Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate
Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Tyler, John W, Wagner, Trixie, Fozard, John R, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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A role for sensory nerves in the late asthmatic response
Raemdonck, Kristof, de Alba, Jorge, Birrell, Mark A, Grace, Megan, Maher, Sarah A, Irvin, Charles G, Fozard, John R, O'Byrne, Paul M, Belvisi, Maria G
Published in Thorax (01.01.2012)
Published in Thorax (01.01.2012)
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MRI of lung parenchyma in rats and mice using a gradient-echo sequence
Beckmann, Nicolau, Tigani, Bruno, Mazzoni, Lazzaro, Fozard, John R.
Published in NMR in biomedicine (01.08.2001)
Published in NMR in biomedicine (01.08.2001)
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Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI
Beckmann, Nicolau, Tigani, Bruno, Sugar, Rosemary, Jackson, Alan D, Jones, Gareth, Mazzoni, Lazzaro, Fozard, John R
Published in American journal of physiology. Lung cellular and molecular physiology (01.07.2002)
Published in American journal of physiology. Lung cellular and molecular physiology (01.07.2002)
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The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist
Baur, François, Beattie, David, Beer, David, Bentley, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard, Ernst, Roland, Fairhurst, Robin A, Faller, Bernard, Farr, David, Keller, Thomas, Fozard, John R, Fullerton, Joe, Garman, Sheila, Hatto, Julia, Hayden, Claire, He, Handan, Howes, Colin, Janus, Diana, Jiang, Zhengjin, Lewis, Christine, Loeuillet-Ritzler, Frederique, Moser, Heinz, Reilly, John, Steward, Alan, Sykes, David, Tedaldi, Lauren, Trifilieff, Alexandre, Tweed, Morris, Watson, Simon, Wissler, Elke, Wyss, Daniel
Published in Journal of medicinal chemistry (13.05.2010)
Published in Journal of medicinal chemistry (13.05.2010)
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Stereoselective Preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a Potent and Orally Active Dual Neurokinin NK1/NK2 Receptor Antagonist
Gerspacher, Marc, Lewis, Christine, Ball, Howard A, Howes, Colin, Subramanian, Natarajan, Ryffel, Karin, Fozard, John R
Published in Journal of medicinal chemistry (31.07.2003)
Published in Journal of medicinal chemistry (31.07.2003)
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An investigation into the structure-activity relationships associated with the systematic modification of the beta(2)-adrenoceptor agonist indacaterol
Beattie, David, Beer, David, Bradley, Michelle E., Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Farr, David, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth M., Sandham, David A., Sykes, David A., Trifilieff, Alexandre, Turner, Katharine L., Wissler, Elke
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol
Beattie, David, Beer, David, Bradley, Michelle E., Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Farr, David, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth M., Sandham, David A., Sykes, David A., Trifilieff, Alexandre, Turner, Katharine L., Wissler, Elke
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog
FOZARD, John R, BAUR, Francois, WOLBER, Cedric
Published in European journal of pharmacology (15.08.2003)
Published in European journal of pharmacology (15.08.2003)
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Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI
Tigani, Bruno, Cannet, Catherine, Karmouty-Quintana, Harry, Ble, Francois-Xavier, Zurbruegg, Stefan, Schaeublin, Elisabeth, Fozard, John R, Beckmann, Nicolau
Published in American journal of physiology. Lung cellular and molecular physiology (01.03.2007)
Published in American journal of physiology. Lung cellular and molecular physiology (01.03.2007)
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Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI
Karmouty-Quintana, Harry, Cannet, Catherine, Zurbruegg, Stefan, Blé, François-Xavier, Fozard, John R., Page, Clive P., Beckmann, Nicolau
Published in Journal of magnetic resonance imaging (01.10.2007)
Published in Journal of magnetic resonance imaging (01.10.2007)
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Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats
Quintana, Harry Karmouty, Cannet, Catherine, Zurbruegg, Stefan, Blé, François-Xavier, Fozard, John R., Page, Clive P., Beckmann, Nicolau
Published in Magnetic resonance in medicine (01.12.2006)
Published in Magnetic resonance in medicine (01.12.2006)
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Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat
Quintana, Harry Karmouty, Cannet, Catherine, Schaeublin, Elisabeth, Zurbruegg, Stefan, Sugar, Rosemary, Mazzoni, Lazzaro, Page, Clive P, Fozard, John R, Beckmann, Nicolau
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2006)
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2006)
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Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists
BEATTIE, David, BREARLEY, Andrew, NANSON, Lana, NEEF, James, OAKMAN, Helen, SPOONER, Gillian, TAYLOR, Roger J, TURNER, Robert J, WEST, Ryan, WOODWARD, Hannah, BROWN, Zarin, CHARLTON, Steven J, COX, Brian, FAIRHURST, Robin A, FOZARD, John R, GEDECK, Peter, KIRKHAM, Paul, MEJA, Koremu
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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