Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
Agliardi, Giulia, Liuzzi, Anna Rita, Hotblack, Alastair, De Feo, Donatella, Núñez, Nicolás, Stowe, Cassandra L., Friebel, Ekaterina, Nannini, Francesco, Rindlisbacher, Lukas, Roberts, Thomas A., Ramasawmy, Rajiv, Williams, Iwan P., Siow, Bernard M., Lythgoe, Mark F., Kalber, Tammy L., Quezada, Sergio A., Pule, Martin A., Tugues, Sonia, Straathof, Karin, Becher, Burkhard
Published in Nature communications (19.01.2021)
Published in Nature communications (19.01.2021)
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Journal Article
Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes
Friebel, Ekaterina, Kapolou, Konstantina, Unger, Susanne, Núñez, Nicolás Gonzalo, Utz, Sebastian, Rushing, Elisabeth Jane, Regli, Luca, Weller, Michael, Greter, Melanie, Tugues, Sonia, Neidert, Marian Christoph, Becher, Burkhard
Published in Cell (25.06.2020)
Published in Cell (25.06.2020)
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Journal Article
IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation
Amorim, Ana, De Feo, Donatella, Friebel, Ekaterina, Ingelfinger, Florian, Anderfuhren, Cyrill Dimitri, Krishnarajah, Sinduya, Andreadou, Myrto, Welsh, Christina A., Liu, Zhaoyuan, Ginhoux, Florent, Greter, Melanie, Becher, Burkhard
Published in Nature immunology (01.02.2022)
Published in Nature immunology (01.02.2022)
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Journal Article
CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis
Tacconi, Carlotta, Commerford, Catharina D., Dieterich, Lothar C., Schwager, Simon, He, Yuliang, Ikenberg, Kristian, Friebel, Ekaterina, Becher, Burkhard, Tugues, Sònia, Detmar, Michael
Published in Cell reports (Cambridge) (13.04.2021)
Published in Cell reports (Cambridge) (13.04.2021)
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Journal Article
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β
Komuczki, Juliana, Tuzlak, Selma, Friebel, Ekaterina, Hartwig, Tom, Spath, Sabine, Rosenstiel, Philip, Waisman, Ari, Opitz, Lennart, Oukka, Mohammed, Schreiner, Bettina, Pelczar, Pawel, Becher, Burkhard
Published in Immunity (Cambridge, Mass.) (21.05.2019)
Published in Immunity (Cambridge, Mass.) (21.05.2019)
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Journal Article
Innate lymphoid cells as regulators of the tumor microenvironment
Tugues, Sonia, Ducimetiere, Laura, Friebel, Ekaterina, Becher, Burkhard
Published in Seminars in immunology (01.02.2019)
Published in Seminars in immunology (01.02.2019)
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Journal Article
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Pfister, Dominik, Núñez, Nicolás Gonzalo, Govaere, Olivier, Pinter, Matthias, Szydlowska, Marta, Qiu, Mengjie, Deczkowska, Aleksandra, Weiner, Assaf, Müller, Florian, Sinha, Ankit, Friebel, Ekaterina, Engleitner, Thomas, Lenggenhager, Daniela, Moncsek, Anja, Heide, Danijela, Stirm, Kristin, Kosla, Jan, Kotsiliti, Eleni, Leone, Valentina, Dudek, Michael, Yousuf, Suhail, Inverso, Donato, Singh, Indrabahadur, Teijeiro, Ana, Castet, Florian, Montironi, Carla, Haber, Philipp K., Tiniakos, Dina, Bedossa, Pierre, Cockell, Simon, Younes, Ramy, Marra, Fabio, Schattenberg, Jörn M., Allison, Michael, Bugianesi, Elisabetta, Ratziu, Vlad, D’Alessio, Antonio, Personeni, Nicola, Rimassa, Lorenza, Daly, Ann K., Scheiner, Bernhard, Pomej, Katharina, Kirstein, Martha M., Peck-Radosavljevic, Markus, Hucke, Florian, Finkelmeier, Fabian, Trojan, Jörg, Schulze, Kornelius, Wege, Henning, Koch, Sandra, Weinmann, Arndt, Bueter, Marco, Rössler, Fabian, Siebenhüner, Alexander, Mallm, Jan-Philipp, Umansky, Viktor, Jugold, Manfred, Luedde, Tom, Schietinger, Andrea, Schirmacher, Peter, Emu, Brinda, Augustin, Hellmut G., Billeter, Adrian, Müller-Stich, Beat, Kikuchi, Hiroto, Duda, Dan G., Waldschmidt, Dirk-Thomas, Rahbari, Nuh, Mei, Henrik E., Schulz, Axel Ronald, Ringelhan, Marc, Malek, Nisar, Spahn, Stephan, Bitzer, Michael, Ruiz de Galarreta, Marina, Lujambio, Amaia, Dufour, Jean-Francois, Marron, Thomas U., Kaseb, Ahmed, Kudo, Masatoshi, Huang, Yi-Hsiang, Djouder, Nabil, Wolter, Katharina, Zender, Lars, Decaens, Thomas, Pinato, David J., Rad, Roland, Mertens, Joachim C., Weber, Achim, Unger, Kristian, Meissner, Felix, Roth, Susanne, Jilkova, Zuzana Macek, Claassen, Manfred, Anstee, Quentin M., Amit, Ido, Knolle, Percy, Becher, Burkhard, Llovet, Josep M., Heikenwalder, Mathias
