In silico repositioning of approved drugs for rare and neglected diseases
Ekins, Sean, Williams, Antony J., Krasowski, Matthew D., Freundlich, Joel S.
Published in Drug discovery today (01.04.2011)
Published in Drug discovery today (01.04.2011)
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Discovery of MRSA active antibiotics using primary sequence from the human microbiome
Chu, John, Vila-Farres, Xavier, Inoyama, Daigo, Ternei, Melinda, Cohen, Louis J, Gordon, Emma A, Reddy, Boojala Vijay B, Charlop-Powers, Zachary, Zebroski, Henry A, Gallardo-Macias, Ricardo, Jaskowski, Mark, Satish, Shruthi, Park, Steven, Perlin, David S, Freundlich, Joel S, Brady, Sean F
Published in Nature chemical biology (01.12.2016)
Published in Nature chemical biology (01.12.2016)
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Morphological profiling of tubercle bacilli identifies drug pathways of action
Smith, Trever C., Pullen, Krista M., Olson, Michaela C., McNellis, Morgan E., Richardson, Ian, Hu, Sophia, Larkins-Ford, Jonah, Wang, Xin, Freundlich, Joel S., Ando, D. Michael, Aldridge, Bree B.
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2020)
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Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection
Lane, Thomas R, Massey, Christopher, Comer, Jason E, Anantpadma, Manu, Freundlich, Joel S, Davey, Robert A, Madrid, Peter B, Ekins, Sean
Published in PLoS neglected tropical diseases (01.11.2019)
Published in PLoS neglected tropical diseases (01.11.2019)
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Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs
Chen, Xueyi, Arun, Bhavatharini, Nino-Meza, Oscar J., Sarhan, Mona O., Singh, Medha, Jeon, Byeonghoon, Mane, Kishor, Shah, Maunank, Tucker, Elizabeth W., Carroll, Laurence S., Freundlich, Joel S., Peloquin, Charles A., Ivaturi, Vijay D., Jain, Sanjay K.
Published in Nature communications (14.08.2024)
Published in Nature communications (14.08.2024)
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Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin
Daher, Samer S., Lee, Miseon, Jin, Xiao, Teijaro, Christiana N., Barnett, Pamela R., Freundlich, Joel S., Andrade, Rodrigo B.
Published in European journal of medicinal chemistry (05.04.2022)
Published in European journal of medicinal chemistry (05.04.2022)
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Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection
Jadhav, Ravindra, Gallardo-Macias, Ricardo, Kumar, Gaurav, Daher, Samer S, Kaushik, Amit, Bigelow, Kristina M, Nuermberger, Eric L, Lamichhane, Gyanu, Freundlich, Joel S
Published in PloS one (03.05.2021)
Published in PloS one (03.05.2021)
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Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF
Waldron, Evan J, Snyder, Daniel, Fernandez, Nicolas L, Sileo, Emily, Inoyama, Daigo, Freundlich, Joel S, Waters, Christopher M, Cooper, Vaughn S, Neiditch, Matthew B
Published in PLoS biology (04.02.2019)
Published in PLoS biology (04.02.2019)
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Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs
Lavin, Richard C., Johnson, Calvin, Ahn, Yong-Mo, Kremiller, Kyle M., Sherwood, Matthew, Patel, Jimmy S., Pan, Yan, Russo, Riccardo, MacGilvary, Nathan J., Giacalone, David, Kevorkian, Yuzo L., Zimmerman, Matthew D., Glickman, J. Fraser, Freundlich, Joel S., Tan, Shumin
Published in PLoS biology (28.07.2021)
Published in PLoS biology (28.07.2021)
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Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters
Vila-Farres, Xavier, Chu, John, Inoyama, Daigo, Ternei, Melinda A, Lemetre, Christophe, Cohen, Louis J, Cho, Wooyoung, Reddy, Boojala Vijay B, Zebroski, Henry A, Freundlich, Joel S, Perlin, David S, Brady, Sean F
Published in Journal of the American Chemical Society (01.02.2017)
Published in Journal of the American Chemical Society (01.02.2017)
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Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design
Rudraraju, Reshma S, Daher, Samer S, Gallardo-Macias, Ricardo, Wang, Xin, Neiditch, Matthew B, Freundlich, Joel S
Published in Frontiers in cellular and infection microbiology (15.09.2022)
Published in Frontiers in cellular and infection microbiology (15.09.2022)
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Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA
Kumar, Pradeep, Capodagli, Glenn C, Awasthi, Divya, Shrestha, Riju, Maharaja, Karishma, Sukheja, Paridhi, Li, Shao-Gang, Inoyama, Daigo, Zimmerman, Matthew, Ho Liang, Hsin Pin, Sarathy, Jansy, Mina, Marizel, Rasic, George, Russo, Riccardo, Perryman, Alexander L, Richmann, Todd, Gupta, Aditi, Singleton, Eric, Verma, Sheetal, Husain, Seema, Soteropoulos, Patricia, Wang, Zhe, Morris, Roxanne, Porter, Gene, Agnihotri, Gautam, Salgame, Padmini, Ekins, Sean, Rhee, Kyu Y, Connell, Nancy, Dartois, Véronique, Neiditch, Matthew B, Freundlich, Joel S, Alland, David
Published in mBio (18.12.2018)
Published in mBio (18.12.2018)
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The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites
Yu, Min, Kumar, T R Santha, Nkrumah, Louis J, Coppi, Alida, Retzlaff, Silke, Li, Celeste D, Kelly, Brendan J, Moura, Pedro A, Lakshmanan, Viswanathan, Freundlich, Joel S, Valderramos, Juan-Carlos, Vilcheze, Catherine, Siedner, Mark, Tsai, Jennifer H-C, Falkard, Brie, Sidhu, Amar Bir Singh, Purcell, Lisa A, Gratraud, Paul, Kremer, Laurent, Waters, Andrew P, Schiehser, Guy, Jacobus, David P, Janse, Chris J, Ager, Arba, Jacobs, Jr, William R, Sacchettini, James C, Heussler, Volker, Sinnis, Photini, Fidock, David A
Published in Cell host & microbe (11.12.2008)
Published in Cell host & microbe (11.12.2008)
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Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads
Anantpadma, Manu, Lane, Thomas, Zorn, Kimberley M, Lingerfelt, Mary A, Clark, Alex M, Freundlich, Joel S, Davey, Robert A, Madrid, Peter B, Ekins, Sean
Published in ACS omega (31.01.2019)
Published in ACS omega (31.01.2019)
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A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis
Forbes, Lauren, Ebsworth-Mojica, Katherine, DiDone, Louis, Li, Shao-Gang, Freundlich, Joel S, Connell, Nancy, Dunman, Paul M, Krysan, Damian J
Published in PloS one (22.06.2015)
Published in PloS one (22.06.2015)
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Novel Inhibitors of InhA Efficiently Kill Mycobacterium tuberculosis under Aerobic and Anaerobic Conditions
VILCHEZE, Catherine, BAUGHN, Anthony D, TUFARIELLO, Joann, LEUNG, Lawrence W, KUO, Mack, BASLER, Christopher F, ALLAND, David, SACCHETTINI, James C, FREUNDLICH, Joel S, JACOBS, William R
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
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Pruned Machine Learning Models to Predict Aqueous Solubility
Perryman, Alexander L, Inoyama, Daigo, Patel, Jimmy S, Ekins, Sean, Freundlich, Joel S
Published in ACS omega (14.07.2020)
Published in ACS omega (14.07.2020)
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