In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417
Haluska, Paul, Carboni, Joan M, Loegering, David A, Lee, Francis Y, Wittman, Mark, Saulnier, Mark G, Frennesson, David B, Kalli, Kimberly R, Conover, Cheryl A, Attar, Ricardo M, Kaufmann, Scott H, Gottardis, Marco, Erlichman, Charles
Published in Cancer research (Chicago, Ill.) (01.01.2006)
Published in Cancer research (Chicago, Ill.) (01.01.2006)
Get full text
Journal Article
Potent Long-Acting Inhibitors Targeting the HIV‑1 Capsid Based on a Versatile Quinazolin-4-one Scaffold
Gillis, Eric P., Parcella, Kyle, Bowsher, Michael, Cook, James H., Iwuagwu, Christiana, Naidu, B. Narasimhulu, Patel, Manoj, Peese, Kevin, Huang, Haichang, Valera, Lourdes, Wang, Chunfu, Kieltyka, Kasia, Parker, Dawn D., Simmermacher, Jean, Arnoult, Eric, Nolte, Robert T., Wang, Liping, Bender, John A., Frennesson, David B., Saulnier, Mark, Wang, Alan Xiangdong, Meanwell, Nicholas A., Belema, Makonen, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Kadow, John F., Cockett, Mark, Fridell, Robert
Published in Journal of medicinal chemistry (09.02.2023)
Published in Journal of medicinal chemistry (09.02.2023)
Get full text
Journal Article
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one
VELAPARTHI, Upender, SAULNIER, Mark G, CLARKE, Wendy, ZHENG YANG, MENARD, Krista, LEE, Francis Y, TRAINOR, George, VYAS, Dolatrai, WITTMAN, Mark D, PEIYING LIU, FRENNESSON, David B, ZIMMERMANN, Kurt, CARBONI, Joan M, GOTTARDIS, Marco, AIXIN LI, GREER, Ann
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Get full text
Journal Article
SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors
Zimmermann, Kurt, Wittman, Mark D., Saulnier, Mark G., Velaparthi, Upender, Sang, Xiaopeng, Frennesson, David B., Struzynski, Charles, Seitz, Steven P., He, Liqi, Carboni, Joan M., Li, Aixin, Greer, Ann F., Gottardis, Marco, Attar, Ricardo M., Yang, Zheng, Balimane, Praveen, Discenza, Lorell N., Lee, Francis Y., Sinz, Michael, Kim, Sean, Vyas, Dolatrai
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Get full text
Journal Article
2-(1 H-Imidazol-4-yl)ethanamine and 2-(1 H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924
Saulnier, Mark G., Frennesson, David B., Wittman, Mark D., Zimmermann, Kurt, Velaparthi, Upender, Langley, David R., Struzynski, Charles, Sang, Xiaopeng, Carboni, Joan, Li, Aixin, Greer, Ann, Yang, Zheng, Balimane, Praveen, Gottardis, Marco, Attar, Ricardo, Vyas, Dolatrai
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
Get full text
Journal Article
Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11
Saulnier, Mark G, Balasubramanian, Balu N, Long, Byron H, Frennesson, David B, Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T, St. Laurent, Denis R, Stoffan, Karen M, Naidu, B. Narasimhulu, Mahler, Mikael, Beaulieu, Francis, Bachand, Carol, Lee, Frank Y, Fairchild, Craig R, Stadnick, Linda K, Rose, William C, Solomon, Carola, Wong, Henry, Martel, Alain, Wright, John J, Kramer, Robert, Langley, David R, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
Get full text
Journal Article
키나제 억제제로서의 트리아졸로피리디닐 화합물
GUO JUNQING, SHI JIANLIANG, SPERGEL STEVEN H, PATTON MATTHEW REISER, MERTZMAN MICHAEL E, YANG MICHAEL G, DZIERBA CAROLYN DIANE, CHEN JIE, XIAO ZILI, LUO GUANGLIN, HU XIRUI, HART AMY C, VENABLES BRIAN LEE, FRENNESSON DAVID B, WU YONG JIN
Year of Publication 26.06.2023
