Search Results - "Freeman, Katie T." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint

Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint

by Ghilardi, Joseph R., Freeman, Katie T., Jimenez-Andrade, Juan M., Coughlin, Kathleen A., Kaczmarska, Magdalena J., Castaneda-Corral, Gabriela, Bloom, Aaron P., Kuskowski, Michael A., Mantyh, Patrick W.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2012)

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Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain

Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain

by Jimenez-Andrade, Juan M, Bloom, Aaron P, Stake, James I, Mantyh, William G, Taylor, Reid N, Freeman, Katie T, Ghilardi, Joseph R, Kuskowski, Michael A, Mantyh, Patrick W
Published in The Journal of neuroscience (03.11.2010)

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The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

by Ericson, Mark D, Freeman, Katie T, LaVoi, Travis M, Donow, Haley M, Santos, Radleigh G, Giulianotti, Marc A, Pinilla, Clemencia, Houghten, Richard A, Haskell-Luevano, Carrie
Published in International journal of molecular sciences (14.06.2023)

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Breast Cancer-Induced Bone Remodeling, Skeletal Pain, and Sprouting of Sensory Nerve Fibers

Breast Cancer-Induced Bone Remodeling, Skeletal Pain, and Sprouting of Sensory Nerve Fibers

by Bloom, Aaron P, Jimenez-Andrade, Juan M, Taylor, Reid N, Castañeda-Corral, Gabriela, Kaczmarska, Magdalena J, Freeman, Katie T, Coughlin, Kathleen A, Ghilardi, Joseph R, Kuskowski, Michael A, Mantyh, Patrick W
Published in The journal of pain (01.06.2011)

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Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

by Schlasner, Katherine N., Ericson, Mark D., Doering, Skye R., Freeman, Katie T., Weinrich, Mary, Haskell-Luevano, Carrie
Published in Molecules (Basel, Switzerland) (13.04.2019)

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Administration of a Tropomyosin Receptor Kinase Inhibitor Attenuates Sarcoma-Induced Nerve Sprouting, Neuroma Formation and Bone Cancer Pain

Administration of a Tropomyosin Receptor Kinase Inhibitor Attenuates Sarcoma-Induced Nerve Sprouting, Neuroma Formation and Bone Cancer Pain

by Ghilardi, Joseph R, Freeman, Katie T, Jimenez-Andrade, Juan M, Mantyh, William G, Bloom, Aaron P, Kuskowski, Michael A, Mantyh, Patrick W
Published in Molecular pain (07.12.2010)

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$Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture$

Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture

by Jimenez-Andrade, Juan M., Martin, Carl D., Koewler, Nathan J., Freeman, Katie T., Sullivan, Lucy J., Halvorson, Kyle G., Barthold, Christina M., Peters, Christopher M., Buus, Ryan J., Ghilardi, Joseph R., Lewis, Jack L., Kuskowski, Michael A., Mantyh, Patrick W.
Published in Pain (Amsterdam) (15.12.2007)

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Effects of a Monoclonal Antibody Raised Against Nerve Growth Factor on Skeletal Pain and Bone Healing After Fracture of the C57BL/6J Mouse Femur

Effects of a Monoclonal Antibody Raised Against Nerve Growth Factor on Skeletal Pain and Bone Healing After Fracture of the C57BL/6J Mouse Femur

by Koewler, Nathan J, Freeman, Katie T, Buus, Ryan J, Herrera, Monica B, Jimenez‐Andrade, Juan M, Ghilardi, Joseph R, Peters, Christopher M, Sullivan, Lucy J, Kuskowski, Michael A, Lewis, Jack L, Mantyh, Patrick W
Published in Journal of bone and mineral research (01.11.2007)

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Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes

Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes

by Koikov, Leonid, Starner, Renny J., Swope, Viki B., Upadhyay, Parth, Hashimoto, Yuki, Freeman, Katie T., Knittel, James J., Haskell-Luevano, Carrie, Abdel-Malek, Zalfa A.
Published in Journal of investigative dermatology (01.07.2021)

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Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2′)-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2′)-Arg-NH2]

Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2′)-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2′)-Arg-NH2]

by Ericson, Mark D., Tran, Linh T., Mathre, Sarah S., Freeman, Katie T., Holdaway, Kelsey, John, Kristen, Lunzer, Mary M., Bouchard, Jacob L., Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (22.06.2023)

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Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe‑dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists

Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe‑dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists

by Fleming, Katlyn A, Freeman, Katie T, Ericson, Mark D, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (13.09.2018)

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An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers

An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers

by Lensing, Cody J, Freeman, Katie T, Schnell, Sathya M, Adank, Danielle N, Speth, Robert C, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (14.04.2016)

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Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β‑Arrestin 2 Recruitment) Within the Melanocortin Receptors

Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β‑Arrestin 2 Recruitment) Within the Melanocortin Receptors

by Lensing, Cody J, Freeman, Katie T, Schnell, Sathya M, Speth, Robert C, Zarth, Adam T, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (10.01.2019)

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Structure–Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin‑4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin‑5 Receptor

Structure–Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin‑4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin‑5 Receptor

by Ericson, Mark D, Freeman, Katie T, Schnell, Sathya M, Fleming, Katlyn A, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (12.10.2017)

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A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist

A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist

by Ericson, Mark D., Schnell, Sathya M., Freeman, Katie T., Haskell-Luevano, Carrie
Published in Bioorganic & medicinal chemistry letters (15.11.2015)

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Peptoid NPhe4 in AGRP-Based c[Pro1‑Arg2‑Phe3‑Phe4‑Xxx5‑Ala6‑Phe7‑DPro8] Scaffolds Maintain Mouse MC4R Antagonist Potency

Peptoid NPhe4 in AGRP-Based c[Pro1‑Arg2‑Phe3‑Phe4‑Xxx5‑Ala6‑Phe7‑DPro8] Scaffolds Maintain Mouse MC4R Antagonist Potency

by Ericson, Mark D, Freeman, Katie T, Haskell-Luevano, Carrie
Published in ACS medicinal chemistry letters (08.10.2020)

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Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe‑dPro] Decreases Melanocortin‑4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin‑5 Receptor Antagonists

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe‑dPro] Decreases Melanocortin‑4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin‑5 Receptor Antagonists

by Koerperich, Zoe M, Ericson, Mark D, Freeman, Katie T, Speth, Robert C, Pogozheva, Irina D, Mosberg, Henry I, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (12.03.2020)

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A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands

A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands

by Ericson, Mark D, Freeman, Katie T, Schnell, Sathya M, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (26.01.2017)

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Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin‑4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist

Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin‑4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist

by Ericson, Mark D, Doering, Skye R, Larson, Courtney M, Freeman, Katie T, LaVoi, Travis M, Donow, Haley M, Santos, Radleigh G, Cho, Rachel H, Koerperich, Zoe M, Giulianotti, Marc A, Pinilla, Clemencia, Houghten, Richard A, Haskell-Luevano, Carrie
Published in Journal of medicinal chemistry (14.10.2021)

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Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist

Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist

by Ericson, Mark D., Shaikh, Romessa, Larson, Courtney M., Freeman, Katie T., Haskell-Luevano, Carrie
Published in ACS medicinal chemistry letters (14.01.2021)

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