Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase
Deschamps, Joshua D, Ogunsola, Abiola F, Jameson, J. Brian, Yasgar, Adam, Flitter, Becca A, Freedman, Cody J, Melvin, Jeffrey A, Nguyen, Jason V. M. H, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Bomberger, Jennifer M, Holman, Theodore R
Published in Biochemistry (Easton) (14.06.2016)
Published in Biochemistry (Easton) (14.06.2016)
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DHA 12‐LOX‐derived oxylipins regulate platelet activation and thrombus formation through a PKA‐dependent signaling pathway
Yamaguchi, Adriana, Stanger, Livia, Freedman, Cody J., Standley, Melissa, Hoang, Timothy, Adili, Reheman, Tsai, Wan‐Chen, van Hoorebeke, Christopher, Holman, Theodore R., Holinstat, Michael
Published in Journal of thrombosis and haemostasis (01.03.2021)
Published in Journal of thrombosis and haemostasis (01.03.2021)
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Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids
Yamaguchi, Adriana, Hoorebeke, Christopher, Tourdot, Benjamin E., Perry, Steven C., Lee, Grace, Rhoads, Nicole, Rickenberg, Andrew, Green, Abigail R., Sorrentino, James, Yeung, Jennifer, Freedman, J. Cody, Holman, Theodore R., Holinstat, Michael
Published in Pharmacology research & perspectives (01.02.2023)
Published in Pharmacology research & perspectives (01.02.2023)
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12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets
Yeung, Jennifer, Tourdot, Benjamin E, Adili, Reheman, Green, Abigail R, Freedman, Cody J, Fernandez-Perez, Pilar, Yu, Johnny, Holman, Theodore R, Holinstat, Michael
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.2016)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.10.2016)
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Journal Article
DHA 12‐LOX‐derived oxylipins regulate platelet activation and thrombus formation through a PKA‐dependent signaling pathway
Yamaguchi, Adriana, Stanger, Livia, Freedman, Cody J., Standley, Melissa, Hoang, Timothy, Adili, Reheman, Tsai, Wan‐Chen, Hoorebeke, Christopher, Holman, Theodore R., Holinstat, Michael
Published in Journal of thrombosis and haemostasis (01.03.2021)
Published in Journal of thrombosis and haemostasis (01.03.2021)
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Journal Article
Omega-6 DPA and its 12-lipoxygenase–oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner
Yeung, Jennifer, Adili, Reheman, Yamaguchi, Adriana, Freedman, Cody J., Chen, Angela, Shami, Ryan, Das, Aditi, Holman, Theodore R., Holinstat, Michael
Published in Blood advances (22.09.2020)
Published in Blood advances (22.09.2020)
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Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency
Armstrong, Michelle, van Hoorebeke, Christopher, Horn, Thomas, Deschamps, Joshua, Freedman, J. Cody, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Holman, Theodore
Published in Bioorganic & medicinal chemistry (01.11.2016)
Published in Bioorganic & medicinal chemistry (01.11.2016)
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Journal Article
Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium
Dar, Haider H, Tyurina, Yulia Y, Mikulska-Ruminska, Karolina, Shrivastava, Indira, Ting, Hsiu-Chi, Tyurin, Vladimir A, Krieger, James, St Croix, Claudette M, Watkins, Simon, Bayir, Erkan, Mao, Gaowei, Armbruster, Catherine R, Kapralov, Alexandr, Wang, Hong, Parsek, Matthew R, Anthonymuthu, Tamil S, Ogunsola, Abiola F, Flitter, Becca A, Freedman, Cody J, Gaston, Jordan R, Holman, Theodore R, Pilewski, Joseph M, Greenberger, Joel S, Mallampalli, Rama K, Doi, Yohei, Lee, Janet S, Bahar, Ivet, Bomberger, Jennifer M, Bayır, Hülya, Kagan, Valerian E
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Journal Article
A potent and selective inhibitor targeting human and murine 12/15-LOX
Armstrong, Michelle M., Freedman, Cody J., Jung, Joo Eun, Zheng, Yi, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Simeonov, Anton, Maloney, David J., van Leyen, Klaus, Jadhav, Ajit, Holman, Theodore R.
Published in Bioorganic & medicinal chemistry (15.03.2016)
Published in Bioorganic & medicinal chemistry (15.03.2016)
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Journal Article
12-HETrE, a 12-LOX oxylipin of DGLA, inhibits thrombosis via Gαs signaling in platelets
Yeung, Jennifer, Tourdot, Benjamin E., Adili, Reheman, Green, Abigail R., Freedman, Cody J., Fernandez-Perez, Pilar, Yu, Johnny, Holman, Theodore R., Holinstat, Michael
Published in Arteriosclerosis, thrombosis, and vascular biology (28.07.2016)
Published in Arteriosclerosis, thrombosis, and vascular biology (28.07.2016)
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Journal Article
Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium
Dar, Haider H, Tyurina, Yulia Y, Mikulska-Ruminska, Karolina, Shrivastava, Indira, Ting, Hsiu-Chi, Tyurin, Vladimir A, Krieger, James, St Croix, Claudette M, Watkins, Simon, Bayir, Erkan, Mao, Gaowei, Armbruster, Catherine R, Kapralov, Alexandr, Wang, Hong, Parsek, Matthew R, Anthonymuthu, Tamil S, Ogunsola, Abiola F, Flitter, Becca A, Freedman, Cody J, Gaston, Jordan R, Holman, Theodore R, Pilewski, Joseph M, Greenberger, Joel S, Mallampalli, Rama K, Doi, Yohei, Lee, Janet S, Bahar, Ivet, Bomberger, Jennifer M, Bayır, Hülya, Kagan, Valerian E
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Journal Article