Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration
Ramaswami, Gokul, Yuva-Aydemir, Yeliz, Akerberg, Brynn, Matthews, Bryan, Williams, Jenna, Golczer, Gabriel, Huang, Jiaqi, Al Abdullatif, Ali, Huh, Dann, Burkly, Linda C., Engle, Sandra J., Grossman, Iris, Sehgal, Alfica, Sigova, Alla A., Fremeau, Robert T., Liu, Yuting, Bumcrot, David
Published in Scientific reports (25.01.2024)
Published in Scientific reports (25.01.2024)
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Vesicular Glutamate Transporters 1 and 2 Target to Functionally Distinct Synaptic Release Sites
Fremeau, Robert T., Kam, Kaiwen, Qureshi, Tayyaba, Johnson, Juliette, Copenhagen, David R., Storm-Mathisen, Jon, Chaudhry, Farrukh A., Nicoll, Roger A., Edwards, Robert H.
Published in Science (American Association for the Advancement of Science) (18.06.2004)
Published in Science (American Association for the Advancement of Science) (18.06.2004)
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Author Correction: Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration
Ramaswami, Gokul, Yuva-Aydemir, Yeliz, Akerberg, Brynn, Matthews, Bryan, Williams, Jenna, Golczer, Gabriel, Huang, Jiaqi, Al Abdullatif, Ali, Huh, Dann, Burkly, Linda C., Engle, Sandra J., Grossman, Iris, Sehgal, Alfica, Sigova, Alla A., Fremeau, Robert T., Liu, Yuting, Bumcrot, David
Published in Scientific reports (23.04.2024)
Published in Scientific reports (23.04.2024)
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VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
Fremeau, Robert T, Voglmaier, Susan, Seal, Rebecca P, Edwards, Robert H
Published in Trends in neurosciences (Regular ed.) (01.02.2004)
Published in Trends in neurosciences (Regular ed.) (01.02.2004)
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From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)
Cheng, Yuan, Judd, Ted C, Bartberger, Michael D, Brown, James, Chen, Kui, Fremeau, Robert T, Hickman, Dean, Hitchcock, Stephen A, Jordan, Brad, Li, Vivian, Lopez, Patricia, Louie, Steven W, Luo, Yi, Michelsen, Klaus, Nixey, Thomas, Powers, Timothy S, Rattan, Claire, Sickmier, E. Allen, St. Jean, David J, Wahl, Robert C, Wen, Paul H, Wood, Stephen
Published in Journal of medicinal chemistry (25.08.2011)
Published in Journal of medicinal chemistry (25.08.2011)
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The Identification of Vesicular Glutamate Transporter 3 Suggests Novel Modes of Signaling by Glutamate
Fremeau, Robert T., Burman, Jonathon, Qureshi, Tayyaba, Tran, Cindy H., Proctor, John, Johnson, Juliette, Zhang, Hui, Sulzer, David, Copenhagen, David R., Storm-Mathisen, Jon, Reimer, Richard J., Chaudhry, Farrukh A., Edwards, Robert H.
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2002)
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Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease
Huang, Hongbing, La, Daniel S, Cheng, Alan C, Whittington, Douglas A, Patel, Vinod F, Chen, Kui, Dineen, Thomas A, Epstein, Oleg, Graceffa, Russell, Hickman, Dean, Kiang, Y.-H, Louie, Steven, Luo, Yi, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Fremeau, Robert T
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters
Boulland, Jean-Luc, Qureshi, Tayyaba, Seal, Rebecca P., Rafiki, Amina, Gundersen, Vidar, Bergersen, Linda H., Fremeau Jr, Robert T., Edwards, Robert H., Storm-Mathisen, Jon, Chaudhry, Farrukh A.
