Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome
Santiago-Fernández, Olaya, Osorio, Fernando G., Quesada, Víctor, Rodríguez, Francisco, Basso, Sammy, Maeso, Daniel, Rolas, Loïc, Barkaway, Anna, Nourshargh, Sussan, Folgueras, Alicia R., Freije, José M. P., López-Otín, Carlos
Published in Nature medicine (01.03.2019)
Published in Nature medicine (01.03.2019)
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Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
Bárcena, Clea, Valdés-Mas, Rafael, Mayoral, Pablo, Garabaya, Cecilia, Durand, Sylvère, Rodríguez, Francisco, Fernández-García, María Teresa, Salazar, Nuria, Nogacka, Alicja M., Garatachea, Nuria, Bossut, Noélie, Aprahamian, Fanny, Lucia, Alejandro, Kroemer, Guido, Freije, José M. P., Quirós, Pedro M., López-Otín, Carlos
Published in Nature Medicine (01.08.2019)
Published in Nature Medicine (01.08.2019)
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Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome
Puente, Xose S., Quesada, Victor, Osorio, Fernando G., Cabanillas, Rubén, Cadiñanos, Juan, Fraile, Julia M., Ordóñez, Gonzalo R., Puente, Diana A., Gutiérrez-Fernández, Ana, Fanjul-Fernández, Miriam, Lévy, Nicolas, Freije, José M.P., López-Otín, Carlos
Published in American journal of human genetics (13.05.2011)
Published in American journal of human genetics (13.05.2011)
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USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
Campos-Iglesias, Diana, Fraile, Julia M., Bretones, Gabriel, Montero, Alejandro A., Bonzon-Kulichenko, Elena, Vázquez, Jesús, López-Otín, Carlos, Freije, José M. P.
Published in Cell death & disease (26.01.2023)
Published in Cell death & disease (26.01.2023)
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NF-κB activation impairs somatic cell reprogramming in ageing
Soria-Valles, Clara, Osorio, Fernando G., Gutiérrez-Fernández, Ana, De Los Angeles, Alejandro, Bueno, Clara, Menéndez, Pablo, Martín-Subero, José I., Daley, George Q., Freije, José M. P., López-Otín, Carlos
Published in Nature cell biology (01.08.2015)
Published in Nature cell biology (01.08.2015)
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Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53
Ugalde, Alejandro P, Ramsay, Andrew J, de la Rosa, Jorge, Varela, Ignacio, Mariño, Guillermo, Cadiñanos, Juan, Lu, Jun, Freije, José MP, López-Otín, Carlos
Published in The EMBO journal (01.06.2011)
Published in The EMBO journal (01.06.2011)
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Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype
Lee, Su-Jin, Jung, Youn-Sang, Yoon, Min-Ho, Kang, So-Mi, Oh, Ah-Young, Lee, Jee-Hyun, Jun, So-Young, Woo, Tae-Gyun, Chun, Ho-Young, Kim, Sang Kyum, Chung, Kyu Jin, Lee, Ho-Young, Lee, Kyeong, Jin, Guanghai, Na, Min-Kyun, Ha, Nam Chul, Bárcena, Clea, Freije, José M P, López-Otín, Carlos, Song, Gyu Yong, Park, Bum-Joon
Published in The Journal of clinical investigation (01.10.2016)
Published in The Journal of clinical investigation (01.10.2016)
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Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
Mariño, Guillermo, Ugalde, Alejandro P., Fernández, Álvaro F., Osorio, Fernando G., Fueyo, Antonio, Freije, José M. P., López-Otín, Carlos
Published in Proceedings of the National Academy of Sciences - PNAS (14.09.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (14.09.2010)
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Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice
Fraile, Julia M., Campos-Iglesias, Diana, Rodríguez, Francisco, Astudillo, Aurora, Vilarrasa-Blasi, Roser, Verdaguer-Dot, Nuria, Prado, Miguel A., Paulo, Joao A., Gygi, Steven P., Martín-Subero, José I., Freije, José M.P., López-Otín, Carlos
Published in The Journal of biological chemistry (09.02.2018)
Published in The Journal of biological chemistry (09.02.2018)
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USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer
Fraile, Julia M., Manchado, Eusebio, Lujambio, Amaia, Quesada, Víctor, Campos-Iglesias, Diana, Webb, Thomas R., Lowe, Scott W., López-Otín, Carlos, Freije, José M.P.
