IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
Tahtinen, Siri, Tong, Ann-Jay, Himmels, Patricia, Oh, Jaehak, Paler-Martinez, Andres, Kim, Leesun, Wichner, Sara, Oei, Yoko, McCarron, Mark J., Freund, Emily C., Amir, Zhainib Adel, de la Cruz, Cecile C., Haley, Benjamin, Blanchette, Craig, Schartner, Jill M., Ye, Weilan, Yadav, Mahesh, Sahin, Ugur, Delamarre, Lélia, Mellman, Ira
Published in Nature immunology (01.04.2022)
Published in Nature immunology (01.04.2022)
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Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9
Freund, Emily C, Lock, Jaclyn Y, Oh, Jaehak, Maculins, Timurs, Delamarre, Lelia, Bohlen, Christopher J, Haley, Benjamin, Murthy, Aditya
Published in The Journal of experimental medicine (06.07.2020)
Published in The Journal of experimental medicine (06.07.2020)
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Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing
Freund, Emily C., Sapiro, Anne L., Li, Qin, Linder, Sandra, Moresco, James J., Yates, John R., Li, Jin Billy
Published in Cell reports (Cambridge) (19.05.2020)
Published in Cell reports (Cambridge) (19.05.2020)
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Integration of innate immune signalling by caspase-8 cleavage of N4BP1
Gitlin, Alexander D., Heger, Klaus, Schubert, Alexander F., Reja, Rohit, Yan, Donghong, Pham, Victoria C., Suto, Eric, Zhang, Juan, Kwon, Youngsu C., Freund, Emily C., Kang, Jing, Pham, Anna, Caothien, Roger, Bacarro, Natasha, Hinkle, Trent, Xu, Min, McKenzie, Brent S., Haley, Benjamin, Lee, Wyne P., Lill, Jennie R., Roose-Girma, Merone, Dohse, Monika, Webster, Joshua D., Newton, Kim, Dixit, Vishva M.
Published in Nature (London) (12.11.2020)
Published in Nature (London) (12.11.2020)
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Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage
Tong, Ann-Jay, Leylek, Rebecca, Herzner, Anna-Maria, Rigas, Diamanda, Wichner, Sara, Blanchette, Craig, Tahtinen, Siri, Kemball, Christopher C, Mellman, Ira, Haley, Benjamin, Freund, Emily C, Delamarre, Lélia
Published in The Journal of experimental medicine (05.02.2024)
Published in The Journal of experimental medicine (05.02.2024)
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Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons
Sapiro, Anne L., Freund, Emily C., Restrepo, Lucas, Qiao, Huan-Huan, Bhate, Amruta, Li, Qin, Ni, Jian-Quan, Mosca, Timothy J., Li, Jin Billy
Published in Cell reports (Cambridge) (19.05.2020)
Published in Cell reports (Cambridge) (19.05.2020)
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1130 Design and characterization of novel TLR7-selective ligands with an automated screening platform
Rigas, Diamanda, Freund, Emily, Leylek, Rebecca, Tong, Ann-Jay, Herzner, Anna-Maria, Palace, Shirley Ng, Wichner, Sara, Tahtinen, Siri, Blanchette, Craig, Haley, Benjamin, Delamarre, Lélia, Mellman, Ira, Kemball, Christopher
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Comprehensive Impurity Profiling of mRNA: Evaluating Current Technologies and Advanced Analytical Techniques
Camperi, Julien, Lippold, Steffen, Ayalew, Luladey, Roper, Brian, Shao, Stephanie, Freund, Emily, Nissenbaum, Ariane, Galan, Carolina, Cao, Qinjingwen, Yang, Feng, Yu, Christopher, Guilbaud, Axel
Published in Analytical chemistry (Washington) (05.03.2024)
Published in Analytical chemistry (Washington) (05.03.2024)
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Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses
