Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors
Ehmke, Veronika, Quinsaat, Jose Enrico Q., Rivera-Fuentes, Pablo, Heindl, Cornelia, Freymond, Celine, Rottmann, Matthias, Brun, Reto, Schirmeister, Tanja, Diederich, Francois
Published in Organic & biomolecular chemistry (14.08.2012)
Published in Organic & biomolecular chemistry (14.08.2012)
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Heterochromatin Protein 1 Secures Survival and Transmission of Malaria Parasites
Brancucci, Nicolas M.B., Bertschi, Nicole L., Zhu, Lei, Niederwieser, Igor, Chin, Wai Hoe, Wampfler, Rahel, Freymond, Céline, Rottmann, Matthias, Felger, Ingrid, Bozdech, Zbynek, Voss, Till S.
Published in Cell host & microbe (13.08.2014)
Published in Cell host & microbe (13.08.2014)
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Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities
Witschel, Matthias C, Rottmann, Matthias, Schwab, Anatol, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Seet, Michael, Tonazzi, Sandro, Schwertz, Geoffrey, Stelzer, Frank, Mietzner, Thomas, McNamara, Case, Thater, Frank, Freymond, Céline, Jaruwat, Aritsara, Pinthong, Chatchadaporn, Riangrungroj, Pinpunya, Oufir, Mouhssin, Hamburger, Matthias, Mäser, Pascal, Sanz-Alonso, Laura M, Charman, Susan, Wittlin, Sergio, Yuthavong, Yongyuth, Chaiyen, Pimchai, Diederich, François
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
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Deorphaning Pyrrolopyrazines as Potent Multi-Target Antimalarial Agents
Reker, Daniel, Seet, Michael, Pillong, Max, Koch, Christian P., Schneider, Petra, Witschel, Matthias C., Rottmann, Matthias, Freymond, Céline, Brun, Reto, Schweizer, Bernd, Illarionov, Boris, Bacher, Adelbert, Fischer, Markus, Diederich, François, Schneider, Gisbert
Published in Angewandte Chemie (International ed.) (01.07.2014)
Published in Angewandte Chemie (International ed.) (01.07.2014)
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Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model
Lakshminarayana, Suresh B, Freymond, Céline, Fischli, Christoph, Yu, Jing, Weber, Sebastian, Goh, Anne, Yeung, Bryan K S, Ho, Paul C, Dartois, Véronique, Diagana, Thierry T, Rottmann, Matthias, Blasco, Francesca
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
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Characterization of a Serine Hydrolase Targeted by Acyl-protein Thioesterase Inhibitors in Toxoplasma gondii
Kemp, Louise E., Rusch, Marion, Adibekian, Alexander, Bullen, Hayley E., Graindorge, Arnault, Freymond, Céline, Rottmann, Matthias, Braun-Breton, Catherine, Baumeister, Stefan, Porfetye, Arthur T., Vetter, Ingrid R., Hedberg, Christian, Soldati-Favre, Dominique
Published in The Journal of biological chemistry (20.09.2013)
Published in The Journal of biological chemistry (20.09.2013)
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Potent Inhibitors of Malarial Aspartic Proteases, the Plasmepsins, by Hydroformylation of Substituted 7-Azanorbornenes
Aureggi, Valentina, Ehmke, Veronika, Wieland, Joerg, Schweizer, W. Bernd, Bernet, Bruno, Bur, Daniel, Meyer, Solange, Rottmann, Matthias, Freymond, Céline, Brun, Reto, Breit, Bernhard, Diederich, François
Published in Chemistry : a European journal (02.01.2013)
Published in Chemistry : a European journal (02.01.2013)
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Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei
Ehmke, Veronika, Heindl, Cornelia, Rottmann, Matthias, Freymond, Céline, Schweizer, W. Bernd, Brun, Reto, Stich, August, Schirmeister, Tanja, Diederich, François
Published in ChemMedChem (07.02.2011)
Published in ChemMedChem (07.02.2011)
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Identification of 1,3-Diiminoisoindoline Carbohydrazides as Potential Antimalarial Candidates
