Optimizing oncolytic virotherapy in cancer treatment
Harrington, Kevin, Freeman, Daniel J., Kelly, Beth, Harper, James, Soria, Jean-Charles
Published in Nature reviews. Drug discovery (01.09.2019)
Published in Nature reviews. Drug discovery (01.09.2019)
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Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
AMADO, Rafael G, WOLF, Michael, PATTERSON, Scott D, CHANG, David D, PEETERS, Marc, VAN CUTSEM, Eric, SIENA, Salvatore, FREEMAN, Daniel J, JUAN, Todd, SIKORSKI, Robert, SUGGS, Sid, RADINSKY, Robert
Published in Journal of clinical oncology (01.04.2008)
Published in Journal of clinical oncology (01.04.2008)
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Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer
Freeman, Daniel J, McDorman, Kevin, Ogbagabriel, Selam, Kozlosky, Carl, Yang, Bing-Bing, Doshi, Sameer, Perez-Ruxio, Juan Jose, Fanslow, William, Starnes, Charlie, Radinsky, Robert
Published in Molecular cancer (25.07.2012)
Published in Molecular cancer (25.07.2012)
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Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer
Mendell, Jeanne, Freeman, Daniel J., Feng, Wenqin, Hettmann, Thore, Schneider, Matthias, Blum, Sabine, Ruhe, Jens, Bange, Johannes, Nakamaru, Kenji, Chen, Shuquan, Tsuchihashi, Zenta, von Pawel, Joachim, Copigneaux, Catherine, Beckman, Robert A.
Published in EBioMedicine (01.03.2015)
Published in EBioMedicine (01.03.2015)
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PTEN Regulates Mdm2 Expression through the P1 Promoter
Chang, Chun-Ju, Freeman, Daniel J, Wu, Hong
Published in The Journal of biological chemistry (09.07.2004)
Published in The Journal of biological chemistry (09.07.2004)
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Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor
Freeman, Daniel J, Bush, Tammy, Ogbagabriel, Selam, Belmontes, Brian, Juan, Todd, Plewa, Cherylene, Van, Gwyneth, Johnson, Carol, Radinsky, Robert
Published in Molecular cancer therapeutics (01.06.2009)
Published in Molecular cancer therapeutics (01.06.2009)
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A comparability study of 5 commercial KRAS tests
Oliner, Kelly, Juan, Todd, Suggs, Sid, Wolf, Michael, Sarosi, Ildiko, Freeman, Daniel J, Gyuris, Tibor, Baron, Will, Bakker, Andreas, Parker, Alex, Patterson, Scott D
Published in Diagnostic pathology (16.04.2010)
Published in Diagnostic pathology (16.04.2010)
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Augmentation of Radiation Response by Panitumumab in Models of Upper Aerodigestive Tract Cancer
Kruser, Tim J., M.D, Armstrong, Eric A., M.S, Ghia, Amol J., M.D, Huang, Shyhmin, Ph.D, Wheeler, Deric L., Ph.D, Radinsky, Robert, Ph.D, Freeman, Daniel J., Ph.D, Harari, Paul M., M.D
Published in International journal of radiation oncology, biology, physics (01.10.2008)
Published in International journal of radiation oncology, biology, physics (01.10.2008)
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Journal Article
Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
Amado, Rafael G, Wolf, Michael, Peeters, Marc, Van Cutsem, Eric, Siena, Salvatore, Freeman, Daniel J, Juan, Todd, Sikorski, Robert, Suggs, Sid, Radinsky, Robert, Patterson, Scott D, Chang, David D
Published in Journal of clinical oncology (20.06.2023)
Published in Journal of clinical oncology (20.06.2023)
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Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1 + Activated T Cells
Dovedi, Simon J, Elder, Matthew J, Yang, Chunning, Sitnikova, Suzanne I, Irving, Lorraine, Hansen, Anna, Hair, James, Jones, Des C, Hasani, Sumati, Wang, Bo, Im, Seock-Ah, Tran, Ben, Subramaniam, Deepa S, Gainer, Shelby D, Vashisht, Kapil, Lewis, Arthur, Jin, Xiaofang, Kentner, Stacy, Mulgrew, Kathy, Wang, Yaya, Overstreet, Michael G, Dodgson, James, Wu, Yanli, Palazon, Asis, Morrow, Michelle, Rainey, Godfrey J, Browne, Gareth J, Neal, Frances, Murray, Thomas V, Toloczko, Aleksandra D, Dall'Acqua, William, Achour, Ikbel, Freeman, Daniel J, Wilkinson, Robert W, Mazor, Yariv
