Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies
White, Ann L., Chan, H.T. Claude, French, Ruth R., Willoughby, Jane, Mockridge, C. Ian, Roghanian, Ali, Penfold, Christine A., Booth, Steven G., Dodhy, Ali, Polak, Marta E., Potter, Elizabeth A., Ardern-Jones, Michael R., Verbeek, J. Sjef, Johnson, Peter W.M., Al-Shamkhani, Aymen, Cragg, Mark S., Beers, Stephen A., Glennie, Martin J.
Published in Cancer cell (12.01.2015)
Published in Cancer cell (12.01.2015)
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Mechanisms of killing by anti-CD20 monoclonal antibodies
Glennie, Martin J., French, Ruth R., Cragg, Mark S., Taylor, Ronald P.
Published in Molecular immunology (01.09.2007)
Published in Molecular immunology (01.09.2007)
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Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy
Lim, Sean H., Vaughan, Andrew T., Ashton-Key, Margaret, Williams, Emily L., Dixon, Sandra V., Chan, H. T. Claude, Beers, Stephen A., French, Ruth R., Cox, Kerry L., Davies, Andrew J., Potter, Kathleen N., Mockridge, C. Ian, Oscier, David G., Johnson, Peter W.M., Cragg, Mark S., Glennie, Martin J.
Published in Blood (01.09.2011)
Published in Blood (01.09.2011)
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Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
Beers, Stephen A., French, Ruth R., Chan, H.T. Claude, Lim, Sean H., Jarrett, Timothy C., Vidal, Regina Mora, Wijayaweera, Sahan S., Dixon, Sandra V., Kim, Hyungjin, Cox, Kerry L., Kerr, Jonathan P., Johnston, David A., Johnson, Peter W.M., Verbeek, J. Sjef, Glennie, Martin J., Cragg, Mark S.
Published in Blood (24.06.2010)
Published in Blood (24.06.2010)
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Anti-CD20 monoclonal antibodies: historical and future perspectives
LIM, Sean H, BEERS, Stephen A, FRENCH, Ruth R, JOHNSON, Peter W. M, GLENNIE, Martin J, CRAGG, Mark S
Published in Haematologica (Roma) (01.01.2010)
Published in Haematologica (Roma) (01.01.2010)
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CD20 as a target for therapeutic type I and II monoclonal antibodies
Beers, Stephen A, Chan, Claude H T, French, Ruth R, Cragg, Mark S, Glennie, Martin J
Published in Seminars in hematology (01.04.2010)
Published in Seminars in hematology (01.04.2010)
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The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20
Teeling, Jessica L, Mackus, Wendy J. M, Wiegman, Luus J. J. M, van den Brakel, Jeroen H. N, Beers, Stephen A, French, Ruth R, van Meerten, Tom, Ebeling, Saskia, Vink, Tom, Slootstra, Jerry W, Parren, Paul W. H. I, Glennie, Martin J, van de Winkel, Jan G. J
Published in Journal of Immunology (01.07.2006)
Published in Journal of Immunology (01.07.2006)
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Induction of Cytosolic Calcium Flux by CD20 Is Dependent upon B Cell Antigen Receptor Signaling
Walshe, Claire A., Beers, Stephen A., French, Ruth R., Chan, Claude H.T., Johnson, Peter W., Packham, Graham K., Glennie, Martin J., Cragg, Mark S.
Published in The Journal of biological chemistry (20.06.2008)
Published in The Journal of biological chemistry (20.06.2008)
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CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses
Castro, Fernanda V.V, Tutt, Alison L, White, Ann L, Teeling, Jessica L, James, Sonya, French, Ruth R, Glennie, Martin J
Published in European journal of immunology (01.08.2008)
Published in European journal of immunology (01.08.2008)
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TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
Yu, Xiaojie, James, Sonya, Felce, James H., Kellermayer, Blanka, Johnston, David A., Chan, H. T. Claude, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, Watanabe, Yasunori, Crispin, Max, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., Glennie, Martin J., Cragg, Mark S.
