N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis
Warrier, Thulasi, Kapilashrami, Kanishk, Argyrou, Argyrides, Ioerger, Thomas R., Little, David, Murphy, Kenan C., Nandakumar, Madhumitha, Park, Suna, Gold, Ben, Mi, Jianjie, Zhang, Tuo, Meiler, Eugenia, Rees, Mike, Somersan-Karakaya, Selin, Francisco, Esther Porras-De, Martinez-Hoyos, Maria, Burns-Huang, Kristin, Roberts, Julia, Ling, Yan, Rhee, Kyu Y., Mendoza-Losana, Alfonso, Luo, Minkui, Nathan, Carl F.
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Get full text
Journal Article
Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence
Dutta, Noton K, Klinkenberg, Lee G, Vazquez, Maria-Jesus, Segura-Carro, Delfina, Colmenarejo, Gonzalo, Ramon, Fernando, Rodriguez-Miquel, Beatriz, Mata-Cantero, Lydia, Porras-De Francisco, Esther, Chuang, Yu-Min, Rubin, Harvey, Lee, Jae Jin, Eoh, Hyungjin, Bader, Joel S, Perez-Herran, Esther, Mendoza-Losana, Alfonso, Karakousis, Petros C
Published in Science advances (01.03.2019)
Published in Science advances (01.03.2019)
Get full text
Journal Article
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis
Flipo, Marion, Frita, Rosangela, Bourotte, Marilyne, Martínez-Martínez, María S, Boesche, Markus, Boyle, Gary W, Derimanov, Geo, Drewes, Gerard, Gamallo, Pablo, Ghidelli-Disse, Sonja, Gresham, Stephanie, Jiménez, Elena, de Mercado, Jaime, Pérez-Herrán, Esther, Porras-De Francisco, Esther, Rullas, Joaquín, Casado, Patricia, Leroux, Florence, Piveteau, Catherine, Kiass, Mehdi, Mathys, Vanessa, Soetaert, Karine, Megalizzi, Véronique, Tanina, Abdalkarim, Wintjens, René, Antoine, Rudy, Brodin, Priscille, Delorme, Vincent, Moune, Martin, Djaout, Kamel, Slupek, Stéphanie, Kemmer, Christian, Gitzinger, Marc, Ballell, Lluis, Mendoza-Losana, Alfonso, Lociuro, Sergio, Deprez, Benoit, Barros-Aguirre, David, Remuiñán, Modesto J, Willand, Nicolas, Baulard, Alain R
Published in Science translational medicine (04.05.2022)
Published in Science translational medicine (04.05.2022)
Get more information
Journal Article
Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis
Guardia, Ana, Baiget, Jessica, Cacho, Mónica, Pérez, Arancha, Ortega-Guerra, Montserrat, Nxumalo, Winston, Khanye, Setshaba D, Rullas, Joaquín, Ortega, Fátima, Jiménez, Elena, Pérez-Herrán, Esther, Fraile-Gabaldón, María Teresa, Esquivias, Jorge, Fernández, Raquel, Porras-De Francisco, Esther, Encinas, Lourdes, Alonso, Marta, Giordano, Ilaria, Rivero, Cristina, Miguel-Siles, Juan, Osende, Javier G, Badiola, Katrina A, Rutledge, Peter J, Todd, Matthew H, Remuiñán, Modesto, Alemparte, Carlos
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
Get full text
Journal Article
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis
Lopez Quezada, Landys, Li, Kelin, McDonald, Stacey L, Nguyen, Quyen, Perkowski, Andrew J, Pharr, Cameron W, Gold, Ben, Roberts, Julia, McAulay, Kathrine, Saito, Kohta, Somersan Karakaya, Selin, Javidnia, Prisca Elis, Porras de Francisco, Esther, Amieva, Manuel Marin, Dı́az, Sara Palomo, Mendoza Losana, Alfonso, Zimmerman, Matthew, Liang, Hsin-Pin Ho, Zhang, Jun, Dartois, Veronique, Sans, Stéphanie, Lagrange, Sophie, Goullieux, Laurent, Roubert, Christine, Nathan, Carl, Aubé, Jeffrey
Published in ACS infectious diseases (09.08.2019)
Published in ACS infectious diseases (09.08.2019)
Get full text
Journal Article
MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis
Moure, Abraham L, Narula, Gagandeep, Sorrentino, Flavia, Bojang, Adama, Tsui, Clement K. M, Sao Emani, Carine, Porras-De Francisco, Esther, Díaz, Beatriz, Rebollo-López, María José, Torres-Gómez, Pedro Alfonso, López-Román, Eva María, Camino, Isabel, Casado Castro, Patricia, Guijarro López, Laura, Ortega, Fátima, Ballell, Lluis, Barros-Aguirre, David, Remuiñán Blanco, Modesto, Av-Gay, Yossef
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
Get full text
Journal Article
Identification of β‑Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions
