Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design
Nuotio, Marja-Liisa, Sánez Tähtisalo, Heini, Lahtinen, Alexandra, Donner, Kati, Fyhrquist, Frej, Perola, Markus, Kontula, Kimmo K, Hiltunen, Timo P
Published in Epigenetics (02.11.2022)
Published in Epigenetics (02.11.2022)
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Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses
Sánez Tähtisalo, Heini, Ruotsalainen, Sanni, Mars, Nina, Porthan, Kimmo, Oikarinen, Lasse, Virolainen, Juha, Fyhrquist, Frej, Ripatti, Samuli, Kontula, Kimmo K., Hiltunen, Timo P.
Published in Scientific reports (20.07.2020)
Published in Scientific reports (20.07.2020)
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The impact of serum uric acid on cardiovascular outcomes in the LIFE study
Høieggen, Aud, Alderman, Michael H., Kjeldsen, Sverre E., Julius, Stevo, Devereux, Richard B., de Faire, Ulf, Fyhrquist, Frej, Ibsen, Hans, Kristianson, Krister, Lederballe-Pedersen, Ole, Lindholm, Lars H., Nieminen, Markku S., Omvik, Per, Oparil, Suzanne, Wedel, Hans, Chen, Cong, Dahlöf, Björn, for the LIFE Study Group
Published in Kidney international (01.03.2004)
Published in Kidney international (01.03.2004)
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Genome-Wide Meta-Analysis of Blood Pressure Response to β1-Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies)
Singh, Sonal, Warren, Helen R, Hiltunen, Timo P, McDonough, Caitrin W, El Rouby, Nihal, Salvi, Erika, Wang, Zhiying, Garofalidou, Tatiana, Fyhrquist, Frej, Kontula, Kimmo K, Glorioso, Valeria, Zaninello, Roberta, Glorioso, Nicola, Pepine, Carl J, Munroe, Patricia B, Turner, Stephan T, Chapman, Arlene B, Boerwinkle, Eric, Johnson, Julie A, Gong, Yan, Cooper-DeHoff, Rhonda M
Published in Journal of the American Heart Association (20.08.2019)
Published in Journal of the American Heart Association (20.08.2019)
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Effects of Randomized Controlled Infancy-Onset Dietary Intervention on Leukocyte Telomere Length-The Special Turku Coronary Risk Factor Intervention Project (STRIP)
Pitkänen, Niina, Pahkala, Katja, Rovio, Suvi P, Saijonmaa, Outi J, Nyman, Anna E, Jula, Antti, Lagström, Hanna, Viikari, Jorma S A, Rönnemaa, Tapani, Niinikoski, Harri, Simell, Olli, Fyhrquist, Frej, Raitakari, Olli T
Published in Nutrients (22.01.2021)
Published in Nutrients (22.01.2021)
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P36 Leukocyte Telomere Length is Inversely Associated with Wave Reflection in 566 Normotensive and Never-treated Hypertensive Subjects
Pörsti, Ilkka, Honkonen, Milja, Vääräniemi, Kati, Saijonmaa, Outi, Tikkakoski, Antti, Koskela, Jenni, Eräranta, Arttu, Kähönen, Mika, Mustonen, Jukka, Fyhrquist, Frej
Published in Artery research (01.02.2020)
Published in Artery research (01.02.2020)
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Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study
Lindholm, Lars H, Ibsen, Hans, Borch-Johnsen, Knut, Olsen, Michael Hecht, Wachtell, Kristian, Dahlöf, Björn, Devereux, Richard B, Beevers, Gareth, de Faire, Ulf, Fyhrquist, Frej, Julius, Stevo, Kjeldsen, Sverre E, Kristianson, Krister, Lederballe-Pedersen, Ole, Nieminen, Markku S, Omvik, Per, Oparil, Suzanne, Wedel, Hans, Aurup, Peter, Edelman, Jonathan M, Snapinn, Steven
Published in Journal of hypertension (01.09.2002)
Published in Journal of hypertension (01.09.2002)
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Basic Biology of Oxidative Stress and the Cardiovascular System
Sack, Michael N., Fyhrquist, Frej Y., Saijonmaa, Outi J., Fuster, Valentin, Kovacic, Jason C.
Published in Journal of the American College of Cardiology (01.07.2017)
Published in Journal of the American College of Cardiology (01.07.2017)
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Journal Article
Effect of ACE insertion/deletion and 12 other polymorphisms on clinical outcomes and response to treatment in the LIFE study
Nordestgaard, Børge G, Kontula, Kimmo, Benn, Marianne, Dahlöf, Björn, de Faire, Ulf, Edelman, Jonathan M, Eliasson, Erik, Fyhrquist, Frej, Hille, Darcy A, Ibsen, Hans, Lyle, Paulette A, Berg, Kåre, Sandberg, Mia, Sethi, Amar A, Wong, Peggy H, Os, Ingrid
Published in Pharmacogenetics and genomics (01.02.2010)
Published in Pharmacogenetics and genomics (01.02.2010)
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The roles of senescence and telomere shortening in cardiovascular disease
Fyhrquist, Frej, Saijonmaa, Outi, Strandberg, Timo
Published in Nature reviews cardiology (01.05.2013)
Published in Nature reviews cardiology (01.05.2013)
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Journal Article
Prognostic importance of hemoglobin in hypertensive patients with electrocardiographic left ventricular hypertrophy: The Losartan Intervention For End point reduction in hypertension (LIFE) study
Olsen, Michael Hecht, MD, PhD, Wachtell, Kristian, MD, PhD, Beevers, Gareth, MD, Dahlöf, Björn, MD, PhD, Devereux, Richard B., MD, de Faire, Ulf, MD, PhD, Fyhrquist, Frej, MD, PhD, Ibsen, Hans, MD, PhD, Kjeldsen, Sverre E., MD, PhD, Lederballe-Pedersen, Ole, MD, PhD, Lindholm, Lars H., MD, Narayan, Puneet, MD, Nieminen, Markku S., MD, Omvik, Per, MD, PhD, Oparil, Suzanne, MD, Wedel, Hans, PhD
Published in The American heart journal (2009)
Published in The American heart journal (2009)
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Activated Mast Cells Increase the Level of Endothelin-1 mRNA in Cocultured Endothelial Cells and Degrade the Secreted Peptide
Metsärinne, Kaj P, Vehmaan-Kreula, Pirjo, Kovanen, Petri T, Saijonmaa, Outi, Baumann, Marc, Wang, Yenfeng, Nyman, Tuulikki, Fyhrquist, Frej Y, Eklund, Kari K
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2002)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.2002)
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Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension
Hannila-Handelberg, Tuula, Kontula, Kimmo, Tikkanen, Ilkka, Tikkanen, Tuula, Fyhrquist, Frej, Helin, Karri, Fodstad, Heidi, Piippo, Kirsi, Miettinen, Helena E, Virtamo, Jarmo, Krusius, Tom, Sarna, Seppo, Gautschi, Ivan, Schild, Laurent, Hiltunen, Timo P
Published in BMC medical genetics (20.01.2005)
Published in BMC medical genetics (20.01.2005)
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Response
Fyhrquist, Frej, Devereux, Richard B., Kjeldsen, Sverre E., Dahlöf, Björn
Published in Hypertension (Dallas, Tex. 1979) (01.01.2019)
Published in Hypertension (Dallas, Tex. 1979) (01.01.2019)
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