACS chemical biology (19.05.2023)
Published in ACS chemical biology (19.05.2023)
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Journal Article
PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix
Frkic, Rebecca L., Marshall, Andrew C., Blayo, Anne-Laure, Pukala, Tara L., Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Published in iScience (27.07.2018)
Published in iScience (27.07.2018)
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Journal Article
Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways
Chang, Mi Ra, Ciesla, Anthony, Strutzenberg, Timothy S, Novick, Scott J, He, Yuanjun, Garcia-Ordonez, Ruben D, Frkic, Rebecca L, Bruning, John B, Kamenecka, Theodore M, Griffin, Patrick R
Published in ACS chemical biology (17.05.2019)
Published in ACS chemical biology (17.05.2019)
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Journal Article
Obtaining Crystals of PPARγ Ligand Binding Domain Bound to Small Molecules
Frkic, Rebecca L, Bruning, John B
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2019)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2019)
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Journal Article
Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction
Abdelkader, Elwy H., Qianzhu, Haocheng, George, Josemon, Frkic, Rebecca L., Jackson, Colin J., Nitsche, Christoph, Otting, Gottfried, Huber, Thomas
Published in Angewandte Chemie (21.03.2022)
Published in Angewandte Chemie (21.03.2022)
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Journal Article
Structural and Dynamic Elucidation of a Non-acid PPAR γ Partial Agonist: SR1988
Frkic, Rebecca L, Chua, Benjamin S, Shin, Youseung, Pascal, Bruce D, Novick, Scott J, Kamenecka, Theodore M, Griffin, Patrick R, Bruning, John B
Published in Nuclear receptor research (2018)
Published in Nuclear receptor research (2018)
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Journal Article
Pushing the limits of structure prediction with non-canonical amino acids
Habel, Edan, Qianzhu, Haocheng, Abdelkader, Elwy, Frkic, Rebecca, Jackson, Colin, Otting, Gottfried, Huber, Thomas
Published in Acta crystallographica. Section A, Foundations and advances (22.08.2023)
Published in Acta crystallographica. Section A, Foundations and advances (22.08.2023)
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Journal Article
Through-Space Scalar 19F–19F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins
Orton, Henry W, Qianzhu, Haocheng, Abdelkader, Elwy H, Habel, Edan I, Tan, Yi Jiun, Frkic, Rebecca L, Jackson, Colin J, Huber, Thomas, Otting, Gottfried
Published in Journal of the American Chemical Society (24.11.2021)
Published in Journal of the American Chemical Society (24.11.2021)
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Journal Article
Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
Johansen-Leete, Jason, Ullrich, Sven, Fry, Sarah E, Frkic, Rebecca, Bedding, Max J, Aggarwal, Anupriya, Ashhurst, Anneliese S, Ekanayake, Kasuni B, Mahawaththa, Mithun C, Sasi, Vishnu M, Luedtke, Stephanie, Ford, Daniel J, O'Donoghue, Anthony J, Passioura, Toby, Larance, Mark, Otting, Gottfried, Turville, Stuart, Jackson, Colin J, Nitsche, Christoph, Payne, Richard J
Published in Chemical science (Cambridge) (30.03.2022)
Published in Chemical science (Cambridge) (30.03.2022)
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