Published in Journal of comparative neurology (1911) (13.12.2004)
Published in Journal of comparative neurology (1911) (13.12.2004)
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The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse
Fremeau, Robert T, Troyer, Matthew D, Pahner, Ingrid, Nygaard, Gro Owren, Tran, Cindy H, Reimer, Richard J, Bellocchio, Elizabeth E, Fortin, Doris, Storm-Mathisen, Jon, Edwards, Robert H
Published in Neuron (Cambridge, Mass.) (02.08.2001)
Published in Neuron (Cambridge, Mass.) (02.08.2001)
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Distribution of vesicular glutamate transporters 1 and 2 in the rat spinal cord, with a note on the spinocervical tract
Persson, Stefan, Boulland, Jean-Luc, Aspling, Marie, Larsson, Max, Fremeau Jr, Robert T., Edwards, Robert H., Storm-Mathisen, Jon, Chaudhry, Farrukh A., Broman, Jonas
Published in Journal of comparative neurology (1911) (10.08.2006)
Published in Journal of comparative neurology (1911) (10.08.2006)
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Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors
Epstein, Oleg, Bryan, Marian C, Cheng, Alan C, Derakhchan, Katayoun, Dineen, Thomas A, Hickman, Dean, Hua, Zihao, Human, Jason B, Kreiman, Charles, Marx, Isaac E, Weiss, Matthew M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Zheng, Xiao Mei, Fremeau, Robert T, White, Ryan D, Patel, Vinod F
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement
Marx, Isaac E, Dineen, Thomas A, Able, Jessica, Bode, Christiane, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F, Du, Bingfan, Foti, Robert S, Fremeau, Robert T, Gao, Hua, Gunaydin, Hakan, Hall, Brian E, Huang, Liyue, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Lin, Min-Hwa Jasmine, Liu, Dong, McDermott, Jeff S, Moyer, Bryan D, Peterson, Emily A, Roberts, Jonathan T, Rose, Paul, Wang, Jean, Youngblood, Beth D, Yu, Violeta, Weiss, Matthew M
Published in ACS medicinal chemistry letters (08.12.2016)
Published in ACS medicinal chemistry letters (08.12.2016)
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Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists
Biswas, Kaustav, Peterkin, Tanya A. N, Bryan, Marian C, Arik, Leyla, Lehto, Sonya G, Sun, Hong, Hsieh, Feng-Yin, Xu, Cen, Fremeau, Robert T, Allen, Jennifer R
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina
Johnson, Juliette, Sherry, David M., Liu, Xiaorong, Fremeau Jr, Robert T., Seal, Rebecca P., Edwards, Robert H., Copenhagen, David R.
Published in Journal of comparative neurology (1911) (27.09.2004)
Published in Journal of comparative neurology (1911) (27.09.2004)
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Vesicular Glutamate Transporter 1 Is Required for Photoreceptor Synaptic Signaling But Not For Intrinsic Visual Functions
Johnson, Juliette, Fremeau, Robert T., Jr, Duncan, Jacque L, Renteria, Rene C, Yang, Haidong, Hua, Zhaolin, Liu, Xiaorong, LaVail, Matthew M, Edwards, Robert H, Copenhagen, David R
Published in The Journal of neuroscience (04.07.2007)
Published in The Journal of neuroscience (04.07.2007)
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Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists
Cheng, Yuan, Albrecht, Brian K, Brown, James, Buchanan, John L, Buckner, William H, DiMauro, Erin F, Emkey, Renee, Fremeau, Robert T, Harmange, Jean-Christophe, Hoffman, Beth J, Huang, Liyue, Huang, Ming, Lee, Josie Han, Lin, Fen-Fen, Martin, Matthew W, Nguyen, Hung Q, Patel, Vinod F, Tomlinson, Susan A, White, Ryan D, Xia, Xiaoyang, Hitchcock, Stephen A
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease
Chen, Jian Jeffrey, Liu, Qingyian, Yuan, Chester, Gore, Vijay, Lopez, Patricia, Ma, Vu, Amegadzie, Albert, Qian, Wenyuan, Judd, Ted C., Minatti, Ana E., Brown, James, Cheng, Yuan, Xue, May, Zhong, Wenge, Dineen, Thomas A., Epstein, Oleg, Human, Jason, Kreiman, Charles, Marx, Isaac, Weiss, Matthew M., Hitchcock, Stephen A., Powers, Timothy S., Chen, Kui, Wen, Paul H., Whittington, Douglas A., Cheng, Alan C., Bartberger, Michael D., Hickman, Dean, Werner, Jonathan A., Vargas, Hugo M., Everds, Nancy E., Vonderfecht, Steven L., Dunn, Robert T., Wood, Stephen, Fremeau, Robert T., White, Ryan D., Patel, Vinod F.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Endocannabinoid-Independent Retrograde Signaling at Inhibitory Synapses in Layer 2/3 of Neocortex: Involvement of Vesicular Glutamate Transporter 3
Harkany, Tibor, Holmgren, Carl, Hartig, Wolfgang, Qureshi, Tayyaba, Chaudhry, Farrukh A, Storm-Mathisen, Jon, Dobszay, Marton B, Berghuis, Paul, Schulte, Gunnar, Sousa, Kyle M, Fremeau, Robert T., Jr, Edwards, Robert H, Mackie, Ken, Ernfors, Patrik, Zilberter, Yuri
Published in The Journal of neuroscience (26.05.2004)
Published in The Journal of neuroscience (26.05.2004)
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An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities
Cheng, Yuan, Brown, James, Judd, Ted C, Lopez, Patricia, Qian, Wenyuan, Powers, Timothy S, Chen, Jian Jeffrey, Bartberger, Michael D, Chen, Kui, Dunn, Robert T, Epstein, Oleg, Fremeau, Robert T, Harried, Scott, Hickman, Dean, Hitchcock, Stephen A, Luo, Yi, Minatti, Ana Elena, Patel, Vinod F, Vargas, Hugo M, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, White, Ryan D, Whittington, Douglas A, Zheng, Xiao Mei, Wood, Stephen
Published in ACS medicinal chemistry letters (12.02.2015)
Published in ACS medicinal chemistry letters (12.02.2015)
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