Mombelli, Paolo, Witschel, Matthias C., van Zijl, Anthoni W., Geist, Julie G., Rottmann, Matthias, Freymond, Céline, Röhl, Franz, Kaiser, Marcel, Illarionova, Victoria, Fischer, Markus, Siepe, Isabella, Schweizer, W. Bernd, Brun, Reto, Diederich, François
Published in ChemMedChem (02.01.2012)
Published in ChemMedChem (02.01.2012)
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Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-ray Crystal Structure Analysis with Human CathepsinL
Ehmke, Veronika, Winkler, Edwin, Banner, David W, Haap, Wolfgang, Schweizer, W Bernd, Rottmann, Matthias, Kaiser, Marcel, Freymond, Céline, Schirmeister, Tanja, Diederich, François
Published in ChemMedChem (01.06.2013)
Published in ChemMedChem (01.06.2013)
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Journal Article
Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitorsDedicated to Professor Wilfred van Gunsteren on the occasion of his 65th birthday.This article is part of the Organic & Biomolecular Chemistry 10th Anniversary issue.Electronic supplementary information (ESI) available: Detailed experimental procedures and spectroscopic data for all compounds, biological assays and additional figures and tables. See DOI: 10.1039/c2ob00034b
Ehmke, Veronika, Quinsaat, Jose Enrico Q, Rivera-Fuentes, Pablo, Heindl, Cornelia, Freymond, Céline, Rottmann, Matthias, Brun, Reto, Schirmeister, Tanja, Diederich, François
Year of Publication 14.08.2012
Year of Publication 14.08.2012
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Journal Article
Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-ray Crystal Structure Analysis with Human Cathepsin L
Ehmke, Veronika, Winkler, Edwin, Banner, David W., Haap, Wolfgang, Schweizer, W. Bernd, Rottmann, Matthias, Kaiser, Marcel, Freymond, Céline, Schirmeister, Tanja, Diederich, François
Published in ChemMedChem (01.06.2013)
Published in ChemMedChem (01.06.2013)
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Journal Article
Identifizierung von Pyrrolopyrazinen als polypotente Liganden mit Antimalariawirkung
Reker, Daniel, Seet, Michael, Pillong, Max, Koch, Christian P., Schneider, Petra, Witschel, Matthias C., Rottmann, Matthias, Freymond, Céline, Brun, Reto, Schweizer, Bernd, Illarionov, Boris, Bacher, Adelbert, Fischer, Markus, Diederich, François, Schneider, Gisbert
Published in Angewandte Chemie (01.07.2014)
Published in Angewandte Chemie (01.07.2014)
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Journal Article
Optimization of Triazine Nitriles as Rhodesain Inhibitors: StructureActivity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-ray Crystal Structure Analysis with Human CathepsinL
Ehmke, Veronika, Winkler, Edwin, Banner, David W., Haap, Wolfgang, Schweizer, Bernd, Rottmann, Matthias, Kaiser, Marcel, Freymond, Celine, Schirmeister, Tanja, Diederich, Francois
Published in ChemMedChem (01.06.2013)
Published in ChemMedChem (01.06.2013)
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Journal Article
Identifizierung von Pyrrolopyrazinen als polypotente Liganden mit Antimalariawirkung
Reker, Daniel, Seet, Michael, Pillong, Max, Koch, Christian P., Schneider, Petra, Witschel, Matthias C., Rottmann, Matthias, Freymond, Céline, Brun, Reto, Schweizer, Bernd, Illarionov, Boris, Bacher, Adelbert, Fischer, Markus, Diederich, François, Schneider, Gisbert
Published in Angewandte Chemie (01.07.2014)
Published in Angewandte Chemie (01.07.2014)
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Journal Article
Identification of Pyrrolopyrazinen as polypotente Ligands with antimalarial effect
Reker, Daniel, Seet, Michael, Pillong, Max, Koch, Christian P, Schneider, Petra, Witschel, Matthias C, Rottmann, Matthias, Freymond, Celine, Brun, Reto, Schweizer, Bernd, Illarionov, Boris, Bacher, Adelbert, Fischer, Markus, Diederich, Francois, Schneider, Gisbert
Published in Angewandte Chemie (01.07.2014)
Published in Angewandte Chemie (01.07.2014)
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