Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition
Eggink, Florine A., Van Gool, Inge C., Leary, Alexandra, Pollock, Pamela M., Crosbie, Emma J., Mileshkin, Linda, Jordanova, Ekaterina S., Adam, Julien, Freeman-Mills, Luke, Church, David N., Creutzberg, Carien L., De Bruyn, Marco, Nijman, Hans W., Bosse, Tjalling
Published in Oncoimmunology (01.02.2017)
Published in Oncoimmunology (01.02.2017)
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Journal Article
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer
van Gool, Inge C, Eggink, Florine A, Freeman-Mills, Luke, Stelloo, Ellen, Marchi, Emanuele, de Bruyn, Marco, Palles, Claire, Nout, Remi A, de Kroon, Cor D, Osse, Elisabeth M, Klenerman, Paul, Creutzberg, Carien L, Tomlinson, Ian Pm, Smit, Vincent Thbm, Nijman, Hans W, Bosse, Tjalling, Church, David N
Published in Clinical cancer research (15.07.2015)
Published in Clinical cancer research (15.07.2015)
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Journal Article
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
Davis, Hayley, Irshad, Shazia, Bansal, Mukesh, Rafferty, Hannah, Boitsova, Tatjana, Bardella, Chiara, Jaeger, Emma, Lewis, Annabelle, Freeman-Mills, Luke, Giner, Francesc C, Rodenas-Cuadrado, Pedro, Mallappa, Sreelakshmi, Clark, Susan, Thomas, Huw, Jeffery, Rosemary, Poulsom, Richard, Rodriguez-Justo, Manuel, Novelli, Marco, Chetty, Runjan, Silver, Andrew, Sansom, Owen J, Greten, Florian R, Wang, Lai Mun, East, James E, Tomlinson, Ian, Leedham, Simon J
Published in Nature medicine (01.01.2015)
Published in Nature medicine (01.01.2015)
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Journal Article
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
Domingo, Enric, Freeman-Mills, Luke, Rayner, Emily, Glaire, Mark, Briggs, Sarah, Vermeulen, Louis, Fessler, Evelyn, Medema, Jan Paul, Boot, Arnoud, Morreau, Hans, van Wezel, Tom, Liefers, Gerrit-Jan, Lothe, Ragnhild A, Danielsen, Stine A, Sveen, Anita, Nesbakken, Arild, Zlobec, Inti, Lugli, Alessandro, Koelzer, Viktor H, Berger, Martin D, Castellví-Bel, Sergi, Muñoz, Jenifer, de Bruyn, Marco, Nijman, Hans W, Novelli, Marco, Lawson, Kay, Oukrif, Dahmane, Frangou, Eleni, Dutton, Peter, Tejpar, Sabine, Delorenzi, Mauro, Kerr, Rachel, Kerr, David, Tomlinson, Ian, Church, David N
Published in The lancet. Gastroenterology & hepatology (01.11.2016)
Published in The lancet. Gastroenterology & hepatology (01.11.2016)
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Journal Article
A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding
Lewis, Annabelle, Freeman-Mills, Luke, de la Calle-Mustienes, Elisa, Giráldez-Pérez, Rosa María, Davis, Hayley, Jaeger, Emma, Becker, Martin, Hubner, Nina C., Nguyen, Luan N., Zeron-Medina, Jorge, Bond, Gareth, Stunnenberg, Hendrik G., Carvajal, Jaime J., Gomez-Skarmeta, Jose Luis, Leedham, Simon, Tomlinson, Ian
Published in Cell reports (Cambridge) (21.08.2014)
Published in Cell reports (Cambridge) (21.08.2014)
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Journal Article
Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism
Aughey, Gabriel N, Grice, Stuart J, Shen, Qing-Ji, Xu, Yichi, Chang, Chia-Chun, Azzam, Ghows, Wang, Pei-Yu, Freeman-Mills, Luke, Pai, Li-Mei, Sung, Li-Ying, Yan, Jun, Liu, Ji-Long
Published in Biology open (15.11.2014)
Published in Biology open (15.11.2014)
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Journal Article
Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis
Bardella, Chiara, Al-Dalahmah, Osama, Krell, Daniel, Brazauskas, Pijus, Al-Qahtani, Khalid, Tomkova, Marketa, Adam, Julie, Serres, Sébastien, Lockstone, Helen, Freeman-Mills, Luke, Pfeffer, Inga, Sibson, Nicola, Goldin, Robert, Schuster-Böeckler, Benjamin, Pollard, Patrick J., Soga, Tomoyoshi, McCullagh, James S., Schofield, Christopher J., Mulholland, Paul, Ansorge, Olaf, Kriaucionis, Skirmantas, Ratcliffe, Peter J., Szele, Francis G., Tomlinson, Ian
Published in Cancer cell (10.10.2016)
Published in Cancer cell (10.10.2016)
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Journal Article
EXABS-156-CML Beyond TKI Therapy in CML
Freeman-Mills, Luke, Copland, Mhairi
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Journal Article
COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study
Lee, Lennard YW, Cazier, Jean-Baptiste, Angelis, Vasileios, Arnold, Roland, Bisht, Vartika, Campton, Naomi A, Chackathayil, Julia, Cheng, Vinton WT, Curley, Helen M, Fittall, Matthew W, Freeman-Mills, Luke, Gennatas, Spyridon, Goel, Anshita, Hartley, Simon, Hughes, Daniel J, Kerr, David, Lee, Alvin JX, Lee, Rebecca J, McGrath, Sophie E, Middleton, Christopher P, Murugaesu, Nirupa, Newsom-Davis, Thomas, Okines, Alicia FC, Olsson-Brown, Anna C, Palles, Claire, Pan, Yi, Pettengell, Ruth, Powles, Thomas, Protheroe, Emily A, Purshouse, Karin, Sharma-Oates, Archana, Sivakumar, Shivan, Smith, Ashley J, Starkey, Thomas, Turnbull, Chris D, Várnai, Csilla, Yousaf, Nadia, Kerr, Rachel, Middleton, Gary
Published in The Lancet (20.06.2020)
Published in The Lancet (20.06.2020)
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Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis
Bardella, C., Al-Dalahmah, O., Krell, D., Brazauskas, P., Al-Qahtani, K., Tomkova, M., Adam, J., Serres, S., Lockstone, H., Freeman-Mills, L., Pfeffer, I., Sibson, N., Goldin, R., Schuster-Boeckler, B., Pollard, Patrick, Soga, T., McCullagh, J. S., Schofield, C. J., Mulholland, P., Ansorge, O., Kriaucionis, S., Ratcliffe, P. J., Szele, F. G., Tomlinson, I.
