A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial Immunophilins
BEGLEY, Darren W, FOX, David, BARNES, Steve R, MOEN, Spencer O, RAYMOND, Amy C, STACY, Robin, MYLER, Peter J, STAKER, Bart L, HARMER, Nicholas J, NORVILLE, Isobel H, HOLZGRABE, Ulrike, SARKAR-TYSON, Mitali, JENNER, Dominic, EDWARDS, Thomas E, LORIMER, Donald D, JULI, Christina, PIERCE, Phillip G, ABENDROTH, Jan, MURUTHI, Muigai, SAFFORD, Kris, ANDERSON, Vanessa, ATKINS, Kateri
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
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Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer
O'Connell, James, Porter, John, Kroeplien, Boris, Norman, Tim, Rapecki, Stephen, Davis, Rachel, McMillan, David, Arakaki, Tracy, Burgin, Alex, Fox Iii, David, Ceska, Tom, Lecomte, Fabien, Maloney, Alison, Vugler, Alex, Carrington, Bruce, Cossins, Benjamin P, Bourne, Tim, Lawson, Alastair
Published in Nature communications (19.12.2019)
Published in Nature communications (19.12.2019)
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Journal Article
Structural basis for RNA replication by the hepatitis C virus polymerase
Appleby, Todd C., Perry, Jason K., Murakami, Eisuke, Barauskas, Ona, Feng, Joy, Cho, Aesop, Fox, David, Wetmore, Diana R., McGrath, Mary E., Ray, Adrian S., Sofia, Michael J., Swaminathan, S., Edwards, Thomas E.
Published in Science (American Association for the Advancement of Science) (13.02.2015)
Published in Science (American Association for the Advancement of Science) (13.02.2015)
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Journal Article
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
Juvvadi, Praveen R, Fox, 3rd, David, Bobay, Benjamin G, Hoy, Michael J, Gobeil, Sophie M C, Venters, Ronald A, Chang, Zanetta, Lin, Jackie J, Averette, Anna Floyd, Cole, D Christopher, Barrington, Blake C, Wheaton, Joshua D, Ciofani, Maria, Trzoss, Michael, Li, Xiaoming, Lee, Soo Chan, Chen, Ying-Lien, Mutz, Mitchell, Spicer, Leonard D, Schumacher, Maria A, Heitman, Joseph, Steinbach, William J
Published in Nature communications (19.09.2019)
Published in Nature communications (19.09.2019)
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Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation
Xu, Dongyi, Shen, Weiping, Guo, Rong, Xue, Yutong, Peng, Wei, Sima, Jian, Yang, Jay, Sharov, Alexei, Srikantan, Subramanya, Yang, Jiandong, Fox, 3rd, David, Qian, Yong, Martindale, Jennifer L, Piao, Yulan, Machamer, James, Joshi, Samit R, Mohanty, Subhasis, Shaw, Albert C, Lloyd, Thomas E, Brown, Grant W, Ko, Minoru S H, Gorospe, Myriam, Zou, Sige, Wang, Weidong
Published in Nature neuroscience (01.09.2013)
Published in Nature neuroscience (01.09.2013)
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Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR
Stöppler, Daniel, Macpherson, Alex, Smith-Penzel, Susanne, Basse, Nicolas, Lecomte, Fabien, Deboves, Hervé, Taylor, Richard D, Norman, Tim, Porter, John, Waters, Lorna C, Westwood, Marta, Cossins, Ben, Cain, Katharine, White, James, Griffin, Robert, Prosser, Christine, Kelm, Sebastian, Sullivan, Amy H, Fox, 3rd, David, Carr, Mark D, Henry, Alistair, Taylor, Richard, Meier, Beat H, Oschkinat, Hartmut, Lawson, Alastair D
Published in PLoS biology (21.05.2018)
Published in PLoS biology (21.05.2018)
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Journal Article
Discovery of triazines as selective PDE4B versus PDE4D inhibitors
Hagen, Timothy J., Mo, Xuesheng, Burgin, Alex B., Fox, David, Zhang, Zheng, Gurney, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Journal Article
Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication
Xu, Dongyi, Muniandy, Parameswary, Leo, Elisabetta, Yin, Jinhu, Thangavel, Saravanabhavan, Shen, Xi, Ii, Miki, Agama, Keli, Guo, Rong, Fox III, David, Meetei, Amom Ruhikanta, Wilson, Lauren, Nguyen, Huy, Weng, Nan-ping, Brill, Steven J, Li, Lei, Vindigni, Alessandro, Pommier, Yves, Seidman, Michael, Wang, Weidong
Published in The EMBO journal (15.09.2010)
Published in The EMBO journal (15.09.2010)
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Journal Article
Binding and Recognition in the Assembly of an Active BRCA1/BARD1 Ubiquitin-Ligase Complex
Brzovic, Peter S., Keeffe, Jennifer R., Nishikawa, Hiroyuki, Miyamoto, Keiko, Fox, David, Fukuda, Mamoru, Ohta, Tomohiko, Klevit, Rachel
Published in Proceedings of the National Academy of Sciences - PNAS (13.05.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (13.05.2003)
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A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network
Yan, Zhijiang, Guo, Rong, Paramasivam, Manikandan, Shen, Weiping, Ling, Chen, Fox, David, Wang, Yucai, Oostra, Anneke B., Kuehl, Julia, Lee, Duck-Yeon, Takata, Minoru, Hoatlin, Maureen E., Schindler, Detlev, Joenje, Hans, de Winter, Johan P., Li, Lei, Seidman, Michael M., Wang, Weidong
Published in Molecular cell (13.07.2012)
Published in Molecular cell (13.07.2012)
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Identification and Structural Determination of the M sub(3) Muscarinic Acetylcholine Receptor Basolateral Sorting Signal
Iverson, Heidi A, Fox, David III, Nadler, Laurie S, Klevit, Rachel E, Nathanson, Neil M
Published in The Journal of biological chemistry (01.07.2005)
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Published in The Journal of biological chemistry (01.07.2005)
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