Arrhythmogenic late Ca2+ sparks in failing heart cells and their control by action potential configuration
Fowler, Ewan D., Wang, Nan, Hezzell, Melanie, Chanoit, Guillaume, Hancox, Jules C., Cannell, Mark B.
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2020)
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Journal Article
Improved Ca2+ release synchrony following selective modification of Itof and phase 1 repolarization in normal and failing ventricular myocytes
Fowler, Ewan D., Wang, Nan, Hezzell, Melanie J., Chanoit, Guillaume, Hancox, Jules C., Cannell, Mark B.
Published in Journal of molecular and cellular cardiology (01.11.2022)
Published in Journal of molecular and cellular cardiology (01.11.2022)
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Journal Article
Inducing Ito,f and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene
Wang, Nan, Dries, Eef, Fowler, Ewan D., Harmer, Stephen C., Hancox, Jules C., Cannell, Mark B.
Published in Journal of molecular and cellular cardiology (01.03.2022)
Published in Journal of molecular and cellular cardiology (01.03.2022)
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Journal Article
Energy Metabolism in the Failing Right Ventricle: Limitations of Oxygen Delivery and the Creatine Kinase System
Fowler, Ewan D, Hauton, David, Boyle, John, Egginton, Stuart, Steele, Derek S, White, Ed
Published in International journal of molecular sciences (12.04.2019)
Published in International journal of molecular sciences (12.04.2019)
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Journal Article
Beta1-adrenoceptor antagonist, metoprolol attenuates cardiac myocyte Ca2+ handling dysfunction in rats with pulmonary artery hypertension
Fowler, Ewan D., Drinkhill, Mark J., Norman, Ruth, Pervolaraki, Eleftheria, Stones, Rachel, Steer, Emma, Benoist, David, Steele, Derek S., Calaghan, Sarah C., White, Ed
Published in Journal of molecular and cellular cardiology (01.07.2018)
Published in Journal of molecular and cellular cardiology (01.07.2018)
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Journal Article
Arrhythmogenic late Ca 2+ sparks in failing heart cells and their control by action potential configuration
Fowler, Ewan D, Wang, Nan, Hezzell, Melanie, Chanoit, Guillaume, Hancox, Jules C, Cannell, Mark B
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2020)
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Journal Article
Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness
Sequeira, Vasco, Najafi, Aref, McConnell, Mark, Fowler, Ewan D, Bollen, Ilse A E, Wüst, Rob C I, dos Remedios, Cris, Helmes, Michiel, White, Ed, Stienen, Ger J M, Tardiff, Jil, Kuster, Diederik W D, van der Velden, Jolanda
Published in The Journal of physiology (01.09.2015)
Published in The Journal of physiology (01.09.2015)
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Journal Article
Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness
Sequeira, Vasco, Najafi, Aref, McConnell, Mark, Fowler, Ewan D., Bollen, Ilse A. E., Wüst, Rob C. I., dos Remedios, Cris, Helmes, Michiel, White, Ed, Stienen, Ger J. M., Tardiff, Jil, Kuster, Diederik W. D., der Velden, Jolanda
Published in The Journal of physiology (01.09.2015)
Published in The Journal of physiology (01.09.2015)
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Journal Article
Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells
Fowler, Ewan D, Kong, Cherrie H.T, Hancox, Jules C, Cannell, Mark B
Published in Circulation research (02.02.2018)
Published in Circulation research (02.02.2018)
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Journal Article
Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease
Fowler, Ewan Douglas, Zissimopoulos, Spyros
Published in Biomolecules (Basel, Switzerland) (26.07.2022)
Published in Biomolecules (Basel, Switzerland) (26.07.2022)
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Journal Article
Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension
Fowler, Ewan D, Benoist, David, Drinkhill, Mark J, Stones, Rachel, Helmes, Michiel, Wüst, Rob C.I, Stienen, Ger J.M, Steele, Derek S, White, Ed
Published in Journal of molecular and cellular cardiology (01.09.2015)
Published in Journal of molecular and cellular cardiology (01.09.2015)
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Journal Article
Late Ca 2+ Sparks and Ripples During the Systolic Ca 2+ Transient in Heart Muscle Cells
Fowler, Ewan D, Kong, Cherrie H T, Hancox, Jules C, Cannell, Mark B
Published in Circulation research (02.02.2018)
Published in Circulation research (02.02.2018)
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Journal Article
A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development
Diggle, Christine P, Martinez-Garay, Isabel, Molnar, Zoltan, Brinkworth, Martin H, White, Ed, Fowler, Ewan, Hughes, Ruth, Hayward, Bruce E, Carr, Ian M, Watson, Christopher M, Crinnion, Laura, Asipu, Aruna, Woodman, Ben, Coletta, P Louise, Markham, Alexander F, Dear, T Neil, Bonthron, David T, Peckham, Michelle, Morrison, Ewan E, Sheridan, Eamonn
Published in PloS one (07.04.2017)
Published in PloS one (07.04.2017)
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Journal Article
Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline
Benoist, David, Stones, Rachel, Benson, Alan P., Fowler, Ewan D., Drinkhill, Mark J., Hardy, Matthew E.L., Saint, David A., Cazorla, Olivier, Bernus, Olivier, White, Ed
Published in Progress in biophysics and molecular biology (01.08.2014)
Published in Progress in biophysics and molecular biology (01.08.2014)
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Journal Article
Editorial: Stretch and the heart: mechanoelectrical coupling and arrhythmias
Fowler, Ewan Douglas, Azarov, Jan E., Brette, Fabien
Published in Frontiers in physiology (25.08.2023)
Published in Frontiers in physiology (25.08.2023)
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Journal Article
Shaping Action Potential Repolarization Phase I by Stoichiometric Expression of Kv4.3/KChIP2.1
Wang, Nan, Dries, Eef, Fowler, Ewan D., Hancox, Jules C., Cannell, Mark B.
Published in Biophysical journal (07.02.2020)
Published in Biophysical journal (07.02.2020)
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Journal Article
Late Ca2+Spark Arrhythmogenesis in Failing Cardiac Myocytes
Fowler, Ewan D., Wang, Nan, Hancox, Jules C., Cannell, Mark B.
Published in Biophysical journal (07.02.2020)
Published in Biophysical journal (07.02.2020)
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Journal Article
Metoprolol Reverses β-Adrenergic Remodeling in the Failing Right Ventricle of Pulmonary Artery Hypertensive (PAH) Rats
Norman, Ruth, Fowler, Ewan, White, Ed, Calaghan, Sarah
Published in Biophysical journal (16.02.2016)
Published in Biophysical journal (16.02.2016)
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Journal Article