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Acetazolamide-based fungal chitinase inhibitors
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High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules
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Published in Biochemical journal (15.11.2010)
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Published in ChemMedChem (07.12.2009)
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Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase
Patterson, Stephen, Jones, Deuan C., Shanks, Emma J., Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G., Fairlamb, Alan H.
Published in ChemMedChem (03.08.2009)
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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors
Harrison, Justin R, Brand, Stephen, Smith, Victoria, Robinson, David A, Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S, Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C, Stojanovski, Laste, Frearson, Julie A, Brenk, Ruth, Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D
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The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis
Urich, Robert, Grimaldi, Raffaella, Luksch, Torsten, Frearson, Julie A, Brenk, Ruth, Wyatt, Paul G
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Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography
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Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
Baragaña, Beatriz, Norcross, Neil R, Wilson, Caroline, Porzelle, Achim, Hallyburton, Irene, Grimaldi, Raffaella, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C, Wyatt, Paul G, Delves, Michael J, Meister, Stephan, Duffy, Sandra, Avery, Vicky M, Winzeler, Elizabeth A, Sinden, Robert E, Wittlin, Sergio, Frearson, Julie A, Gray, David W, Fairlamb, Alan H, Waterson, David, Campbell, Simon F, Willis, Paul, Read, Kevin D, Gilbert, Ian H
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Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
Cleghorn, Laura A. T., Wall, Richard J., Albrecht, Sébastien, MacGowan, Stuart A., Norval, Suzanne, De Rycker, Manu, Woodland, Andrew, Spinks, Daniel, Thompson, Stephen, Patterson, Stephen, Corpas Lopez, Victoriano, Dey, Gourav, Collie, Iain T., Hallyburton, Irene, Kime, Robert, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Wyllie, Susan
Published in Journal of medicinal chemistry (13.07.2023)
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Cleghorn, Laura A. T, Torrie, Leah S, Frearson, Julie A, Guther, M. Lucia S, Smid, Ondrej, Smith, Deborah F, Stojanovski, Laste, Wilkinson, Anthony J, Wyatt, Paul G, Brannigan, James A, Hui, Raymond, Brand, Stephen, Raimi, Olawale G, Brenk, Ruth, Robinson, David A, Hodgkinson, Michael, Ferguson, Michael A. J, Hallyburton, Irene, Mpamhanga, Chidochangu P, Gilbert, Ian H, McElroy, Stuart P, van Aalten, Daan M. F, Qiu, Wei, Read, Kevin D, Price, Helen P, Fairlamb, Alan H
Published in Nature (01.04.2010)
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Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis
Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Published in Biochemical pharmacology (15.11.2010)
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Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N‑Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
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Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Design and Synthesis of Brain Penetrant Trypanocidal N‑Myristoyltransferase Inhibitors
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Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Target assessment for antiparasitic drug discovery
Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H, Fairlamb, Alan H
Published in Trends in parasitology (01.12.2007)
Published in Trends in parasitology (01.12.2007)
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