514 Disturbed Mitochondrial Dynamics Rewire the Epigenetic Program for CD8+ TIL Exhaustion
Yu, Yi-Ru, Wang, Haiping, Franco, Fabien, Ho, Ping-Chih
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Microbes and vitamin D aid immunotherapy
Franco, Fabien, McCoy, Kathy D
Published in Science (American Association for the Advancement of Science) (26.04.2024)
Published in Science (American Association for the Advancement of Science) (26.04.2024)
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Metabolic and epigenetic regulation of T-cell exhaustion
Franco, Fabien, Jaccard, Alison, Romero, Pedro, Yu, Yi-Ru, Ho, Ping-Chih
Published in Nature metabolism (01.10.2020)
Published in Nature metabolism (01.10.2020)
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Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity
Guo, Yugang, Xie, Yu-Qing, Gao, Min, Zhao, Yang, Franco, Fabien, Wenes, Mathias, Siddiqui, Imran, Bevilacqua, Alessio, Wang, Haiping, Yang, Hanshuo, Feng, Bing, Xie, Xin, Sabatel, Catherine M., Tschumi, Benjamin, Chaiboonchoe, Amphun, Wang, Yuxi, Li, Weimin, Xiao, Weihua, Held, Werner, Romero, Pedro, Ho, Ping-Chih, Tang, Li
Published in Nature immunology (01.06.2021)
Published in Nature immunology (01.06.2021)
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Journal Article
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
Wang, Haiping, Franco, Fabien, Tsui, Yao-Chen, Xie, Xin, Trefny, Marcel P., Zappasodi, Roberta, Mohmood, Syed Raza, Fernández-García, Juan, Tsai, Chin-Hsien, Schulze, Isabell, Picard, Florence, Meylan, Etienne, Silverstein, Roy, Goldberg, Ira, Fendt, Sarah-Maria, Wolchok, Jedd D., Merghoub, Taha, Jandus, Camilla, Zippelius, Alfred, Ho, Ping-Chih
Published in Nature immunology (01.03.2020)
Published in Nature immunology (01.03.2020)
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Journal Article
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
Yu, Yi-Ru, Imrichova, Hana, Wang, Haiping, Chao, Tung, Xiao, Zhengtao, Gao, Min, Rincon-Restrepo, Marcela, Franco, Fabien, Genolet, Raphael, Cheng, Wan-Chen, Jandus, Camilla, Coukos, George, Jiang, Yi-Fan, Locasale, Jason W., Zippelius, Alfred, Liu, Pu-Ste, Tang, Li, Bock, Christoph, Vannini, Nicola, Ho, Ping-Chih
Published in Nature immunology (01.12.2020)
Published in Nature immunology (01.12.2020)
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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
Wenes, Mathias, Jaccard, Alison, Wyss, Tania, Maldonado-Pérez, Noelia, Teoh, Shao Thing, Lepez, Anouk, Renaud, Fabrice, Franco, Fabien, Waridel, Patrice, Yacoub Maroun, Céline, Tschumi, Benjamin, Dumauthioz, Nina, Zhang, Lianjun, Donda, Alena, Martín, Francisco, Migliorini, Denis, Lunt, Sophia Y., Ho, Ping-Chih, Romero, Pedro
Published in Cell metabolism (03.05.2022)
Published in Cell metabolism (03.05.2022)
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Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity
Di Conza, Giusy, Tsai, Chin-Hsien, Gallart-Ayala, Hector, Yu, Yi-Ru, Franco, Fabien, Zaffalon, Lea, Xie, Xin, Li, Xiaoyun, Xiao, Zhengtao, Raines, Lydia N., Falquet, Maryline, Jalil, Antoine, Locasale, Jason W., Percipalle, Piergiorgio, Masson, David, Huang, Stanley Ching-Cheng, Martinon, Fabio, Ivanisevic, Julijana, Ho, Ping-Chih
Published in Nature immunology (01.11.2021)
Published in Nature immunology (01.11.2021)
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Journal Article
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
Dumauthioz, Nina, Tschumi, Benjamin, Wenes, Mathias, Marti, Bastien, Wang, Haiping, Franco, Fabien, Li, Wenhui, Lopez-Mejia, Isabel C., Fajas, Lluis, Ho, Ping-Chih, Donda, Alena, Romero, Pedro, Zhang, Lianjun
Published in Cellular & molecular immunology (01.07.2021)
Published in Cellular & molecular immunology (01.07.2021)
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Journal Article
Reductive carboxylation epigenetically instructs T cell differentiation
