Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens
Barbachyn, Michael R, Cleek, Gary J, Dolak, Lester A, Garmon, Stuart A, Morris, Joel, Seest, Eric P, Thomas, Richard C, Toops, Dana S, Watt, William, Wishka, Donn G, Ford, Charles W, Zurenko, Gary E, Hamel, Judith C, Schaadt, Ronda D, Stapert, Douglas, Yagi, Betty H, Adams, Wade J, Friis, Janice M, Slatter, J. Gregory, Sams, James P, Oien, Nancee L, Zaya, Matthew J, Wienkers, Larry C, Wynalda, Michael A
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
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Predicting oral absorption of drugs: A case study with a novel class of antimicrobial agents
HILGERS, Allen R, SMITH, Donald P, SHONE, Eric M, BURTON, Philip S, BIERMACHER, John J, DAY, Jeffrey S, JENSEN, Jana L, SIMS, Sandra M, ADAMS, Wade J, FRIIS, Janice M, PALANDRA, Joe, HOSLEY, John D
Published in Pharmaceutical research (01.08.2003)
Published in Pharmaceutical research (01.08.2003)
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New Antibacterial tetrahydro-4(2 H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones
Singh, Upinder, Raju, B, Lam, Stuart, Zhou, Joseph, Gadwood, Robert C, Ford, Charles W, Zurenko, Gary E, Schaadt, Ronda D, Morin, Sara E, Adams, Wade J, Friis, Janice M, Courtney, Maria, Palandra, Joe, Hackbarth, Corinne J, Lopez, Sara, Wu, Charlotte, Mortell, Kathleen H, Trias, Joaquim, Yuan, Zhengyu, Patel, Dinesh V, Gordeev, Mikhail F
Published in Bioorganic & medicinal chemistry letters (01.12.2003)
Published in Bioorganic & medicinal chemistry letters (01.12.2003)
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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones
Ciske, Fred L, Barbachyn, Michael R, Genin, Michael J, Grega, Kevin C, Lee, Chi Sing, Dolak, Lester A, Seest, Eric P, Watt, William, Adams, Wade J, Friis, Janice M, Ford, Charles W, Zurenko, Gary E
Published in Bioorganic & medicinal chemistry letters (01.12.2003)
Published in Bioorganic & medicinal chemistry letters (01.12.2003)
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(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor
Wishka, DG, Graber, DR, Kopta, LA, Olmsted, RA, Friis, JM, Hosley, JD, Adams, WJ, Seest, EP, Castle, TM, Dolak, LA, Keiser, BJ, Yagi, Y, Jeganathan, A, Schlachter, ST, Murphy, MJ, Cleek, GJ, Nugent, RA, Poppe, SM, Swaney, SM, Han, FS, Watt, W, White, WL, Poel, TJ, Thomas, RC, Voorman, RL, Stefanski, KJ, Stehle, RG, Tarpley, WG, Morris, J
Published in Journal of medicinal chemistry (23.04.1998)
Published in Journal of medicinal chemistry (23.04.1998)
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Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors
Romero, Donna L, Olmsted, Robert A, Poel, Toni Jo, Morge, Raymond A, Biles, Carolyn, Keiser, Barbara J, Kopta, Laurice A, Friis, Jan M, Hosley, John D, Stefanski, Kevin J, Wishka, Donn G, Evans, David B, Morris, Joel, Stehle, Randy G, Sharma, Satish K, Yagi, Yoshihiko, Voorman, Richard L, Adams, Wade J, Tarpley, W. Gary, Thomas, Richard C
Published in Journal of medicinal chemistry (13.09.1996)
Published in Journal of medicinal chemistry (13.09.1996)
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Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Potent Antibacterial Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis
Genin, Michael J, Hutchinson, Douglas K, Allwine, Debra A, Hester, Jackson B, Emmert, D. Edward, Garmon, Stuart A, Ford, Charles W, Zurenko, Gary E, Hamel, Judith C, Schaadt, Ronda D, Stapert, Douglas, Yagi, Betty H, Friis, Janice M, Shobe, Eric M, Adams, Wade J
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors: Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs
Genin, Michael J., Poel, Toni J., Yagi, Yoshihiko, Biles, Carolyn, Althaus, Irene, Keiser, Barbara J., Kopta, Laurice A., Friis, Jan M., Reusser, Fritz, Adams, Wade J., Voorman, Richard L., Thomas, Richard C., Romero, Donna L.
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
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Synthesis and Structure−Activity Relationships of the (Alkylamino)piperidine-Containing BHAP Class of Non-Nucleoside Reverse Transcriptase Inhibitors: Effect of 3-Alkylpyridine Ring Substitution
Genin, Michael J, Poel, Toni J, May, Paul D, Kopta, Laurice A, Yagi, Yoshihiko, Olmsted, Robert A, Friis, Janice M, Voorman, Richard L, Adams, Wade J, Thomas, Richard C, Romero, Donna L
Published in Journal of medicinal chemistry (07.10.1999)
Published in Journal of medicinal chemistry (07.10.1999)
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Development of activity assays for high-volume evaluation of human immunodeficiency virus (HIV) protease inhibitors in rat serum: results with ditekiren
Wilkinson, K F, Rush, B D, Sharma, S K, Evans, D B, Ruwart, M J, Friis, J M, Bohanon, M J, Tomich, P K
Published in Pharmaceutical research (01.04.1993)
Published in Pharmaceutical research (01.04.1993)
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Development of a sensitive activity assay for high-volume evaluation of human renin inhibitory peptides in rat serum: results with U-71,038
Ruwart, M J, Sharma, S K, Harris, D W, Lakings, D B, Rush, B D, Wilkinson, K F, Cornette, J C, Evans, D B, Friis, J M, Cook, K J
Published in Pharmaceutical research (01.04.1990)
Published in Pharmaceutical research (01.04.1990)
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Pharmacokinetics of furegrelate after oral administration to normal humans
Lakings, D B, Friis, J M, Lunan, C M, VanderLugt, J T, Mohrland, J S
Published in Pharmaceutical research (01.01.1989)
Published in Pharmaceutical research (01.01.1989)
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Simple, rapid and sensitive high-performance liquid chromatographic determination of delavirdine and its N-desisopropyl metabolite in human plasma
Staton, B.A., Johnson, M.G., Friis, J.M., Adams, W.J.
Published in Journal of chromatography. B, Biomedical applications (09.06.1995)
Published in Journal of chromatography. B, Biomedical applications (09.06.1995)
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