Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol
Goedken, Eric R., Argiriadi, Maria A., Banach, David L., Fiamengo, Bryan A., Foley, Sage E., Frank, Kristine E., George, Jonathan S., Harris, Christopher M., Hobson, Adrian D., Ihle, David C., Marcotte, Douglas, Merta, Philip J., Michalak, Mark E., Murdock, Sara E., Tomlinson, Medha J., Voss, Jeffrey W.
Published in The Journal of biological chemistry (20.02.2015)
Published in The Journal of biological chemistry (20.02.2015)
Get full text
Journal Article
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds
Ramos, Ashley L., Goedken, Eric R., Frank, Kristine E., Argiriadi, Maria A., Bazzaz, Sana, Bian, Zhiguo, Brown, Jesse T. C., Centrella, Paolo A., Chen, Hui-Ju, Disch, Jeremy S., Donner, Pamela L., Duignan, David B., Gikunju, Diana, Greszler, Stephen N., Guié, Marie-Aude, Habeshian, Sevan, Hartl, Hajnalka E., Hein, Christopher D., Hutchins, Charles W., Jetson, Rachael, Keefe, Anthony D., Khan, Hasan, Li, Huan-Qiu, Olszewski, Allison, Ortiz Cardona, Benjamin J., Osuma, Augustine, Panchal, Sanjay C., Phelan, Ryan, Qiu, Wei, Shotwell, J. Brad, Shrestha, Anurupa, Srikumaran, Myron, Su, Zhi, Sun, Chaohong, Upadhyay, Anup K., Wood, Michael D., Wu, Haihong, Zhang, Ruijie, Zhang, Ying, Zhao, Gang, Zhu, Haizhong, Webster, Matthew P.
Published in Journal of medicinal chemistry (25.04.2024)
Published in Journal of medicinal chemistry (25.04.2024)
Get full text
Journal Article
Therapeutic JAK1 Inhibition Reverses Lupus Nephritis in a Mouse Model and Demonstrates Transcriptional Changes Consistent With Human Disease
Twomey, Rachel E, Perper, Stuart J, Westmoreland, Susan V, Srinivasan, Swetha, Mathieu, Suzanne L, Frank, Kristine E, Karman, Jozsef, Long, Andrew J, Housley, William J, Clarke, Stephen H
Published in ACR open rheumatology (04.10.2024)
Published in ACR open rheumatology (04.10.2024)
Get full text
Journal Article
Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors
Friedman, Michael, Frank, Kristine E., Aguirre, Ana, Argiriadi, Maria A., Davis, Heather, Edmunds, Jeremy J., George, Dawn M., George, Jonathan S., Goedken, Eric, Fiamengo, Bryan, Hyland, Deborah, Li, Bin, Murtaza, Anwar, Morytko, Michael, Somal, Gagandeep, Stewart, Kent, Tarcsa, Edit, Van Epps, Stacy, Voss, Jeffrey, Wang, Lu, Woller, Kevin, Wishart, Neil
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Get full text
Journal Article
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization
Harris, Christopher M., Ericsson, Anna M., Argiriadi, Maria A., Barberis, Claude, Borhani, David W., Burchat, Andrew, Calderwood, David J., Cunha, George A., Dixon, Richard W., Frank, Kristine E., Johnson, Eric F., Kamens, Joanne, Kwak, Silvia, Li, Biqin, Mullen, Kelly D., Perron, Denise C., Wang, Lu, Wishart, Neil, Wu, Xiaoyun, Zhang, Xiaolei, Zmetra, Tami R., Talanian, Robert V.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
Get full text
Journal Article
Ring expansion by in situ tethering of hydroxy azides to ketones: The boyer reaction
Gracias, Vijaya, Frank, Kristine E., Milligan, Gregory L., Aubé, Jeffrey
Published in Tetrahedron (01.12.1997)
Published in Tetrahedron (01.12.1997)
Get full text
Journal Article
NOVEL TRICYCLIC COMPOUNDS
WOLLER KEVIN R, FRANK KRISTINE E, ERICSSON ANNA M, VOSS JEFFREY W, FRIEDMAN MICHAEL, WISHART NEIL, MORYTKO MICHAEL J, CALDERWOOD DAVID J, FIAMENGO BRYAN A, WALLACE GRIER A, WANG LU, JOSEPHSOHN NATHAN S, ARGIRIADI MARIA A, GOEDKEN ERIC R, GEORGE DAWN M, LI BIQIN C, STEWART KENT D
Year of Publication 12.09.2018
Get full text
Year of Publication 12.09.2018
Patent
NOVEL TRICYCLIC COMPOUNDS
