Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
BAJRAMI, Ilirjana, FRANKUM, Jessica R, CHEN, Lina, KOZAREWA, Iwanka, ASSIOTIS, Ioannis, FENWICK, Kerry, NATRAJAN, Rachael, LORD, Christopher J, ASHWORTH, Alan, KONDE, Asha, MILLER, Rowan E, REHMAN, Farah L, BROUGH, Rachel, CAMPBELL, James, SIMS, David, RAFIQ, Rumana, HOOPER, Sean
Published in Cancer research (Chicago, Ill.) (01.01.2014)
Published in Cancer research (Chicago, Ill.) (01.01.2014)
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Clinical BRCA1/2 Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance
Pettitt, Stephen J, Frankum, Jessica R, Punta, Marco, Lise, Stefano, Alexander, John, Chen, Yi, Yap, Timothy A, Haider, Syed, Tutt, Andrew N J, Lord, Christopher J
Published in Cancer discovery (01.10.2020)
Published in Cancer discovery (01.10.2020)
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Germline mutations in RAD51D confer susceptibility to ovarian cancer
Rahman, Nazneen, Loveday, Chey, Turnbull, Clare, Ramsay, Emma, Hughes, Deborah, Ruark, Elise, Frankum, Jessica R, Bowden, Georgina, Kalmyrzaev, Bolot, Warren-Perry, Margaret, Snape, Katie, Adlard, Julian W, Barwell, Julian, Berg, Jonathan, Brady, Angela F, Brewer, Carole, Brice, Glen, Chapman, Cyril, Cook, Jackie, Davidson, Rosemarie, Donaldson, Alan, Douglas, Fiona, Greenhalgh, Lynn, Henderson, Alex, Izatt, Louise, Kumar, Ajith, Lalloo, Fiona, Miedzybrodzka, Zosia, Morrison, Patrick J, Paterson, Joan, Porteous, Mary, Rogers, Mark T, Shanley, Susan, Walker, Lisa, Eccles, Diana, Evans, D Gareth, Renwick, Anthony, Seal, Sheila, Lord, Christopher J, Ashworth, Alan, Reis-Filho, Jorge S, Antoniou, Antonis C
Published in Nature genetics (01.09.2011)
Published in Nature genetics (01.09.2011)
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Journal Article
Searching for synthetic lethality in cancer
Brough, Rachel, Frankum, Jessica R, Costa-Cabral, Sara, Lord, Christopher J, Ashworth, Alan
Published in Current opinion in genetics & development (01.02.2011)
Published in Current opinion in genetics & development (01.02.2011)
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Journal Article
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade
Touat, Mehdi, Sourisseau, Tony, Dorvault, Nicolas, Chabanon, Roman M, Garrido, Marlène, Morel, Daphné, Krastev, Dragomir B, Bigot, Ludovic, Adam, Julien, Frankum, Jessica R, Durand, Sylvère, Pontoizeau, Clement, Souquère, Sylvie, Kuo, Mei-Shiue, Sauvaigo, Sylvie, Mardakheh, Faraz, Sarasin, Alain, Olaussen, Ken A, Friboulet, Luc, Bouillaud, Frédéric, Pierron, Gérard, Ashworth, Alan, Lombès, Anne, Lord, Christopher J, Soria, Jean-Charles, Postel-Vinay, Sophie
Published in The Journal of clinical investigation (02.04.2018)
Published in The Journal of clinical investigation (02.04.2018)
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Journal Article
Functional viability profiles of breast cancer
Brough, Rachel, Frankum, Jessica R, Sims, David, Mackay, Alan, Mendes-Pereira, Ana M, Bajrami, Ilirjana, Costa-Cabral, Sara, Rafiq, Rumana, Ahmad, Amar S, Cerone, Maria Antonietta, Natrajan, Rachael, Sharpe, Rachel, Shiu, Kai-Keen, Wetterskog, Daniel, Dedes, Konstantine J, Lambros, Maryou B, Rawjee, Teeara, Linardopoulos, Spiros, Reis-Filho, Jorge S, Turner, Nicholas C, Lord, Christopher J, Ashworth, Alan
Published in Cancer discovery (01.08.2011)
Published in Cancer discovery (01.08.2011)
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Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib
Daemen, Anneleen, Wolf, Denise M., Korkola, James E., Griffith, Obi L., Frankum, Jessica R., Brough, Rachel, Jakkula, Lakshmi R., Wang, Nicholas J., Natrajan, Rachael, Reis-Filho, Jorge S., Lord, Christopher J., Ashworth, Alan, Spellman, Paul T., Gray, Joe W., van’t Veer, Laura J.
Published in Breast cancer research and treatment (01.09.2012)
Published in Breast cancer research and treatment (01.09.2012)
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Journal Article
DNA repair deficiency sensitizes lung cancer cells to NAD^sup +^ biosynthesis blockade
Touat, Mehdi, Sourisseau, Tony, Dorvault, Nicolas, Chabanon, Roman M, Garrido, Marlène, Morel, Daphné, Krastev, Dragomir B, Bigot, Ludovic, Adam, Julien, Frankum, Jessica R, Durand, Sylvère, Pontoizeau, Clement, Souquère, Sylvie, Kuo, Mei-Shiue, Sauvaigo, Sylvie, Mardakheh, Faraz, Sarasin, Alain, Olaussen, Ken A, Friboulet, Luc, Bouillaud, Frédéric, Pierron, Gérard, Ashworth, Alan, Lombès, Anne, Lord, Christopher J, Soria, Jean-Charles, Postel-Vinay, Sophie
Published in The Journal of clinical investigation (01.04.2018)
Published in The Journal of clinical investigation (01.04.2018)
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Journal Article
DNA repair deficiency sensitizes lung cancer cells to [NAD.sup.+] biosynthesis blockade
Touat, Mehdi, Sourisseau, Tony, Dorvault, Nicolas, Chabanon, Roman M, Garrido, Marlene, Morel, Daphne, Krastev, Dragomir B, Bigot, Ludovic, Adam, Julien, Frankum, Jessica R, Durand, Sylvere, Pontoizeau, Clement, Souquere, Sylvie, Kuo, Mei-Shiue, Sauvaigo, Sylvie, Mardakheh, Faraz, Sarasin, Alain, Olaussen, Ken A, Friboulet, Luc, Bouillaud, Frederic, Pierron, Gerard, Ashworth, Alan, Lombes, Anne, Lord, Christopher J, Soria, Jean-Charles, Postel-Vinay, Sophie
Published in The Journal of clinical investigation (01.04.2018)
Published in The Journal of clinical investigation (01.04.2018)
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