Get full text
Year of Publication 26.06.2023
Patent
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
Get full text
Journal Article
면역조정제로서 유용한 1,3-디히드록시-페닐 유도체
YEUNG KAP SUN, ZHU JULIANG, SAULNIER MARK G, GRANT YOUNG KATHARINE A, SCOLA PAUL MICHAEL, MENG ZHAOXING, FRENNESSON DAVID B
Year of Publication 13.03.2019
Get full text
Year of Publication 13.03.2019
Patent
면역조정제로서 유용한 비아릴 화합물
YEUNG KAP SUN, ZHU JULIANG, MULL ERIC, SAULNIER MARK G, WANG TAO, SCOLA PAUL MICHAEL, HEWAWASAM PIYASENA, MENG ZHAOXING, GRANT YOUNG KATHARINE A, FRENNESSON DAVID B, SUN LI QIANG, LANGLEY DAVID R, ZHANG ZHONGXING
Year of Publication 26.04.2019
Get full text
Year of Publication 26.04.2019
Patent
면역조정제로서 유용한 화합물
YEUNG KAP SUN, MULL ERIC, ZHU JULIANG, SCOLA PAUL MICHAEL, HEWAWASAM PIYASENA, XU NINGNING, CONNOLLY TIMOTHY P, MENG ZHAOXING, SAULNIER MARK GEORGE, WANG ALAN XIANGDONG, GRANT YOUNG KATHARINE A, FRENNESSON DAVID B, SUN LI QIANG, LANGLEY DAVID R, PARCELLA KYLE E
Year of Publication 07.06.2018
Get full text
Year of Publication 07.06.2018
Patent
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Wright, John J, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
Get full text
Journal Article
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1 H-benzimidazol-2-yl]-1 H-pyridine-2-one
Velaparthi, Upender, Saulnier, Mark G., Wittman, Mark D., Liu, Peiying, Frennesson, David B., Zimmermann, Kurt, Carboni, Joan M., Gottardis, Marco, Li, Aixin, Greer, Ann, Clarke, Wendy, Yang, Zheng, Menard, Krista, Lee, Francis Y., Trainor, George, Vyas, Dolatrai
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
Get full text
Journal Article
Microwave-assisted synthesis of primary amine HX salts from halides and 7 M ammonia in methanol
Saulnier, MG, Zimmermann, K, Struzynski, CP, Sang, XP, Velaparthi, U, Wittman, M, Frennesson, DB
Published in Tetrahedron letters (05.01.2004)
Published in Tetrahedron letters (05.01.2004)
Get full text
Journal Article
Novel 3 ',6 '-anhydro and N12,N13-bridged glycosylated fluoroindolo[2,3-a]carbazoles as topoisomerase I inhibitors. Fluorine as a leaving group from sp(3) carbon
Saulnier, MG, Langley, DR, Frennesson, DB, Long, BH, Huang, S, Gao, Q, Wu, DD, Fairchild, CR, Ruediger, E, Zimmermann, K, St Laurent, DR, Balasubramanian, BN, Vyas, DM
Published in Organic letters (31.03.2005)
Published in Organic letters (31.03.2005)
Get full text
Journal Article
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-Ι/insulin receptor inhibitor, BMS-554417
HALUSKA, Paul, CARBONI, Joan M, KAUFMANN, Scott H, GOTTARDIS, Marco, ERLICHMAN, Charles, LOEGERING, David A, LEE, Francis Y, WITTMAN, Mark, SAULNIER, Mark G, FRENNESSON, David B, KALLI, Kimberly R, CONOVER, Cheryl A, ATTAR, Ricardo M
Published in Cancer research (Chicago, Ill.) (2006)
Get full text
Published in Cancer research (Chicago, Ill.) (2006)
Journal Article
Novel 3‘,6‘-Anhydro and N12,N13-Bridged Glycosylated Fluoroindolo[2,3-a]carbazoles as Topoisomerase I Inhibitors. Fluorine as a Leaving Group from sp3 Carbon
Saulnier, Mark G, Langley, David R, Frennesson, David B, Long, Byron H, Huang, Stella, Gao, Qi, Wu, Dedong, Fairchild, Craig R, Ruediger, Edward, Zimmermann, Kurt, St. Laurent, Denis R, Balasubramanian, Balu N, Vyas, Dolatrai M
Published in Organic letters (31.03.2005)
Published in Organic letters (31.03.2005)
Get full text
Journal Article