Gold, Ben, Zhang, Jun, Quezada, Landys Lopez, Roberts, Julia, Ling, Yan, Wood, Madeleine, Shinwari, Wasima, Goullieux, Laurent, Roubert, Christine, Fraisse, Laurent, Bacqué, Eric, Lagrange, Sophie, Filoche-Rommé, Bruno, Vieth, Michal, Hipskind, Philip A, Jungheim, Louis N, Aubé, Jeffrey, Scarry, Sarah M, McDonald, Stacey L, Li, Kelin, Perkowski, Andrew, Nguyen, Quyen, Dartois, Véronique, Zimmerman, Matthew, Olsen, David B, Young, Katherine, Bonnett, Shilah, Joerss, Douglas, Parish, Tanya, Boshoff, Helena I, Arora, Kriti, Barry, Clifton E, Guijarro, Laura, Anca, Sara, Rullas, Joaquín, Rodríguez-Salguero, Beatriz, Martínez-Martínez, Maria S, Porras-De Francisco, Esther, Cacho, Monica, Barros-Aguirre, David, Smith, Paul, Berthel, Steven J, Nathan, Carl, Bates, Robert H
Published in ACS infectious diseases (11.03.2022)
Published in ACS infectious diseases (11.03.2022)
Get full text
Journal Article
Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis
Warrier, Thulasi, Martinez-Hoyos, Maria, Marin-Amieva, Manuel, Colmenarejo, Gonzalo, Porras-De Francisco, Esther, Alvarez-Pedraglio, Ana Isabel, Fraile-Gabaldon, Maria Teresa, Torres-Gomez, Pedro Alfonso, Lopez-Quezada, Landys, Gold, Ben, Roberts, Julia, Ling, Yan, Somersan-Karakaya, Selin, Little, David, Cammack, Nicholas, Nathan, Carl, Mendoza-Losana, Alfonso
Published in ACS infectious diseases (11.12.2015)
Published in ACS infectious diseases (11.12.2015)
Get full text
Journal Article
Correction to “Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis”
Quezada, Landys Lopez, Li, Kelin, McDonald, Stacey L, Nguyen, Quyen, Perkowski, Andrew J, Pharr, Cameron W, Gold, Ben, Roberts, Julia, McAulay, Kathrine, Saito, Kohta, Karakaya, Selin Somersan, Javidnia, Prisca Elis, Porras de Francisco, Esther, Amieva, Manuel Marin, Palomo, Sara, Losana, Alfonso Mendoza, Zimmerman, Matthew, Ho Liang, Hsin-Pin, Zhang, Jun, Dartois, Veronique, Sans, Stéphanie, Lagrange, Sophie, Goullieux, Laurent, Roubert, Christine, Nathan, Carl, Aubé, Jeffrey
Published in ACS infectious diseases (13.12.2019)
Published in ACS infectious diseases (13.12.2019)
Get full text
Journal Article
Compounds
Deprez, Benoit, Bourotte, Marilyne, Porras De Francisco, Esther, Willand, Nicolas, Remuiñan-Blanco, Modesto Jesús
Year of Publication 30.04.2024
Get full text
Year of Publication 30.04.2024
Patent
NOVEL COMPOUNDS
Deprez, Benoit, Porras de Francisco, Esther, Bourotte, Marilyne, Willand, Nicolas, Remuiñan-Blanco, Modesto Jesús
Year of Publication 19.08.2022
Get full text
Year of Publication 19.08.2022
Patent
NOVEL COMPOUNDS
Deprez, Benoit, Porras de Francisco, Esther, Bourotte, Marilyne, Willand, Nicolas, Remuiñan-Blanco, Modesto Jesús
Year of Publication 19.08.2022
Get full text
Year of Publication 19.08.2022
Patent
Compounds
Deprez, Benoit, Bourotte, Marilyne, Porras De Francisco, Esther, Willand, Nicolas, Remuiñan-Blanco, Modesto Jesús, Dequirez, Geoffroy
Year of Publication 22.02.2022
Get full text
Year of Publication 22.02.2022
Patent
Compounds
Deprez, Benoit, Bourotte, Marilyne, Porras De Francisco, Esther, Willand, Nicolas, Remuiñan-Blanco, Modesto Jesús
Year of Publication 22.02.2022
Get full text
Year of Publication 22.02.2022
Patent
NOVEL COMPOUNDS
PORRAS DE FRANCISCO, Esther, BOUROTTE, Marilyne, DEPREZ, Benoit, WILLAND, Nicolas, REMUINAN-BLANCO, Modesto Jesus
Year of Publication 19.09.2024
Get full text
Year of Publication 19.09.2024
Patent
NOVEL COMPOUNDS
PORRAS DE FRANCISCO Esther, WILLAND Nicolas, BOUROTTE Marilyne, DEPREZ Benoit, REMUINAN-BLANCO Modesto Jesus
Year of Publication 29.04.2022
Get full text
Year of Publication 29.04.2022
Patent
NOVEL COMPOUNDS
PORRAS DE FRANCISCO, Esther, BOUROTTE, Marilyne, DEPREZ, Benoit, WILLAND, Nicolas, REMUINAN-BLANCO, Modesto Jesus
Year of Publication 28.04.2022
Get full text
Year of Publication 28.04.2022
Patent
NOVEL COMPOUNDS
PORRAS DE FRANCISCO, Esther, BOUROTTE, Marilyne, DEPREZ, Benoit, WILLAND, Nicolas, REMUINAN-BLANCO, Modesto Jesus
Year of Publication 28.03.2022
Get full text
Year of Publication 28.03.2022
Patent
NOVEL COMPOUNDS
PORRAS DE FRANCISCO, Esther, BOUROTTE, Marilyne, REMUIÑAN-BLANCO, Modesto Jesús, DEPREZ, Benoit, WILLAND, Nicolas
Year of Publication 25.03.2022
Get full text
Year of Publication 25.03.2022
Patent
NOVEL COMPOUNDS
PORRAS DE FRANCISCO, Esther, BOUROTTE, Marilyne, REMUIÑAN-BLANCO, Modesto Jesús, DEPREZ, Benoit, WILLAND, Nicolas
Year of Publication 10.03.2022
Get full text
Year of Publication 10.03.2022
Patent