Translational pharmacokinetic‐pharmacodynamic modeling of preclinical and clinical data of the oral MET inhibitor tepotinib to determine the recommended phase II dose
Xiong, Wenyuan, Friese‐Hamim, Manja, Johne, Andreas, Stroh, Christopher, Klevesath, Manfred, Falchook, Gerald S., Hong, David S., Girard, Pascal, El Bawab, Samer
Published in CPT: pharmacometrics and systems pharmacology (01.05.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.05.2021)
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Journal Article
EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
BLADT, Friedhelm, FADEN, Bettina, PEHL, Ulrich, STIEBER, Frank, SCHADT, Oliver, BLAUKAT, Andree, FRIESE-HAMIM, Manja, KNUEHL, Christine, WILM, Claudia, FITTSCHEN, Claus, GRÄDLER, Ulrich, MEYRING, Michael, DORSCH, Dieter, JAEHRLING, Frank
Published in Clinical cancer research (01.06.2013)
Published in Clinical cancer research (01.06.2013)
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Journal Article
Association of EGFR Expression Level and Cetuximab Activity in Patient-Derived Xenograft Models of Human Non-Small Cell Lung Cancer
AMENDT, Christiane, STAUB, Eike, FRIESE-HAMIM, Manja, STÖRKEL, Stephan, STROH, Christopher
Published in Clinical cancer research (01.09.2014)
Published in Clinical cancer research (01.09.2014)
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Journal Article
메티오닌 아미노펩티다아제 2 억제제 및 VEGFR/VEGF 억제제의 조합
BOGATYROVA OLGA, GIMMI CLAUDE, ROHDICH FELIX, SCHULTES CHRISTOPH, FRIESE HAMIM MANJA
Year of Publication 17.03.2023
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Year of Publication 17.03.2023
Patent
Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2
Lignet, Floriane, Friese-Hamim, Manja, Jaehrling, Frank, El Bawab, Samer, Rohdich, Felix
Published in Pharmaceutical research (01.12.2023)
Published in Pharmaceutical research (01.12.2023)
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Journal Article
The Preclinical Pharmacology of Tepotinib-A Highly Selective MET Inhibitor with Activity in Tumors Harboring MET Alterations
Albers, Joachim, Friese-Hamim, Manja, Clark, Anderson, Schadt, Oliver, Walter-Bausch, Gina, Stroh, Christopher, Johne, Andreas, Karachaliou, Niki, Blaukat, Andree
Published in Molecular cancer therapeutics (05.07.2023)
Published in Molecular cancer therapeutics (05.07.2023)
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Journal Article
METAP-2 PYRROLIDINONE DERIVATIVES AS METAP-2 INHIBITORS
ZENKE FRANK, HAHN DIANE, ROHDICH FELIX, HEINRICH TIMO, FRIESE HAMIM MANJA
Year of Publication 22.03.2017
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Year of Publication 22.03.2017
Patent
First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors
Falchook, Gerald S, Kurzrock, Razelle, Amin, Hesham M, Xiong, Wenyuan, Fu, Siqing, Piha-Paul, Sarina A, Janku, Filip, Eskandari, Ghazaleh, Catenacci, Daniel V, Klevesath, Manfred, Bruns, Rolf, Stammberger, Uz, Johne, Andreas, Bladt, Friedhelm, Friese-Hamim, Manja, Girard, Pascal, El Bawab, Samer, Hong, David S
Published in Clinical cancer research (15.03.2020)
Published in Clinical cancer research (15.03.2020)
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Journal Article
Abstract 4663: Combination of c-Met inhibitor tepotinib (MSC2156119J) and a third-generation EGFR inhibitor can overcome double resistance mediated by EGFR T790M mutation and c-Met amplification in non-small cell lung cancer models
Friese-Hamim, Manja, Locatelli, Giuseppe, Bladt, Friedhelm
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract P5-08-04: LMP7-specific inhibitor M3258 modulates the tumor microenvironment of aggressive breast cancer
Xie, Xuemei, Lee, Jangsoon, Manyam, Ganiraju C, Pearson, Troy, Walter-Bausch, Gina, Friese-Hamim, Manja, Goodstal, Samantha M, Tripathy, Debu, Jing, Wang, Sanderson, Michael, Ueno, Naoto T
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Journal Article
Translational PK/PD Modeling of Tumor Growth Inhibition and Target Inhibition to Support Dose Range Selection of the LMP7 Inhibitor M3258 in Relapsed/Refractory Multiple Myeloma
Lignet, Floriane, Esdar, Christina, Walter-Bausch, Gina, Friese-Hamim, Manja, Stinchi, Sofia, Drouin, Elise, El Bawab, Samer, Becker, Andreas D, Gimmi, Claude, Sanderson, Michael P, Rohdich, Felix
Published in The Journal of pharmacology and experimental therapeutics (01.01.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2023)
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Journal Article
CYCLIC AMIDES AS METAP-2 INHIBITORS
ZENKE FRANK, KRIER MIREILLE, HEINRICH TIMO, SEENISAMY JEYAPRAKASHNARAYANAN, FRIESE HAMIM MANJA
Year of Publication 13.01.2015
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Year of Publication 13.01.2015
Patent