Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
Geiger, Martina, Stubenrauch, Kay-Gunnar, Sam, Johannes, Richter, Wolfgang F., Jordan, Gregor, Eckmann, Jan, Hage, Carina, Nicolini, Valeria, Freimoser-Grundschober, Anne, Ritter, Mirko, Lauer, Matthias E., Stahlberg, Henning, Ringler, Philippe, Patel, Jigar, Sullivan, Eric, Grau-Richards, Sandra, Endres, Stefan, Kobold, Sebastian, Umaña, Pablo, Brünker, Peter, Klein, Christian
Published in Nature communications (24.06.2020)
Published in Nature communications (24.06.2020)
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Journal Article
FcγRIIIa chromatography to enrich a-fucosylated glycoforms and assess the potency of glycoengineered therapeutic antibodies
Freimoser–Grundschober, Anne, Rueger, Petra, Fingas, Felix, Sondermann, Peter, Herter, Sylvia, Schlothauer, Tilman, Umana, Pablo, Neumann, Christiane
Published in Journal of Chromatography A (11.01.2020)
Published in Journal of Chromatography A (11.01.2020)
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Journal Article
Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
Waldhauer, Inja, Gonzalez-Nicolini, Valeria, Freimoser-Grundschober, Anne, Nayak, Tapan K, Fahrni, Linda, Hosse, Ralf J, Gerrits, Danny, Geven, Edwin J W, Sam, Johannes, Lang, Sabine, Bommer, Esther, Steinhart, Virginie, Husar, Elisabeth, Colombetti, Sara, Van Puijenbroek, Erwin, Neubauer, Markus, Cline, J Mark, Garg, Pradeep K, Dugan, Gregory, Cavallo, Federica, Acuna, Gonzalo, Charo, Jehad, Teichgräber, Volker, Evers, Stefan, Boerman, Otto C, Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo, Klein, Christian
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane
Published in eLife (11.08.2021)
Published in eLife (11.08.2021)
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Characterization of anti-drug antibody responses to the T-cell engaging bispecific antibody cibisatamab to understand the impact on exposure
Lotz, Gregor P, Lutz, Achim, Martin-Facklam, Meret, Hansbauer, Andre, Schick, Eginhard, Moessner, Ekkehard, Antony, Michael, Stuchly, Thomas, Viert, Maria, Hosse, Ralf J, Freimoser-Grundschober, Anne, Klein, Christian, Schäfer, Martin, Ritter, Mirko, Stubenrauch, Kay-Gunnar
Published in Frontiers in immunology (31.05.2024)
Published in Frontiers in immunology (31.05.2024)
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JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy
Leclercq, Gabrielle, Haegel, Hélène, Toso, Alberto, Zimmermann, Tina, Green, Luke, Steinhoff, Nathalie, Sam, Johannes, Pulko, Vesna, Schneider, Anneliese, Giusti, Anna Maria, Challier, John, Freimoser-Grundschober, Anne, Larivière, Laurent, Odermatt, Alex, Stern, Martin, Umana, Pablo, Bacac, Marina, Klein, Christian
Published in Journal for immunotherapy of cancer (01.01.2022)
Published in Journal for immunotherapy of cancer (01.01.2022)
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Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors
Stock, Sophia, Benmebarek, Mohamed-Reda, Kluever, Anna-Kristina, Darowski, Diana, Jost, Christian, Stubenrauch, Kay-Gunnar, Benz, Joerg, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Umana, Pablo, Subklewe, Marion, Endres, Stefan, Klein, Christian, Kobold, Sebastian
Published in Journal for immunotherapy of cancer (01.07.2022)
Published in Journal for immunotherapy of cancer (01.07.2022)
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Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo
Published in Oncoimmunology (04.03.2017)
Published in Oncoimmunology (04.03.2017)
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Journal Article
이종이량체 Fc 도메인 항체
KLEIN CHRISTIAN, DAROWSKI DIANA, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 20.03.2024
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Year of Publication 20.03.2024
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개선된 항원 결합 수용체
KLEIN CHRISTIAN, DAROWSKI DIANA, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 28.03.2023
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Year of Publication 28.03.2023
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Novel Tumor-Targeted, Engineered IL-2 Variant (IL2v)-Based Immunocytokines For Immunotherapy Of Cancer
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria, Dunn, Claire, Freimoser-Grundschober, Anne, Danny, Gerrits, Boerman, Otto, Nayak, Tapan, Herter, Sylvia, Van Puijenbroek, Erwin, Ast, Oliver, Hofer, Thomas, Hosse, Ralf, Lang, Sabine, Neumann, Sebastian, Kettenberger, Hubert, Neubauer, Markus, Gorr, Ingo, Tuerck, Dietrich, Evers, Stefan, Gerdes, Christian, Levitsky, Victor, Bacac, Marina, Moessner, Ekkehard, Umana, Pablo
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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CD3 ANTIBODIES BINDING TO CD3
NICOLINI VALERIA G, TROCHANOWSKA HALINA, HOFER THOMAS, UMANA PABLO, RICHTER WOLFGANG, WALDHAUER INJA, KNAUPP ALEXANDER, HOSSE RALF, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 28.10.2024
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Year of Publication 28.10.2024
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개선된 항원 결합 수용체
CHEN GUOZHI, XU DAN, KLEIN CHRISTIAN, DAROWSKI DIANA, XU WEI, MOESSNER EKKEHARD, WEI HUAFENG, FREIMOSER GRUNDSCHOBER ANNE
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Year of Publication 22.02.2023
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Year of Publication 22.02.2023
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Year of Publication 22.02.2023
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Year of Publication 22.02.2023
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면역접합체
CODARRI DEAK LAURA, SCHULENBURG CINDY, KLEIN CHRISTIAN, UMANA PABLO, VARYPATAKI ELENI MARIA, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE, LAUENER LAURA
Year of Publication 06.01.2023
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Year of Publication 06.01.2023
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항-HLA-G 항체 및 이의 용도
TIEFENTHALER GEORG, CARPY GUTIERREZ CIRLOS ALEJANDRO, HOFER THOMAS, MAJETY MEHER, HAGE CARINA, KIRCHNER SILKE, WEINDL THOMAS, NEUMANN CHRISTIANE, SPICK CHRISTIAN, MOESSNER EKKEHARD, BUJOTZEK ALEXANDER, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 17.08.2023
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Year of Publication 17.08.2023
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CD3 및 CD19에 결합하는 항체
TROCHANOWSKA HALINA, KLEIN CHRISTIAN, GONZALEZ NICOLINI MARIA VALERIA, UMANA PABLO, RICHTER WOLFGANG, KNAUPP ALEXANDER, WALDHAUER INJA, HOSSE RALF, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 22.02.2023
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Year of Publication 22.02.2023
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