Jaccard, Alison, Wyss, Tania, Maldonado-Pérez, Noelia, Rath, Jan A., Bevilacqua, Alessio, Peng, Jhan-Jie, Lepez, Anouk, Von Gunten, Christine, Franco, Fabien, Kao, Kung-Chi, Camviel, Nicolas, Martín, Francisco, Ghesquière, Bart, Migliorini, Denis, Arber, Caroline, Romero, Pedro, Ho, Ping-Chih, Wenes, Mathias
Published in Nature (London) (28.09.2023)
Published in Nature (London) (28.09.2023)
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Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle
Cheng, Wan-Chen, Tsui, Yao-Chen, Ragusa, Simone, Koelzer, Viktor H., Mina, Marco, Franco, Fabien, Läubli, Heinz, Tschumi, Benjamin, Speiser, Daniel, Romero, Pedro, Zippelius, Alfred, Petrova, Tatiana V., Mertz, Kirsten, Ciriello, Giovanni, Ho, Ping-Chih
Published in Nature immunology (01.02.2019)
Published in Nature immunology (01.02.2019)
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CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation
Fernández-García, Juan, Franco, Fabien, Parik, Sweta, Altea-Manzano, Patricia, Pane, Antonino Alejandro, Broekaert, Dorien, van Elsen, Joke, Di Conza, Giusy, Vermeire, Ines, Schalley, Tessa, Planque, Mélanie, van Brussel, Thomas, Schepers, Rogier, Modave, Elodie, Karakach, Tobias K., Carmeliet, Peter, Lambrechts, Diether, Ho, Ping-Chih, Fendt, Sarah-Maria
Published in Cell reports (Cambridge) (15.11.2022)
Published in Cell reports (Cambridge) (15.11.2022)
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Journal Article
Metabolic reprogramming of terminally exhausted CD8.sup.+ T cells by IL-10 enhances anti-tumor immunity
Guo, Yugang, Xie, Yu-Qing, Gao, Min, Zhao, Yang, Franco, Fabien, Wenes, Mathias, Siddiqui, Imran, Bevilacqua, Alessio, Wang, Haiping, Yang, Hanshuo, Feng, Bing, Sabatel, Catherine M, Tschumi, Benjamin, Chaiboonchoe, Amphun, Wang, Yuxi, Li, Weimin, Xiao, Weihua, Heid, Werner, Xie, Xin
Published in Nature immunology (01.06.2021)
Published in Nature immunology (01.06.2021)
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Journal Article
Tumor-induced reshuffling of lipid composition on the ER membrane sustains macrophage survival and pro-tumorigenic activity
Di Conza, Giusy, Tsai, Chin-Hsien, Gallart-Ayala, Hector, Yu, Yi-Ru, Franco, Fabien, Zaffalon, Lea, Xie, Xin, Li, Xiaoyun, Xiao, Zhengtao, Raines, Lydia N., Falquet, Maryline, Jalil, Antoine, Locasale, Jason W., Percipalle, Piergiorgio, Masson, David, Huang, Stanley Ching-Cheng, Martinon, Fabio, Ivanisevic, Julijana, Ho, Ping-Chih
Published in Nature immunology (22.10.2021)
Published in Nature immunology (22.10.2021)
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PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8 + T cells
Bevilacqua, Alessio, Franco, Fabien, Lu, Ya-Ting, Rahiman, Nabil, Kao, Kung-Chi, Chuang, Yu-Ming, Zhu, Yanan, Held, Werner, Xie, Xin, Gunsalus, Kristin C, Xiao, Zhengtao, Chen, Shih-Yu, Ho, Ping-Chih
Published in Science immunology (23.08.2024)
Published in Science immunology (23.08.2024)
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Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems
Girotra, Mukul, Chiang, Yi-Hsuan, Charmoy, Melanie, Ginefra, Pierpaolo, Hope, Helen Carrasco, Bataclan, Charles, Yu, Yi-Ru, Schyrr, Frederica, Franco, Fabien, Geiger, Hartmut, Cherix, Stephane, Ho, Ping-Chih, Naveiras, Olaia, Auwerx, Johan, Held, Werner, Vannini, Nicola
Published in Nature aging (01.09.2023)
Published in Nature aging (01.09.2023)
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Publisher Correction: Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle
Cheng, Wan-Chen, Tsui, Yao-Chen, Ragusa, Simone, Koelzer, Viktor H., Mina, Marco, Franco, Fabien, Läubli, Heinz, Tschumi, Benjamin, Speiser, Daniel, Romero, Pedro, Zippelius, Alfred, Petrova, Tatiana V., Mertz, Kirsten, Ciriello, Giovanni, Ho, Ping-Chih
Published in Nature immunology (01.04.2019)
Published in Nature immunology (01.04.2019)
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