Published in Cancer cell (10.10.2016)
Published in Cancer cell (10.10.2016)
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A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS
Rosmarin, Dan, Palles, Claire, Pagnamenta, Alistair, Kaur, Kulvinder, Pita, Guillermo, Martin, Miguel, Domingo, Enric, Jones, Angela, Howarth, Kimberley, Freeman-Mills, Luke, Johnstone, Elaine, Wang, Haitao, Love, Sharon, Scudder, Claire, Julier, Patrick, Fernández-Rozadilla, Ceres, Ruiz-Ponte, Clara, Carracedo, Angel, Castellvi-Bel, Sergi, Castells, Antoni, Gonzalez-Neira, Anna, Taylor, Jenny, Kerr, Rachel, Kerr, David, Tomlinson, Ian
Published in Gut (01.01.2015)
Published in Gut (01.01.2015)
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Journal Article
Immune checkpoint blockade: releasing the breaks or a protective barrier to COVID-19 severe acute respiratory syndrome?
Pickles, Oliver J., Lee, Lennard Y. W., Starkey, Thomas, Freeman-Mills, Luke, Olsson-Brown, Anna, Cheng, Vinton, Hughes, Daniel J., Lee, Alvin, Purshouse, Karin, Middleton, Gary
Published in British journal of cancer (01.09.2020)
Published in British journal of cancer (01.09.2020)
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Metastatic disease representation: An analysis of 148 paired colorectal cancer lymph node metastatic tumour deposits
Lee, Lennard YW, Anderson, Joanna, Arnold, Roland, Freeman Mills, Luke, Mun Wang, Lai, Tomlinson, Ian
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article
Expression of Idh1 R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis
Bardella, Chiara, Al-Dalahmah, Osama, Krell, Daniel, Brazauskas, Pijus, Al-Qahtani, Khalid, Tomkova, Marketa, Adam, Julie, Serres, Sébastien, Lockstone, Helen, Freeman-Mills, Luke, Pfeffer, Inga, Sibson, Nicola, Goldin, Robert, Schuster-Böeckler, Benjamin, Pollard, Patrick J, Soga, Tomoyoshi, McCullagh, James S, Schofield, Christopher J, Mulholland, Paul, Ansorge, Olaf, Kriaucionis, Skirmantas, Ratcliffe, Peter J, Szele, Francis G, Tomlinson, Ian
Published in Cancer cell (10.10.2016)
Published in Cancer cell (10.10.2016)
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Journal Article
POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer
van Gool, Inge C, Eggink, Florine A, Freeman-Mills, Luke, Stelloo, Ellen, Marchi, Emanuele, de Bruyn, Marco, Palles, Claire, Nout, Remi A, de Kroon, Cor D, Osse, Elisabeth M, Klenerman, Paul, Creutzberg, Carien L, Tomlinson, Ian PM, Smit, Vincent THBM, Nijman, Hans W, Bosse, Tjalling, Church, David N
Published in Clinical cancer research (15.04.2015)
Published in Clinical cancer research (15.04.2015)
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Journal Article
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside of the crypt base stem cell niche
Davis, Hayley, Irshad, Shazia, Bansal, Mukesh, Rafferty, Hannah, Boitsova, Tatjana, Bardella, Chiara, Jaeger, Emma, Lewis, Annabelle, Freeman-Mills, Luke, Giner, Francesc Castro, Rodenas-Cuadrado, Pedro, Mallappa, Sreelakshmi, Clark, Susan, Thomas, Huw, Jeffery, Rosemary, Poulsom, Richard, Rodriguez-Justo, Manuel, Novelli, Marco, Chetty, Runjan, Silver, Andrew, Sansom, Owen James, Greten, Florian R, Wang, Lai Mun, East, James Edward, Tomlinson, Ian, Leedham, Simon John
Published in Nature medicine (01.12.2014)
Published in Nature medicine (01.12.2014)
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Journal Article
A CRISPR Knockout Screen Identifies Foxf1 as a Suppressor of Colorectal Cancer Metastasis That Acts Through Reduced mTOR Signalling
Lee, Lennard Yw, Woolley, Connor, Starkey, Thomas, Freeman-Mills, Luke, Bassett, Andrew, Franchini, Fanny, Wang, Lai Mun, Lewis, Annabelle Jane, Arnold, Roland, Tomlinson, Ian
Published in bioRxiv (18.04.2019)
Published in bioRxiv (18.04.2019)
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