Published in Nature (London) (15.04.2021)
Published in Nature (London) (15.04.2021)
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Journal Article
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Kreutmair, Stefanie, Unger, Susanne, Núñez, Nicolás Gonzalo, Ingelfinger, Florian, Alberti, Chiara, De Feo, Donatella, Krishnarajah, Sinduya, Kauffmann, Manuel, Friebel, Ekaterina, Babaei, Sepideh, Gaborit, Benjamin, Lutz, Mirjam, Jurado, Nicole Puertas, Malek, Nisar P., Goepel, Siri, Rosenberger, Peter, Häberle, Helene A., Ayoub, Ikram, Al-Hajj, Sally, Nilsson, Jakob, Claassen, Manfred, Liblau, Roland, Martin-Blondel, Guillaume, Bitzer, Michael, Roquilly, Antoine, Becher, Burkhard
Published in Immunity (Cambridge, Mass.) (13.07.2021)
Published in Immunity (Cambridge, Mass.) (13.07.2021)
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Journal Article
Twin study reveals non-heritable immune perturbations in multiple sclerosis
Ingelfinger, Florian, Gerdes, Lisa Ann, Kavaka, Vladyslav, Krishnarajah, Sinduya, Friebel, Ekaterina, Galli, Edoardo, Zwicky, Pascale, Furrer, Reinhard, Peukert, Christian, Dutertre, Charles-Antoine, Eglseer, Klara Magdalena, Ginhoux, Florent, Flierl-Hecht, Andrea, Kümpfel, Tania, De Feo, Donatella, Schreiner, Bettina, Mundt, Sarah, Kerschensteiner, Martin, Hohlfeld, Reinhard, Beltrán, Eduardo, Becher, Burkhard
Published in Nature (London) (03.03.2022)
Published in Nature (London) (03.03.2022)
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Journal Article
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology
Gullotta, Giorgia Serena, De Feo, Donatella, Friebel, Ekaterina, Semerano, Aurora, Scotti, Giulia Maria, Bergamaschi, Andrea, Butti, Erica, Brambilla, Elena, Genchi, Angela, Capotondo, Alessia, Gallizioli, Mattia, Coviello, Simona, Piccoli, Marco, Vigo, Tiziana, Della Valle, Patrizia, Ronchi, Paola, Comi, Giancarlo, D’Angelo, Armando, Maugeri, Norma, Roveri, Luisa, Uccelli, Antonio, Becher, Burkhard, Martino, Gianvito, Bacigaluppi, Marco
Published in Nature immunology (01.06.2023)
Published in Nature immunology (01.06.2023)
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Journal Article
Meeting report of the 20th International Congress of Neuropathology (ICN) 2023 in Berlin
Goebel, Hans H., Koch, Arend, Radbruch, Helena, Schmid, Simone, Friebel, Ekaterina, Stenzel, Werner, Heppner, Frank L., Capper, David
Published in Brain pathology (Zurich, Switzerland) (01.03.2024)
Published in Brain pathology (Zurich, Switzerland) (01.03.2024)
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Journal Article
Conference Proceeding
IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice
Andreadou, Myrto, Ingelfinger, Florian, De Feo, Donatella, Cramer, Teresa L. M., Tuzlak, Selma, Friebel, Ekaterina, Schreiner, Bettina, Eede, Pascale, Schneeberger, Shirin, Geesdorf, Maria, Ridder, Frederike, Welsh, Christina A., Power, Laura, Kirschenbaum, Daniel, Tyagarajan, Shiva K., Greter, Melanie, Heppner, Frank L., Mundt, Sarah, Becher, Burkhard
Published in Nature neuroscience (01.10.2023)
Published in Nature neuroscience (01.10.2023)
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Journal Article
Preexisting comorbidities shape the immune response associated with severe COVID-19
Kreutmair, Stefanie, Kauffmann, Manuel, Unger, Susanne, Ingelfinger, Florian, Núñez, Nicolás Gonzalo, Alberti, Chiara, De Feo, Donatella, Krishnarajah, Sinduya, Friebel, Ekaterina, Ulutekin, Can, Babaei, Sepideh, Gaborit, Benjamin, Lutz, Mirjam, Jurado, Nicole Puertas, Malek, Nisar P., Göpel, Siri, Rosenberger, Peter, Häberle, Helene A., Ayoub, Ikram, Al-Hajj, Sally, Claassen, Manfred, Liblau, Roland, Martin-Blondel, Guillaume, Bitzer, Michael, Roquilly, Antoine, Becher, Burkhard