Camperi, Julien, Roper, Brian, Freund, Emily, Leylek, Rebecca, Nissenbaum, Ariane, Galan, Carolina, Caothien, Roger, Hu, Zhilan, Ko, Peggy, Lee, Allison, Chatla, Kamalakar, Ayalew, Luladey, Yang, Feng, Lippold, Steffen, Guilbaud, Axel
Published in Analytical chemistry (Washington) (05.11.2024)
Published in Analytical chemistry (Washington) (05.11.2024)
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Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
Haag, Simone M., Xie, Shiqi, Eidenschenk, Celine, Fortin, Jean-Philippe, Callow, Marinella, Costa, Mike, Lun, Aaron, Cox, Chris, Wu, Sunny Z., Pradhan, Rachana N., Lock, Jaclyn, Kuhn, Julia A., Holokai, Loryn, Thai, Minh, Freund, Emily, Nissenbaum, Ariane, Keir, Mary, Bohlen, Christopher J., Martin, Scott, Geiger-Schuller, Kathryn, Hejase, Hussein A., Yaspan, Brian L., Melo Carlos, Sandra, Turley, Shannon J., Murthy, Aditya
Published in Nature genetics (23.10.2024)
Published in Nature genetics (23.10.2024)
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일차 골수 세포에서의 효율적인 유전체 편집
HALEY BENJAMIN JOSEPH, MURTHY ADITYA KRISHNA, FREUND EMILY CRANE, LOCK JACLYN, BOHLEN CHRISTOPHER JOHN, OH JAEHAK
Year of Publication 03.11.2022
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Year of Publication 03.11.2022
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OPTIMIZED TLR7 LIGANDS AND USES THEREOF
LEYLEK, Rebecca, HERZNER, Anna-Maria, FREUND, Emily Crane, TONG, Ann-Jay, WICHNER, Sara, DELAMARRE, Lélia Yvonne
Year of Publication 21.02.2024
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Year of Publication 21.02.2024
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EFFICIENT GENOME EDITING IN PRIMARY MYELOID CELLS
LOCK, Jaclyn, HALEY, Benjamin, Joseph, OH, Jaehak, FREUND, Emily, Crane, MURTHY, Aditya, Krishna, BOHLEN, Christopher, John
Year of Publication 17.04.2024
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Year of Publication 17.04.2024
Patent
OPTIMIZED TLR7 LIGANDS AND USES THEREOF
HERZNER, Anna-Maria, LEYLEK, Rebecca Ani, WICHNER, Sara Marie, FREUND, Emily Crane, TONG, Ann-Jay, DELAMARRE, Lélia Yvonne
Year of Publication 08.02.2024
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Year of Publication 08.02.2024
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OPTIMIZED TLR7 LIGANDS AND USES THEREOF
LEYLEK, Rebecca, HERZNER, Anna-Maria, FREUND, Emily Crane, TONG, Ann-Jay, WICHNER, Sara, DELAMARRE, Lélia Yvonne
Year of Publication 05.01.2023
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Year of Publication 05.01.2023
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EFFICIENT GENOME EDITING IN PRIMARY MYELOID CELLS
BOHLEN, Christopher John, LOCK, Jaclyn, HALEY, Benjamin Joseph, OH, Jaehak, FREUND, Emily Crane, MURTHY, Aditya Krishna
Year of Publication 21.09.2023
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Year of Publication 21.09.2023
Patent
OPTIMIZED TLR7 LIGANDS AND USES THEREOF
LEYLEK, Rebecca, HERZNER, Anna-Maria, FREUND, Emily Crane, TONG, Ann-Jay, WICHNER, Sara, DELAMARRE, Lélia Yvonne
Year of Publication 20.10.2022
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Year of Publication 20.10.2022
Patent
EFFICIENT GENOME EDITING IN PRIMARY MYELOID CELLS
LOCK, Jaclyn, HALEY, Benjamin, Joseph, OH, Jaehak, FREUND, Emily, Crane, MURTHY, Aditya, Krishna, BOHLEN, Christopher, John
Year of Publication 04.01.2023
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Year of Publication 04.01.2023
Patent