Published in Communications biology (23.06.2021)
Published in Communications biology (23.06.2021)
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On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation
Sopp, Joshua M., Peters, Shirley J., Rowley, Tania F., Oldham, Robert J., James, Sonya, Mockridge, Ian, French, Ruth R., Turner, Alison, Beers, Stephen A., Humphreys, David P., Cragg, Mark S.
Published in Communications biology (02.09.2021)
Published in Communications biology (02.09.2021)
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Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity
Yu, Xiaojie, Chan, H.T. Claude, Fisher, Hayden, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., English, Vikki, Verbeek, J. Sjef, White, Ann L., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.
Published in Cancer cell (08.06.2020)
Published in Cancer cell (08.06.2020)
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Journal Article
Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies
Yu, Xiaojie, Chan, H.T. Claude, Orr, Christian M., Dadas, Osman, Booth, Steven G., Dahal, Lekh N., Penfold, Christine A., O'Brien, Lyn, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick, Douglas, Leon R., Pearson, Arwen R., Cragg, Mark S., Tews, Ivo, Glennie, Martin J., White, Ann L.
Published in Cancer cell (09.04.2018)
Published in Cancer cell (09.04.2018)
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OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential
Lai, Chester, August, Suzannah, Albibas, Amel, Behar, Ramnik, Cho, Shin-Young, Polak, Marta E, Theaker, Jeffrey, MacLeod, Amanda S, French, Ruth R, Glennie, Martin J, Al-Shamkhani, Aymen, Healy, Eugene
Published in Clinical cancer research (15.08.2016)
Published in Clinical cancer research (15.08.2016)
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Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody
White, Ann L, Chan, H T Claude, Roghanian, Ali, French, Ruth R, Mockridge, C Ian, Tutt, Alison L, Dixon, Sandra V, Ajona, Daniel, Verbeek, J Sjef, Al-Shamkhani, Aymen, Cragg, Mark S, Beers, Stephen A, Glennie, Martin J
Published in The Journal of immunology (1950) (15.08.2011)
Published in The Journal of immunology (1950) (15.08.2011)
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Journal Article
Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies
Tipton, Thomas R.W., Roghanian, Ali, Oldham, Robert J., Carter, Matthew J., Cox, Kerry L., Mockridge, C. Ian, French, Ruth R., Dahal, Lekh N., Duriez, Patrick J., Hargreaves, Philip G., Cragg, Mark S., Beers, Stephen A.
Published in Blood (19.03.2015)
Published in Blood (19.03.2015)
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Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation
Beers, Stephen A., Chan, Claude H.T., James, Sonya, French, Ruth R., Attfield, Kathrine E., Brennan, Claire M., Ahuja, Anupama, Shlomchik, Mark J., Cragg, Mark S., Glennie, Martin J.
Published in Blood (15.11.2008)
Published in Blood (15.11.2008)
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Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking
Turaj, Anna H., Cox, Kerry L., Penfold, Christine A., French, Ruth R., Mockridge, C. Ian, Willoughby, Jane E., Tutt, Alison L., Griffiths, Jordana, Johnson, Peter W. M., Glennie, Martin J., Levy, Ronald, Cragg, Mark S., Lim, Sean H.
Published in Scientific reports (02.02.2018)
Published in Scientific reports (02.02.2018)
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A new anti-idiotype antibody capable of binding rituximab on the surface of lymphoma cells
Cragg, Mark S., Bayne, Mike B., Tutt, Alison L., French, Ruth R., Beers, Stephen, Glennie, Martin J., Illidge, Timothy M.
Published in Blood (15.10.2004)
Published in Blood (15.10.2004)
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Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody‐dependent cell‐mediated cytotoxicity and complement‐dependent cytotoxicity
Lohse, Stefan, Loew, Sebastian, Kretschmer, Anna, Jansen, J. H. Marco, Meyer, Saskia, ten Broeke, Toine, Rösner, Thies, Dechant, Michael, Derer, Stefanie, Klausz, Katja, Kellner, Christian, Schwanbeck, Ralf, French, Ruth R., Tipton, Thomas R. W., Cragg, Mark S., Schewe, Denis M., Peipp, Matthias, Leusen, Jeanette H. W., Valerius, Thomas
Published in British journal of haematology (01.05.2018)
Published in British journal of haematology (01.05.2018)
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