WOLLER KEVIN R, FRANK KRISTINE E, ERICSSON ANNA M, VOSS JEFFREY W, FRIEDMAN MICHAEL, WISHART NEIL, MORYTKO MICHAEL J, CALDERWOOD DAVID J, FIAMENGO BRYAN A, WALLACE GRIER A, WANG LU, JOSEPHSOHN NATHAN S, ARGIRIADI MARIA A, GOEDKEN ERIC R, GEORGE DAWN M, LI BIQIN C, STEWART KENT D
Year of Publication 24.10.2017
Get full text
Year of Publication 24.10.2017
Patent
CYANOGUANIDINES AND THEIR USE AS ANTIVIRAL AGENTS
FRIEDMAN MICHAEL M, FRANK KRISTINE E, JOSEPHSOHN NATHAN, GOMTSIAN ARTOUR, VASUDEVAN ANIL, NG TERESA, DEKHTYAR TATYANA, MOLLA M AKHTERUZZ, CHAFEEV MIKHAIL
Year of Publication 25.03.2015
Get full text
Year of Publication 25.03.2015
Patent
Novel tricyclic compounds
WOLLER KEVIN R, FRANK KRISTINE E, ERICSSON ANNA M, VOSS JEFFREY W, FRIEDMAN MICHAEL, WISHART NEIL, MORYTKO MICHAEL J, CALDERWOOD DAVID J, FIAMENGO BRYAN A, WALLACE GRIER A, WANG LU, JOSEPHSOHN NATHAN S, ARGIRIADI MARIA A, GOEDKEN ERIC R, GEORGE DAWN M, LI BIQIN C, STEWART KENT D
Year of Publication 23.12.2016
Get full text
Year of Publication 23.12.2016
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
FRANK KRISTINE E, HOEMANN MICHAEL Z, WILSON NOEL S, OSUMA AUGUSTINE, SHEPPARD GEORGE, BONAFOUX DOMINIQUE, VAN CAMP JENNIFER, VAN EPPS STACY A, HUNTLEY RAYMOND, SOMAL GAGANDEEP K, XU XIANGDONG, WALLACE GRIER A, WANG LU, DAVIS HEATHER M, FRIEDMAN MICHAEL M, VASUDEVAN ANIL, HEROLD J. MARTIN, WANG ZHI
Year of Publication 08.03.2016
Get full text
Year of Publication 08.03.2016
Patent
NOVEL TRICYCLIC COMPOUNDS
WOLLER KEVIN R, FRANK KRISTINE E, ERICSSON ANNA M, VOSS JEFFREY W, FRIEDMAN MICHAEL, WISHART NEIL, MORYTKO MICHAEL J, CALDERWOOD DAVID J, FIAMENGO BRYAN A, WALLACE GRIER A, WANG LU, JOSEPHSOHN NATHAN S, ARGIRIADI MARIA A, GOEDKEN ERIC R, GEORGE DAWN M, LI BIQIN C, STEWART KENT D
Year of Publication 06.02.2014
Get full text
Year of Publication 06.02.2014
Patent
NOVEL TRICYCLIC COMPOUNDS
WOLLER KEVIN R, FRANK KRISTINE E, HOEMANN MICHAEL Z, ERICSSON ANNA M, VOSS JEFFREY W, FRIEDMAN MICHAEL, WISHART NEIL, MORYTKO MICHAEL J, CALDERWOOD DAVID J, FIAMENGO BRYAN A, WALLACE GRIER A, WANG LU, JOSEPHSOHN NATHAN S, ARGIRIADI MARIA A, GOEDKEN ERIC R, BREINLINGER ERIC C, GEORGE DAWN M, SOMAL GAGANDEEP, MULLEN KELLY D, LI BIQIN C, STEWART KENT D
Year of Publication 18.09.2012
Get full text
Year of Publication 18.09.2012
Patent
NOVEL TRICYCLIC COMPOUNDS
WOLLER KEVIN R, FRANK KRISTINE E, ERICSSON ANNA M, VOSS JEFFREY W, FRIEDMAN MICHAEL, WISHART NEIL, MORYTKO MICHAEL J, CALDERWOOD DAVID J, FIAMENGO BRYAN A, WALLACE GRIER A, WANG LU, JOSEPHSOHN NATHAN S, ARGIRIADI MARIA A, GOEDKEN ERIC R, GEORGE DAWN M, LI BIQIN C, STEWART KENT D
Year of Publication 21.02.2011
Get full text
Year of Publication 21.02.2011
Patent
NOVEL TRICYCLIC COMPOUNDS
FRANK, Kristine E, VOSS, Jeffrey W, ARGIRIADI, Maria A, WISHART, Neil, FIAMENGO, Bryan A, WOLLER, Kevin R, Ericsson, Anna M, GEORGE, Dawn M, STEWART, Kent D, JOSEPHSOHN, Nathan S, FRIEDMAN, Michael M, LI, Biqin C, WALLACE, Grier A, MORYTKO, Michael J, WANG, Lu, CALDERWOOD, David J, GOEDKEN, Eric R
Year of Publication 16.03.2023
Get full text
Year of Publication 16.03.2023
Patent
Tricyclic compounds
Frank, Kristine E, Friedman, Michael, Stewart, Kent D, Wishart, Neil, Wallace, Grier A, George, Dawn M
Year of Publication 05.02.2019
Get full text
Year of Publication 05.02.2019
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
BONAFOUX, Dominique, OSUMA, Augustine, HUNTLEY, Raymond, SOMAL, Gagandeep, K, WALLACE, Grier, A, FRIEDMAN, Michael, M, VASUDEVAN, Anil, HOEMANN, Michael, Z, HEROLD, J. Martin, VAN CAMP, Jennifer, VAN EPPS, Stacy, A, SHEPPARD, George, FRANK, Kristine, E, XU, Xiangdong, DAVIS, Heather, M, WANG, Lu, WANG, Zhi, WILSON, Noel, S
Year of Publication 08.06.2022
Get full text
Year of Publication 08.06.2022
Patent