The tetrodotoxin binding site is within the outer vestibule of the sodium channel
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Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels
Sheets, Michael F., Fozzard, Harry A., Hanck, Dorothy A.
Published in Biophysical journal (01.12.2015)
Published in Biophysical journal (01.12.2015)
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The sodium channel as a target for local anesthetic drugs
Fozzard, Harry A, Sheets, Michael F, Hanck, Dorothy A
Published in Frontiers in pharmacology (01.01.2011)
Published in Frontiers in pharmacology (01.01.2011)
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Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels
McNulty, Megan M., Edgerton, Gabrielle B., Shah, Ravi D., Hanck, Dorothy A., Fozzard, Harry A., Lipkind, Gregory M.
Published in The Journal of physiology (01.06.2007)
Published in The Journal of physiology (01.06.2007)
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A molecular model of the inner pore of the Ca channel in its open state
Lipkind, Gregory M., Fozzard, Harry A., Hanck, Dorothy A.
Published in Channels (Austin, Tex.) (01.11.2011)
Published in Channels (Austin, Tex.) (01.11.2011)
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Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents
Sunami, Akihiko, Tracey, Arlene, Glaaser, Ian W., Lipkind, Gregory M., Hanck, Dorothy A., Fozzard, Harry A.
Published in The Journal of physiology (01.12.2004)
Published in The Journal of physiology (01.12.2004)
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Sodium Channel Selectivity Filter Regulates Antiarrhythmic Drug Binding
Sunami, Akihiko, Dudley, Samuel C., Fozzard, Harry A.
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.1997)
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Lidocaine: A Foot in the Door of the Inner Vestibule Prevents Ultra-Slow Inactivation of a Voltage-Gated Sodium Channel
Sandtner, Walter, Szendroedi, Julia, Zarrabi, Touran, Zebedin, Eva, Hilber, Karlheinz, Glaaser, Ian, Fozzard, Harry A, Dudley, Samuel C, Todt, Hannes
Published in Molecular pharmacology (01.09.2004)
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Published in Molecular pharmacology (01.09.2004)
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A Critical Residue for Isoform Difference in Tetrodotoxin Affinity Is a Molecular Determinant of the External Access Path for Local Anesthetics in the Cardiac Sodium Channel
Sunami, Akihiko, Glaaser, Ian W., Fozzard, Harry A.
Published in Proceedings of the National Academy of Sciences - PNAS (29.02.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (29.02.2000)
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Using Lidocaine and Benzocaine to Link Sodium Channel Molecular Conformations to State-Dependent Antiarrhythmic Drug Affinity
Hanck, Dorothy A, Nikitina, Elena, McNulty, Megan M, Fozzard, Harry A, Lipkind, Gregory M, Sheets, Michael F
Published in Circulation research (28.08.2009)
Published in Circulation research (28.08.2009)
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A Molecular Switch between the Outer and the Inner Vestibules of the Voltage-gated Na+ Channel
Zarrabi, Touran, Cervenka, Rene, Sandtner, Walter, Lukacs, Peter, Koenig, Xaver, Hilber, Karlheinz, Mille, Markus, Lipkind, Gregory M., Fozzard, Harry A., Todt, Hannes
Published in The Journal of biological chemistry (10.12.2010)
Published in The Journal of biological chemistry (10.12.2010)
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