Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention
Brings, Sebastian, Fleming, Thomas, Freichel, Marc, Muckenthaler, Martina U, Herzig, Stephan, Nawroth, Peter P
Published in International journal of molecular sciences (05.05.2017)
Published in International journal of molecular sciences (05.05.2017)
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Journal Article
Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells
Morgenstern, Jakob, Fleming, Thomas, Schumacher, Dagmar, Eckstein, Volker, Freichel, Marc, Herzig, Stephan, Nawroth, Peter
Published in The Journal of biological chemistry (24.02.2017)
Published in The Journal of biological chemistry (24.02.2017)
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Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis
Rosenkranz, Sina C, Shaposhnykov, Artem A, Träger, Simone, Engler, Jan Broder, Witte, Maarten E, Roth, Vanessa, Vieira, Vanessa, Paauw, Nanne, Bauer, Simone, Schwencke-Westphal, Celina, Schubert, Charlotte, Bal, Lukas Can, Schattling, Benjamin, Pless, Ole, van Horssen, Jack, Freichel, Marc, Friese, Manuel A
Published in eLife (10.02.2021)
Published in eLife (10.02.2021)
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TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses
Schwarz, Yvonne, Oleinikov, Katharina, Schindeldecker, Barbara, Wyatt, Amanda, Weißgerber, Petra, Flockerzi, Veit, Boehm, Ulrich, Freichel, Marc, Bruns, Dieter
Published in PLoS biology (01.09.2019)
Published in PLoS biology (01.09.2019)
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Journal Article
Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory
Bröker‐Lai, Jenny, Kollewe, Astrid, Schindeldecker, Barbara, Pohle, Jörg, Nguyen Chi, Vivan, Mathar, Ilka, Guzman, Raul, Schwarz, Yvonne, Lai, Alan, Weißgerber, Petra, Schwegler, Herbert, Dietrich, Alexander, Both, Martin, Sprengel, Rolf, Draguhn, Andreas, Köhr, Georg, Fakler, Bernd, Flockerzi, Veit, Bruns, Dieter, Freichel, Marc
Published in The EMBO journal (15.09.2017)
Published in The EMBO journal (15.09.2017)
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Boosting targeted genome editing using the hei-tag
Thumberger, Thomas, Tavhelidse-Suck, Tinatini, Gutierrez-Triana, Jose Arturo, Cornean, Alex, Medert, Rebekka, Welz, Bettina, Freichel, Marc, Wittbrodt, Joachim
Published in eLife (25.03.2022)
Published in eLife (25.03.2022)
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Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
Schumacher, Dagmar, Morgenstern, Jakob, Oguchi, Yoko, Volk, Nadine, Kopf, Stefan, Groener, Jan Benedikt, Nawroth, Peter Paul, Fleming, Thomas, Freichel, Marc
Published in Molecular metabolism (Germany) (01.12.2018)
Published in Molecular metabolism (Germany) (01.12.2018)
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Knock-Out of IKKepsilon Ameliorates Atherosclerosis and Fatty Liver Disease by Alterations of Lipid Metabolism in the PCSK9 Model in Mice
Weiss, Ulrike, Mungo, Eleonora, Haß, Michelle, Benning, Denis, Gurke, Robert, Hahnefeld, Lisa, Dorochow, Erika, Schlaudraff, Jessica, Schmid, Tobias, Kuntschar, Silvia, Meyer, Sofie, Medert, Rebekka, Freichel, Marc, Geisslinger, Gerd, Niederberger, Ellen
Published in International journal of molecular sciences (01.10.2024)
Published in International journal of molecular sciences (01.10.2024)
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Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis
Maeder, Christina, Speer, Thimoteus, Wirth, Angela, Boeckel, Jes-Niels, Fatima, Sameen, Shahzad, Khurrum, Freichel, Marc, Laufs, Ulrich, Gaul, Susanne
Published in Frontiers in immunology (28.08.2023)
Published in Frontiers in immunology (28.08.2023)
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Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart
Medert, Rebekka, Jungmann, Andreas, Hildebrand, Staffan, Busch, Martin, Grimm, Dirk, Flockerzi, Veit, Müller, Oliver J., Most, Patrick, Schumacher, Dagmar, Freichel, Marc
