The Methylation Effect in Medicinal Chemistry
Barreiro, Eliezer J, Kümmerle, Arthur E, Fraga, Carlos A. M
Published in Chemical reviews (14.09.2011)
Published in Chemical reviews (14.09.2011)
Get full text
Journal Article
Design, Synthesis, and Pharmacological Evaluation of Novel N‑Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors
Rodrigues, Daniel A, Ferreira-Silva, Guilherme À, Ferreira, Ana C. S, Fernandes, Renan A, Kwee, Jolie K, Sant’Anna, Carlos M. R, Ionta, Marisa, Fraga, Carlos A. M
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
Get full text
Journal Article
Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 Inhibitors
Kümmerle, Arthur E, Schmitt, Martine, Cardozo, Suzana V. S, Lugnier, Claire, Villa, Pascal, Lopes, Alexandra B, Romeiro, Nelilma C, Justiniano, Hélène, Martins, Marco A, Fraga, Carlos A. M, Bourguignon, Jean-Jacques, Barreiro, Eliezer J
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
Get full text
Journal Article
Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile
Pillpe-Meza, Raysa Magali, Gouveia, Wesley Leandro, Barbosa, Gisele, Fraga, Carlos A M, Barreiro, Eliezer J, Lima, Lidia Moreira
Published in Pharmaceuticals (Basel, Switzerland) (01.03.2024)
Published in Pharmaceuticals (Basel, Switzerland) (01.03.2024)
Get full text
Journal Article
Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2- a]pyridine symbiotic prototypes
Lacerda, Renata B., de Lima, Cleverton K.F., da Silva, Leandro L., Romeiro, Nelilma C., Miranda, Ana Luisa P., Barreiro, Eliezer J., Fraga, Carlos A.M.
Published in Bioorganic & medicinal chemistry (2009)
Published in Bioorganic & medicinal chemistry (2009)
Get full text
Journal Article
Structure-property relationship studies of 3-acyl-substituted furans: the serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety
Rodrigues, Daniel A, Pinheiro, Pedro de Sena M, Sagrillo, Fernanda, Freitas, Maria Clara, Alves, Marina, Thota, Sreekanth, Tinoco, Luzineide W, Magalhães, Alvicler, Sant'Anna, Carlos M. R, Fraga, Carlos A. M
Published in New journal of chemistry (14.07.2020)
Published in New journal of chemistry (14.07.2020)
Get full text
Journal Article
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents
Carvalho, Samir A., Feitosa, Larisse O., Soares, Márcio, Costa, Thadeu E.M.M., Henriques, Maria G., Salomão, Kelly, de Castro, Solange L., Kaiser, Marcel, Brun, Reto, Wardell, James L., Wardell, Solange M.S.V., Trossini, Gustavo H.G., Andricopulo, Adriano D., da Silva, Edson F., Fraga, Carlos A.M.
Published in European journal of medicinal chemistry (01.08.2012)
Published in European journal of medicinal chemistry (01.08.2012)
Get full text
Journal Article
New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia
Neves, Gilda, Antonio, Camila B., Betti, Andresa H., Pranke, Mariana A., Fraga, Carlos A.M., Barreiro, Eliezer J., Noël, François, Rates, Stela M.K.
Published in Behavioural brain research (15.01.2013)
Published in Behavioural brain research (15.01.2013)
Get full text
Journal Article
Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
Kümmerle, Arthur E., Raimundo, Juliana M., Leal, Carla M., da Silva, Givanildo S., Balliano, Tatiane L., Pereira, Mariano A., de Simone, Carlos A., Sudo, Roberto T., Zapata-Sudo, Gisele, Fraga, Carlos A.M., Barreiro, Eliezer J.
Published in European journal of medicinal chemistry (01.10.2009)
Published in European journal of medicinal chemistry (01.10.2009)
Get full text
Journal Article
Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties
Bezerra-Netto, Heleno J.C., Lacerda, Daniel I., Miranda, Ana Luisa P., Alves, Hélio M., Barreiro, Eliezer J., Fraga, Carlos A.M.
Published in Bioorganic & medicinal chemistry (01.12.2006)
Published in Bioorganic & medicinal chemistry (01.12.2006)
Get full text
Journal Article
N -acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity
Alencar, Allan K.N, Pereira, Sharlene L, da Silva, Flavia E, Mendes, Luiza V.P, Cunha, Valéria do M.N, Lima, Lidia M, Montagnoli, Tadeu L, Caruso-Neves, Celso, Ferraz, Emanuelle B, Tesch, Roberta, Nascimento, José H.M, Sant'Anna, Carlos M.R, Fraga, Carlos A.M, Barreiro, Eliezer J, Sudo, Roberto T, Zapata-Sudo, Gisele
Published in International journal of cardiology (01.05.2014)
Published in International journal of cardiology (01.05.2014)
Get full text
Journal Article
Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)
Kümmerle, Arthur E., Vieira, Marina M., Schmitt, Martine, Miranda, Ana L.P., Fraga, Carlos A.M., Bourguignon, Jean-Jacques, Barreiro, Eliezer J.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Get full text
Journal Article
Microwave-assisted synthesis and structure–activity relationships of neuroactive pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivatives
Nascimento-Júnior, Nailton M., Mendes, Thaiana C.F., Leal, Daniella M., Corrêa, Claudia Maria N., Sudo, Roberto T., Zapata-Sudo, Gisele, Barreiro, Eliezer J., Fraga, Carlos A.M.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
Get full text
Journal Article
2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties
de Oliveira, Daniela R, Maia, Rodolfo C, de Carvalho França, Patrícia R, Fernandes, Patrícia D, Barbosa, Gisele, Lima, Lídia M, Fraga, Carlos A Manssour
Published in Pharmaceuticals (Basel, Switzerland) (01.12.2022)
Published in Pharmaceuticals (Basel, Switzerland) (01.12.2022)
Get full text
Journal Article