Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
Dubovsky, Jason A., Beckwith, Kyle A., Natarajan, Gayathri, Woyach, Jennifer A., Jaglowski, Samantha, Zhong, Yiming, Hessler, Joshua D., Liu, Ta-Ming, Chang, Betty Y., Larkin, Karilyn M., Stefanovski, Matthew R., Chappell, Danielle L., Frissora, Frank W., Smith, Lisa L., Smucker, Kelly A., Flynn, Joseph M., Jones, Jeffrey A., Andritsos, Leslie A., Maddocks, Kami, Lehman, Amy M., Furman, Richard, Sharman, Jeff, Mishra, Anjali, Caligiuri, Michael A., Satoskar, Abhay R., Buggy, Joseph J., Muthusamy, Natarajan, Johnson, Amy J., Byrd, John C.
Published in Blood (10.10.2013)
Published in Blood (10.10.2013)
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Journal Article
ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model
Chiang, Chi-Ling, Goswami, Swagata, Frissora, Frank W., Xie, Zhiliang, Yan, Pearlly S., Bundschuh, Ralf, Walker, Logan A., Huang, Xiaomeng, Mani, Rajeswaran, Mo, Xiaokui M., Baskar, Sivasubramanian, Rader, Christoph, Phelps, Mitch A., Marcucci, Guido, Byrd, John C., Lee, L. James, Muthusamy, Natarajan
Published in Blood (01.08.2019)
Published in Blood (01.08.2019)
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Journal Article
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma
Liu, Qing, Zhao, Xiaobin, Frissora, Frank, Ma, Yihui, Santhanam, Ramasamy, Jarjoura, David, Lehman, Amy, Perrotti, Danilo, Chen, Ching-Shih, Dalton, James T., Muthusamy, Natarajan, Byrd, John C.
Published in Blood (01.01.2008)
Published in Blood (01.01.2008)
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Journal Article
ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo
Mani, Rajeswaran, Chiang, Chi-Ling, Frissora, Frank W, Yan, Ribai, Mo, Xiaokui, Baskar, Sivasubramanian, Rader, Christoph, Klisovic, Rebecca, Phelps, Mitch A, Chen, Ching-Shih, Lee, Robert J, Byrd, John C, Baiocchi, Robert, Lee, L. James, Muthusamy, Natarajan
Published in Experimental hematology (01.09.2015)
Published in Experimental hematology (01.09.2015)
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Journal Article
Recombination activation gene-2-deficient blastocyst complementation analysis reveals an essential role for nuclear factor I-A transcription factor in T-cell activation
Muthusamy, Natarajan, Chen, Hui-Chen, Rajgolikar, Girish, Butz, Kenneth G, Frissora, Frank W, Gronostajski, Richard M
Published in International immunology (01.06.2011)
Published in International immunology (01.06.2011)
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Journal Article
PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia
Goswami, Swagata, Mani, Rajeswaran, Nunes, Jessica, Chiang, Chi-Ling, Zapolnik, Kevan, Hu, Eileen, Frissora, Frank, Mo, Xiaokui, Walker, Logan A., Yan, Pearlly, Bundschuh, Ralf, Beaver, Larry, Devine, Raymond, Tsai, Yo-Ting, Ventura, Ann, Xie, Zhiliang, Chen, Min, Lapalombella, Rosa, Walker, Alison, Mims, Alice, Larkin, Karilyn, Grieselhuber, Nicole, Bennett, Chad, Phelps, Mitch, Hertlein, Erin, Behbehani, Gregory, Vasu, Sumithira, Byrd, John C., Muthusamy, Natarajan
Published in Blood (03.03.2022)
Published in Blood (03.03.2022)
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Journal Article
Abstract 1541: Evaluation of ROR1 targeted antibody drug conjugate in ROR1 positive leukemia
Hu, Eileen, Do, Priscilla, Mani, Rajeswaran, Frissora, Frank, Pearson, Rebecca, Lozanski, Gerard, Peng, Haiyong, Waldmeier, Lorenz, Beerli, Roger, Rader, Christoph, Grawunder, Ulf, Byrd, John, Muthusamy, Natarajan
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Evaluation of ROR1 Targeted Antibody Drug Conjugates in Acute and Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma
Hu, Eileen, Do, Priscilla, Mani, Rajeswaran, Frissora, Frank, Peng, Haiyong, Waldmeier, Lorenz, Beerli, Roger, Rader, Christoph, Grawunder, Ulf, Byrd, John C., Muthusamy, Natarajan
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
The ETS1 Transcription Factor Is Implicated in Human and Murine Intermediate NK Cell Development Stages
Hu, Eileen, Waibl-Polania, Jessica, Frissora, Frank, Beaver, Larry State, Zapolnik, Kevan, Mundy-Bosse, Bethany L, Mishra, Anjali, Freud, Aharon G., Yu, Jianhua, Byrd, John C., Oakes, Christopher C., Ostrowski, Michael, Muthusamy, Natarajan
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Par-4 Overexpression Impedes Leukemogenesis in the Eµ-TCL1 Leukemia Model