Published in Pflügers Archiv (01.03.2021)
Published in Pflügers Archiv (01.03.2021)
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Journal Article
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo
Tsvilovskyy, Volodymyr V, Zholos, Alexander V, Aberle, Thomas, Philipp, Stephan E, Dietrich, Alexander, Zhu, Michael X, Birnbaumer, Lutz, Freichel, Marc, Flockerzi, Veit
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2009)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2009)
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Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms
Phelan, Kevin D, Shwe, U Thaung, Abramowitz, Joel, Wu, Hong, Rhee, Sung W, Howell, Matthew D, Gottschall, Paul E, Freichel, Marc, Flockerzi, Veit, Birnbaumer, Lutz, Zheng, Fang
Published in Molecular pharmacology (01.02.2013)
Published in Molecular pharmacology (01.02.2013)
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De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury
Ivanova, Svetlana, Freichel, Marc, Tsymbalyuk, Orest, Ivanov, Alexander, Gerzanich, Volodymyr, Nilius, Bernd, Simard, J Marc, Vennekens, Rudi, Flockerzi, Veit, Geng, Zhihua, Chen, Zheng, Woo, S Kyoon
Published in Nature medicine (01.02.2009)
Published in Nature medicine (01.02.2009)
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The Ca2+ Sensor Stromal Interaction Molecule 1 (STIM1) Is Necessary and Sufficient for the Store-Operated Ca2+ Entry Function of Transient Receptor Potential Canonical (TRPC) 1 and 4 Channels in Endothelial Cells
Sundivakkam, Premanand C, Freichel, Marc, Singh, Vandana, Yuan, Joseph P, Vogel, Stephen M, Flockerzi, Veit, Malik, Asrar B, Tiruppathi, Chinnaswamy
Published in Molecular pharmacology (01.04.2012)
Published in Molecular pharmacology (01.04.2012)
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MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP
Krukenberg, Sarah, Möckl, Franziska, Weiß, Mariella, Dekiert, Patrick, Hofmann, Melanie, Gerlach, Fynn, Winterberg, Kai J., Kovacevic, Dejan, Khansahib, Imrankhan, Troost, Berit, Hinrichs, Macarena, Granato, Viviana, Nawrocki, Mikolaj, Hub, Tobis, Tsvilovskyy, Volodymyr, Medert, Rebekka, Woelk, Lena-Marie, Förster, Fritz, Li, Huan, Werner, René, Altfeld, Marcus, Huber, Samuel, Clarke, Oliver Biggs, Freichel, Marc, Diercks, Björn-Philipp, Meier, Chris, Guse, Andreas H.
Published in Nature communications (13.09.2024)
Published in Nature communications (13.09.2024)
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NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells
Stroh, Olga, Freichel, Marc, Kretz, Oliver, Birnbaumer, Lutz, Hartmann, Jana, Egger, Veronica
Published in The Journal of neuroscience (25.04.2012)
Published in The Journal of neuroscience (25.04.2012)
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Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice
Weissmann, Norbert, Sydykov, Akylbek, Kalwa, Hermann, Storch, Ursula, Fuchs, Beate, Mederos y Schnitzler, Michael, Brandes, Ralf P., Grimminger, Friedrich, Meissner, Marcel, Freichel, Marc, Offermanns, Stefan, Veit, Florian, Pak, Oleg, Krause, Karl-Heinz, Schermuly, Ralph T., Brewer, Alison C, Schmidt, Harald H.H.W., Seeger, Werner, Shah, Ajay M., Gudermann, Thomas, Ghofrani, Hossein A., Dietrich, Alexander
Published in Nature communications (31.01.2012)
Published in Nature communications (31.01.2012)
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Analysis of Mrgprb2 Receptor-Evoked Ca2+ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice
Tsvilovskyy, Volodymyr, Solis-Lopez, Alejandra, Almering, Julia, Richter, Christin, Birnbaumer, Lutz, Dietrich, Alexander, Freichel, Marc
Published in Frontiers in immunology (08.04.2020)
Published in Frontiers in immunology (08.04.2020)
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