HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration
Mielcarek, Michal, Landles, Christian, Weiss, Andreas, Bradaia, Amyaouch, Seredenina, Tamara, Inuabasi, Linda, Osborne, Georgina F, Wadel, Kristian, Touller, Chrystelle, Butler, Rachel, Robertson, Janette, Franklin, Sophie A, Smith, Donna L, Park, Larry, Marks, Paul A, Wanker, Erich E, Olson, Eric N, Luthi-Carter, Ruth, van der Putten, Herman, Beaumont, Vahri, Bates, Gillian P
Published in PLoS biology (01.11.2013)
Published in PLoS biology (01.11.2013)
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SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease
Mielcarek, Michal, Benn, Caroline L, Franklin, Sophie A, Smith, Donna L, Woodman, Ben, Marks, Paul A, Bates, Gillian P
Published in PloS one (28.11.2011)
Published in PloS one (28.11.2011)
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Dysfunction of the CNS-heart axis in mouse models of Huntington's disease
Mielcarek, Michal, Inuabasi, Linda, Bondulich, Marie K, Muller, Thomas, Osborne, Georgina F, Franklin, Sophie A, Smith, Donna L, Neueder, Andreas, Rosinski, Jim, Rattray, Ivan, Protti, Andrea, Bates, Gillian P
Published in PLoS genetics (01.08.2014)
Published in PLoS genetics (01.08.2014)
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HDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophy
Mielcarek, Michal, Toczek, Marta, Smeets, Cleo J L M, Franklin, Sophie A, Bondulich, Marie K, Jolinon, Nelly, Muller, Thomas, Ahmed, Mhoriam, Dick, James R T, Piotrowska, Izabela, Greensmith, Linda, Smolenski, Ryszard T, Bates, Gillian P
Published in PLoS genetics (01.03.2015)
Published in PLoS genetics (01.03.2015)
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HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo
Mielcarek, Michal, Seredenina, Tamara, Stokes, Matthew P, Osborne, Georgina F, Landles, Christian, Inuabasi, Linda, Franklin, Sophie A, Silva, Jeffrey C, Luthi-Carter, Ruth, Beaumont, Vahri, Bates, Gillian P
Published in PloS one (22.11.2013)
Published in PloS one (22.11.2013)
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mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease
Ast, Anne, Buntru, Alexander, Schindler, Franziska, Hasenkopf, Regine, Schulz, Aline, Brusendorf, Lydia, Klockmeier, Konrad, Grelle, Gerlinde, McMahon, Benjamin, Niederlechner, Hannah, Jansen, Isabelle, Diez, Lisa, Edel, Juliane, Boeddrich, Annett, Franklin, Sophie A., Baldo, Barbara, Schnoegl, Sigrid, Kunz, Severine, Purfürst, Bettina, Gaertner, Annette, Kampinga, Harm H., Morton, A. Jennifer, Petersén, Åsa, Kirstein, Janine, Bates, Gillian P., Wanker, Erich E.
Published in Molecular cell (06.09.2018)
Published in Molecular cell (06.09.2018)
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Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice
Bondulich, Marie K., Jolinon, Nelly, Osborne, Georgina F., Smith, Edward J., Rattray, Ivan, Neueder, Andreas, Sathasivam, Kirupa, Ahmed, Mhoriam, Ali, Nadira, Benjamin, Agnesska C., Chang, Xiaoli, Dick, James R. T., Ellis, Matthew, Franklin, Sophie A., Goodwin, Daniel, Inuabasi, Linda, Lazell, Hayley, Lehar, Adam, Richard-Londt, Angela, Rosinski, Jim, Smith, Donna L., Wood, Tobias, Tabrizi, Sarah J., Brandner, Sebastian, Greensmith, Linda, Howland, David, Munoz-Sanjuan, Ignacio, Lee, Se-Jin, Bates, Gillian P.
Published in Scientific reports (27.10.2017)
Published in Scientific reports (27.10.2017)
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B24 Assessment of immune system activation status during the course of disease in huntington’s disease mouse model
Pido-Lopez, Jeffrey, Andre, Ralph, Benjamin, Agnesska, Franklin, Sophie A, Tabrizi, Sarah J, Bates, Gillian P
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2016)
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2016)
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B8 Ablation of p62 modulates levels of soluble and aggregated mutant huntingtin and delays end-stage disease in R6/2 mice
Sathasivam, Kirupa, Paredes, Casandra Gomez, Kuhlbrodt, Kirsten, Thiede, Christina, Reindl, Wolfgang, Smith, Edward J, Benjamin, Agnesska C, Franklin, Sophie A, Whitehouse, Caroline A, Herrmann, Frank, Tillack, Karsten, Macdonald, Douglas, Marchionini, Deanna, Bates, Gillian P
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2016)
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2016)
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Journal Article
HDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophy
Mielcarek, Michal, Toczek, Marta, Smeets, Cleo J.L.M, Franklin, Sophie A, Bondulich, Marie K, Jolinon, Nelly, Muller, Thomas, Ahmed, Mhoriam, Dick, James R.T, Piotrowska, Izabela, Greensmith, Linda, Smolenski, Ryszard T, Bates, Gillian P
Published in PLoS genetics (01.03.2015)
Published in PLoS genetics (01.03.2015)
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HDAC4-Myogenin Axis As an Important Marker of HD-Related Skeletal Muscle Atrophy: e1005021
Mielcarek, Michal, Toczek, Marta, Smeets, J LM, Franklin, Sophie A, Bondulich, Marie K, Jolinon, Nelly, Muller, Thomas, Ahmed, Mhoriam, Dick, James RT, Piotrowska, Izabela, Greensmith, Linda, Smolenski, Ryszard T, Bates, Gillian P
Published in PLoS genetics (01.03.2015)
Published in PLoS genetics (01.03.2015)
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Journal Article
Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease: e1004550
Mielcarek, Michal, Inuabasi, Linda, Bondulich, Marie K, Muller, Thomas, Osborne, Georgina F, Franklin, Sophie A, Smith, Donna L, Neueder, Andreas, Rosinski, Jim, Rattray, Ivan, Protti, Andrea, Bates, Gillian P
Published in PLoS genetics (01.08.2014)
Published in PLoS genetics (01.08.2014)
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Journal Article
B24 Assessment of immune system activation status during the course of disease in huntington’s disease mouse model
Pido-Lopez, Jeffrey, Andre, Ralph, Benjamin, Agnesska, Franklin, Sophie A, Tabrizi, Sarah J, Bates, Gillian P
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2016)
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2016)
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HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration: e1001717
Mielcarek, Michal, Landles, Christian, Weiss, Andreas, Bradaia, Amyaouch, Seredenina, Tamara, Inuabasi, Linda, Osborne, Georgina F, Wadel, Kristian, Touller, Chrystelle, Butler, Rachel, Robertson, Janette, Franklin, Sophie A, Smith, Donna L, Park, Larry, Marks, Paul A, Wanker, Erich E, Olson, Eric N, Luthi-Carter, Ruth, Putten, Herman vander, Beaumont, Vahri, Bates, Gillian P
Published in PLoS biology (01.11.2013)
Published in PLoS biology (01.11.2013)
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