Published in The Journal of biological chemistry (10.03.2017)
Published in The Journal of biological chemistry (10.03.2017)
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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
Varela, Ignacio, Osorio, Fernando G, Cobo, Juan, Suárez, María F, Freije, José M P, López-Otín, Carlos, Pereira, Sandrine, Cadiñanos, Juan, Ugalde, Alejandro P, de Carlos, Félix, Navarro, Claire L, Foray, Nicolas, Cau, Pierre, Lévy, Nicolas
Published in Nature Medicine (01.07.2008)
Published in Nature Medicine (01.07.2008)
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A conserved splicing mechanism of the LMNA gene controls premature aging
Lopez-Mejia, Isabel C., Vautrot, Valentin, De Toledo, Marion, Behm-Ansmant, Isabelle, Bourgeois, Cyril F., Navarro, Claire L., Osorio, Fernando G., Freije, José M. P., Stévenin, James, De Sandre-Giovannoli, Annachiara, Lopez-Otin, Carlos, Lévy, Nicolas, Branlant, Christiane, Tazi, Jamal
Published in Human molecular genetics (01.12.2011)
Published in Human molecular genetics (01.12.2011)
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Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
Espada, Jesús, Varela, Ignacio, Flores, Ignacio, Ugalde, Alejandro P, Cadiñanos, Juan, Pendás, Alberto M, Stewart, Colin L, Tryggvason, Karl, Blasco, María A, Freije, José M.P, López-Otín, Carlos
Published in The Journal of cell biology (07.04.2008)
Published in The Journal of cell biology (07.04.2008)
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Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling
Osorio, Fernando G, Soria-Valles, Clara, Santiago-Fernández, Olaya, Bernal, Teresa, Mittelbrunn, María, Colado, Enrique, Rodríguez, Francisco, Bonzon-Kulichenko, Elena, Vázquez, Jesús, Porta-de-la-Riva, Montserrat, Cerón, Julián, Fueyo, Antonio, Li, Juan, Green, Anthony R, Freije, José M P, López-Otín, Carlos
Published in Nature medicine (01.01.2016)
Published in Nature medicine (01.01.2016)
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Premature aging in mice activates a systemic metabolic response involving autophagy induction
Mariño, Guillermo, Ugalde, Alejandro P., Salvador-Montoliu, Natalia, Varela, Ignacio, Quirós, Pedro M., Cadiñanos, Juan, van der Pluijm, Ingrid, Freije, José M.P., López-Otín, Carlos
Published in Human molecular genetics (15.07.2008)
Published in Human molecular genetics (15.07.2008)
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Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses
Fanjul-Fernández, Miriam, Folgueras, Alicia R., Fueyo, Antonio, Balbín, Milagros, Suárez, María F., Fernández-García, M. Soledad, Shapiro, Steven D., Freije, José M.P., López-Otín, Carlos
Published in The Journal of biological chemistry (27.07.2018)
Published in The Journal of biological chemistry (27.07.2018)
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Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells
Garrido, Pablo, Osorio, Fernando G., Morán, Javier, Cabello, Estefanía, Alonso, Ana, Freije, José M.P., González, Celestino
Published in Journal of cellular physiology (01.01.2015)
Published in Journal of cellular physiology (01.01.2015)
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Splicing-directed therapy in a new mouse model of human accelerated aging
Osorio, Fernando G, Navarro, Claire L, Cadiñanos, Juan, López-Mejía, Isabel C, Quirós, Pedro M, Bartoli, Catherine, Rivera, José, Tazi, Jamal, Guzmán, Gabriela, Varela, Ignacio, Depetris, Danielle, de Carlos, Félix, Cobo, Juan, Andrés, Vicente, De Sandre-Giovannoli, Annachiara, Freije, José M P, Lévy, Nicolas, López-Otín, Carlos
Published in Science translational medicine (26.10.2011)
Published in Science translational medicine (26.10.2011)
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Protease Silencing to Explore the Molecular Mechanisms of Cancer and Aging
Fraile, Julia M, Campos-Iglesias, Diana, Freije, José M P
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2018)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2018)
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