Published in Cancer discovery (01.05.2021)
Published in Cancer discovery (01.05.2021)
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Azole-based inhibitors of AKT/PKB for the treatment of cancer
Zeng, Qingping, Allen, John G., Bourbeau, Matthew P., Wang, Xianghong, Yao, Guomin, Tadesse, Seifu, Rider, James T., Yuan, Chester C., Hong, Fang-Tsao, Lee, Matthew R., Zhang, Shiwen, Lofgren, Julie A., Freeman, Daniel J., Yang, Suijin, Li, Chun, Tominey, Elizabeth, Huang, Xin, Hoffman, Douglas, Yamane, Harvey K., Fotsch, Christopher, Dominguez, Celia, Hungate, Randall, Zhang, Xiaoling
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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A Phase 2 Randomized Trial of Paclitaxel and Carboplatin with or without Panitumumab for First-Line Treatment of Advanced Non–Small-Cell Lung Cancer
Crawford, Jeffrey, Swanson, Paul, Schwarzenberger, Paul, Sandler, Alan, Prager, Diane, Zhang, Kathy, Freeman, Daniel J., Johnson, Carol W., Krishnan, Kartik, Johnson, David
Published in Journal of thoracic oncology (01.12.2013)
Published in Journal of thoracic oncology (01.12.2013)
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PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
Freeman, Daniel J., Li, Andrew G., Wei, Gang, Li, Heng-Hong, Kertesz, Nathalie, Lesche, Ralf, Whale, Andrew D., Martinez-Diaz, Hilda, Rozengurt, Nora, Cardiff, Robert D., Liu, Xuan, Wu, Hong
Published in Cancer cell (01.02.2003)
Published in Cancer cell (01.02.2003)
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Journal Article
Association of K- ras Mutational Status and Clinical Outcomes in Patients with Metastatic Colorectal Cancer Receiving Panitumumab Alone
Freeman, Daniel J, Juan, Todd, Reiner, Maureen, Hecht, J. Randolph, Meropol, Neal J, Berlin, Jordan, Mitchell, Edith, Sarosi, Ildiko, Radinsky, Robert, Amado, Rafael G
Published in Clinical colorectal cancer (01.05.2008)
Published in Clinical colorectal cancer (01.05.2008)
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Structure–Activity Relationships of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Investigations of Various 6,5-Heterocycles to Improve Metabolic Stability
Stec, Markian M, Andrews, Kristin L, Booker, Shon K, Caenepeel, Sean, Freeman, Daniel J, Jiang, Jian, Liao, Hongyu, McCarter, John, Mullady, Erin L, San Miguel, Tisha, Subramanian, Raju, Tamayo, Nuria, Wang, Ling, Yang, Kevin, Zalameda, Leeanne P, Zhang, Nancy, Hughes, Paul E, Norman, Mark H
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Journal Article
Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases
Smith, Adrian L, D’Angelo, Noel D, Bo, Yunxin Y, Booker, Shon K, Cee, Victor J, Herberich, Brad, Hong, Fang-Tsao, Jackson, Claire L. M, Lanman, Brian A, Liu, Longbin, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Tadesse, Seifu, Tamayo, Nuria A, Wurz, Ryan P, Yang, Kevin, Andrews, Kristin L, Whittington, Douglas A, McCarter, John D, Miguel, Tisha San, Zalameda, Leeanne, Jiang, Jian, Subramanian, Raju, Mullady, Erin L, Caenepeel, Sean, Freeman, Daniel J, Wang, Ling, Zhang, Nancy, Wu, Tian, Hughes, Paul E, Norman, Mark H
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Journal Article
Synthesis and structure–activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold
Wurz, Ryan P., Liu, Longbin, Yang, Kevin, Nishimura, Nobuko, Bo, Yunxin, Pettus, Liping H., Caenepeel, Sean, Freeman, Daniel J., McCarter, John D., Mullady, Erin L., Miguel, Tisha San, Wang, Ling, Zhang, Nancy, Andrews, Kristin L., Whittington, Douglas A., Jiang, Jian, Subramanian, Raju, Hughes, Paul E., Norman, Mark H.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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