Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
Hodous, Brian L, Geuns-Meyer, Stephanie D, Hughes, Paul E, Albrecht, Brian K, Bellon, Steve, Bready, James, Caenepeel, Sean, Cee, Victor J, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Rose, Paul, Tempest, Paul, Wang, Ling, Whittington, Douglas A, Zhao, Huilin
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Journal Article
Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors
Hodous, Brian L., Geuns-Meyer, Stephanie D., Hughes, Paul E., Albrecht, Brian K., Bellon, Steve, Caenepeel, Sean, Cee, Victor J., Chaffee, Stuart C., Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Johnson, Rebecca E., Kim, Joseph L., Long, Alexander M., Morrison, Michael, Olivieri, Philip R., Patel, Vinod F., Polverino, Anthony, Rose, Paul, Wang, Ling, Zhao, Huilin
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Journal Article
2-(S)-Phenethylaminothiazolones as Potent, Orally Efficacious Inhibitors of 11β-Hydroxysteriod Dehydrogenase Type 1
St. Jean, David J, Yuan, Chester, Bercot, Eric A, Cupples, Rod, Chen, Michelle, Fretland, Jenne, Hale, Clarence, Hungate, Randall W, Komorowski, Renee, Veniant, Murielle, Wang, Minghan, Zhang, Xiping, Fotsch, Christopher
Published in Journal of medicinal chemistry (08.02.2007)
Published in Journal of medicinal chemistry (08.02.2007)
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Journal Article
Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase
Cee, Victor J., Cheng, Alan C., Romero, Karina, Bellon, Steve, Mohr, Christopher, Whittington, Douglas A., Bak, Annette, Bready, James, Caenepeel, Sean, Coxon, Angela, Deak, Holly L., Fretland, Jenne, Gu, Yan, Hodous, Brian L., Huang, Xin, Kim, Joseph L., Lin, Jasmine, Long, Alexander M., Nguyen, Hanh, Olivieri, Philip R., Patel, Vinod F., Wang, Ling, Zhou, Yihong, Hughes, Paul, Geuns-Meyer, Stephanie
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model
Fotsch, Christopher, Bartberger, Michael D, Bercot, Eric A, Chen, Michelle, Cupples, Rod, Emery, Maury, Fretland, Jenne, Guram, Anil, Hale, Clarence, Han, Nianhe, Hickman, Dean, Hungate, Randall W, Hayashi, Michael, Komorowski, Renee, Liu, Qingyian, Matsumoto, Guy, St. Jean, David J, Ursu, Stefania, Véniant, Murielle, Xu, Guifen, Ye, Qiuping, Yuan, Chester, Zhang, Jiandong, Zhang, Xiping, Tu, Hua, Wang, Minghan
Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase
Cee, Victor J, Albrecht, Brian K, Geuns-Meyer, Stephanie, Hughes, Paul, Bellon, Steve, Bready, James, Caenepeel, Sean, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hodous, Brian L, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, McGowan, David, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Powers, David, Rose, Paul, Wang, Ling, Zhao, Huilin
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Journal Article
2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1
Jean, Jr, David J St, Yuan, Chester, Bercot, Eric A, Cupples, Rod, Chen, Michelle, Fretland, Jenne, Hale, Clarence, Hungate, Randall W, Komorowski, Renee, Veniant, Murielle, Wang, Minghan, Zhang, Xiping, Fotsch, Christopher
Published in Journal of medicinal chemistry (08.02.2007)
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Published in Journal of medicinal chemistry (08.02.2007)
Journal Article
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model
Fotsch, Christopher, Bartberger, Michael D, Bercot, Eric A, Chen, Michelle, Cupples, Rod, Emery, Maury, Fretland, Jenne, Guram, Anil, Hale, Clarence, Han, Nianhe, Hickman, Dean, Hungate, Randall W, Hayashi, Michael, Komorowski, Renee, Liu, Qingyian, Matsumoto, Guy, St Jean, Jr, David J, Ursu, Stefania, Véniant, Murielle, Xu, Guifen, Ye, Qiuping, Yuan, Chester, Zhang, Jiandong, Zhang, Xiping, Tu, Hua, Wang, Minghan
Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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Journal Article