Greene, Joseph Thomas, Ramaswamy, Rahul, McKenna, Mary K, Mani, Rajeswaran, Frissora, Frank, Wasmuth, Ronni, Tran, Minh, Mo, Xiaokui, Croce, Carlo M., Rangnekar, Vivek, Byrd, John C., Bondada, Subbarao, Muthusamy, Natarajan
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Tumor Antigen ROR1 Targeted Delivery of MiR-29b in Chronic Lymphocytic Leukemia Induces Epigenetic Reprograming Resulting in Cell Cycle Arrest
Chiang, Chi-Ling, Goswami, Swagata, Mani, Rajeswaran, Frissora, Frank, Xie, Zhiliang, Huang, Xiaomeng, Baskar, Sivasubramanian, Rader, Christoph, Phelps, Mitch A., Marcucci, Guido, Byrd, John C., Lee, James L., Muthusamy, Natarajan
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Role of Prostate apoptosis response-4 tumor suppressor in the survival and growth of Chronic Lymphocytic Leukemia
McKenna, Mary Kathryn, Nooti, Sunil K, Alhakeem, Sara Samir, Gachuki, Beth W, Frissora, Frank, Greene, Joseph T, Byrd, John C, Muthusamy, Natarajan, Rangnekar, Vivek R, Bondada, Subbarao
Published in The Journal of immunology (1950) (01.05.2016)
Published in The Journal of immunology (1950) (01.05.2016)
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Journal Article
Role of Prostate Apoptosis Response-4 Tumor Suppressor in the Survival and Growth of Chronic Lymphocytic Leukemia
Nooti, Sunil K, McKenna, Mary K, Frissora, Frank W, Gachuki, Beth W, Alhakeem, Sara S, Greene, Joseph T, Muthusamy, Natarajan, Rangnekar, Vivek M, Bondada, Subbarao
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia
Hu, Eileen Y., Do, Priscilla, Goswami, Swagata, Nunes, Jessica, Chiang, Chi-ling, Elgamal, Sara, Ventura, Ann M., Cheney, Carolyn, Zapolnik, Kevan, Williams, Erich, Mani, Rajeswaran, Frissora, Frank, Mo, Xiaokui, Waldmeier, Lorenz, Beerli, Roger R., Peng, Haiyong, Rader, Christoph, Long, Meixiao, Grawunder, Ulf, Byrd, John C., Muthusamy, Natarajan
Published in Blood advances (24.08.2021)
Published in Blood advances (24.08.2021)
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Journal Article
Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia
Mani, R, Mao, Y, Frissora, F W, Chiang, C-L, Wang, J, Zhao, Y, Wu, Y, Yu, B, Yan, R, Mo, X, Yu, L, Flynn, J, Jones, J, Andritsos, L, Baskar, S, Rader, C, Phelps, M A, Chen, C-S, Lee, R J, Byrd, J C, Lee, L J, Muthusamy, N
Published in Leukemia (01.02.2015)
Published in Leukemia (01.02.2015)
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Journal Article
PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model
Motiwala, T, Kutay, H, Zanesi, N, Frissora, F W, Mo, X, Muthusamy, N, Jacob, S T
Published in Leukemia (01.06.2015)
Published in Leukemia (01.06.2015)
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Journal Article
Immunoliposomal Delivery of Mir-29b By Targeting Tumor Antigen ROR1 Induces Epigenetic Reprograming in Human-ROR1-Expressed Mouse Model of Chronic Lymphocytic Leukemia
Chiang, Chi-Ling, Frissora, Frank W, Xie, Zhiliang, Huang, Xiaomeng, Mani, Rajeswaran, Baskar, Sivasubramanian, Rader, Christoph, Chan, Kenneth K., Marcucci, Guido, Byrd, John C., Lee, L. James, Muthusamy, Natarajan
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
CD33 Targeted Immunoliposomal Delivery of OSU-2S, a Non-Immunosuppressive FTY720 Derivative, Mediates Selective Cytotoxicity in Acute Myeloid Leukemia
Goswami, Swagata, Mani, Rajeswaran, Chiang, Chi-Ling, Frissora, Frank W, Mo, Xiaokui, Xie, Zhiliang, Bucci, Donna, Gordon, Amber, Lucas, David M., Blum, William, Walker, Alison R., Mims, Alice S., Klisovic, Rebecca B, Chen, Ching-Shih, Lee, Robert J, Byrd, John C., Phelps, Mitch A., Vasu, Sumithira, Muthusamy, Natarajan
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Abstract 4406: ROR1 targeted delivery of OSU-2S, a non-immunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle cell lymphoma in-vitro and in-vivo
Mani, Rajeswaran, Chiang, Chi-Ling, Frissora, Frank W., Yan, Ribai, Mo, Xiaokui, Baskar, Sivasubramanian, Rader, Christoph, Phelps, Mitch, Chen, Ching-Shih, Lee, Robert, Byrd, John, Baiocchi, Robert, Lee, L James, Muthusamy, Natarajan
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
The CD37-targeted antibody–drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model
Beckwith, K A, Frissora, F W, Stefanovski, M R, Towns, W H, Cheney, C, Mo, X, Deckert, J, Croce, C M, Flynn, J M, Andritsos, L A, Jones, J A, Maddocks, K J, Lozanski, G, Byrd, J C, Muthusamy, N
Published in Leukemia (01.07.2014)
Published in Leukemia (01.07.2014)
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