Published in Journal of allergy and clinical immunology (01.08.2022)
Published in Journal of allergy and clinical immunology (01.08.2022)
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Journal Article
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19
Radke, Josefine, Meinhardt, Jenny, Aschman, Tom, Chua, Robert Lorenz, Farztdinov, Vadim, Lukassen, Sören, Ten, Foo Wei, Friebel, Ekaterina, Ishaque, Naveed, Franz, Jonas, Huhle, Valerie Helena, Mothes, Ronja, Peters, Kristin, Thomas, Carolina, Schneeberger, Shirin, Schumann, Elisa, Kawelke, Leona, Jünger, Julia, Horst, Viktor, Streit, Simon, von Manitius, Regina, Körtvélyessy, Péter, Vielhaber, Stefan, Reinhold, Dirk, Hauser, Anja E., Osterloh, Anja, Enghard, Philipp, Ihlow, Jana, Elezkurtaj, Sefer, Horst, David, Kurth, Florian, Müller, Marcel A., Gassen, Nils C., Melchert, Julia, Jechow, Katharina, Timmermann, Bernd, Fernandez-Zapata, Camila, Böttcher, Chotima, Stenzel, Werner, Krüger, Elke, Landthaler, Markus, Wyler, Emanuel, Corman, Victor, Stadelmann, Christine, Ralser, Markus, Eils, Roland, Heppner, Frank L., Mülleder, Michael, Conrad, Christian, Radbruch, Helena
Published in Nature neuroscience (01.03.2024)
Published in Nature neuroscience (01.03.2024)
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Journal Article
Single cell mapping of human brain tumors reveals tumor-specific education of tissue-invading leukocytes
Friebel, Ekaterina, Kapolou, Konstantina, Unger, Susanne, Nunez, Nicolas, Utz, Sebastian, Rushing, Elisabeth Jane, Regli, Luca, Weller, Michael, Greter, Melanie, Tugues, Sonia, Neidert, Marian Christoph, Becher, Burkhard
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Kreutmair, Stefanie, Unger, Susanne, Núñez, Nicolás Gonzalo, Ingelfinger, Florian, Alberti, Chiara, De Feo, Donatella, Krishnarajah, Sinduya, Kauffmann, Manuel, Friebel, Ekaterina, Babaei, Sepideh, Gaborit, Benjamin, Lutz, Mirjam, Jurado, Nicole Puertas, Malek, Nisar P, Goepel, Siri, Rosenberger, Peter, Häberle, Helene A, Ayoub, Ikram, Al-Hajj, Sally, Nilsson, Jakob, Claassen, Manfred, Liblau, Roland, Martin-Blondel, Guillaume, Bitzer, Michael, Roquilly, Antoine, Becher, Burkhard
Published in Immunity (Cambridge, Mass.) (08.02.2022)
Published in Immunity (Cambridge, Mass.) (08.02.2022)
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Journal Article
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia: correction
Kreutmair, Stefanie, Unger, Susanne, Núñez, Nicolás Gonzalo, Ingelfinger, Florian, Alberti, Chiara, de Feo, Donatella, Krishnarajah, Sinduya, Kauffmann, Manuel, Friebel, Ekaterina, Babaei, Sepideh, Gaborit, Benjamin, Lutz, Mirjam, Jurado, Nicole Puertas, Malek, Nisar, Goepel, Siri, Rosenberger, Peter, Häberle, Helene, Ayoub, Ikram, Al-Hajj, Sally, Nilsson, Jakob, Claassen, Manfred, Liblau, Roland, Martin-Blondel, Guillaume, Bitzer, Michael, Roquilly, Antoine, Becher, Burkhard
Published in Immunity (Cambridge, Mass.) (01.02.2022)
Published in Immunity (Cambridge, Mass.) (01.02.2022)
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Journal Article
Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors
Nuñez, Nicolas Gonzalo, Berner, Fiamma, Friebel, Ekaterina, Unger, Susanne, Wyss, Nina, Gomez, Julia Martinez, Purde, Mette-Triin, Niederer, Rebekka, Porsch, Maximilian, Lichtensteiger, Christa, Kramer, Rafaela, Erdmann, Michael, Schmitt, Christina, Heinzerling, Lucie, Abdou, Marie-Therese, Karbach, Julia, Schadendorf, Dirk, Zimmer, Lisa, Ugurel, Selma, Klümper, Niklas, Hölzel, Michael, Power, Laura, Kreutmair, Stefanie, Capone, Mariaelena, Madonna, Gabriele, Cevhertas, Lacin, Heider, Anja, Amaral, Teresa, Hasan Ali, Omar, Bomze, David, Dimitriou, Florentia, Diem, Stefan, Ascierto, Paolo Antonio, Dummer, Reinhard, Jäger, Elke, Driessen, Christoph, Levesque, Mitchell Paul, van de Veen, Willem, Joerger, Markus, Früh, Martin, Becher, Burkhard, Flatz, Lukas
Published in Med (New York, N.Y. : Online) (10.02.2023)
Published in Med (New York, N.Y. : Online) (10.02.2023)
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Journal Article