Phosphinic Derivatives as New Dual Enkephalin-Degrading Enzyme Inhibitors: Synthesis, Biological Properties, and Antinociceptive Activities
Chen, Huixiong, Noble, Florence, Mothé, Aurélie, Meudal, Hervé, Coric, Pascale, Danascimento, Sophie, Roques, Bernard P, George, Pascal, Fournié-Zaluski, Marie-Claude
Published in Journal of medicinal chemistry (06.04.2000)
Published in Journal of medicinal chemistry (06.04.2000)
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Viral RNA Annealing Activities of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein Require Only Peptide Domains Outside the Zinc Fingers
De Rocquigny, Hughes, Gabus, Caroline, Vincent, Anne, Fournie-Zaluski, Marie-Claude, Roques, Bernard, Darlix, Jean-Luc
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.1992)
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.1992)
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First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [ 125I]RB 129
Noble, F, Banisadr, G, Jardinaud, F, Popovici, T, Lai-Kuen, R, Chen, H, Bischoff, L, Parsadaniantz, S.Melik, Fournie-Zaluski, M.-C, Roques, B.P
Published in Neuroscience (01.01.2001)
Published in Neuroscience (01.01.2001)
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A Mimic of HIV-1 Nucleocapsid Protein Impairs Reverse Transcription and Displays Antiviral Activity
Druillennec, S., Dong, C. Z., Escaich, S., Gresh, N., Bousseau, A., Roques, B. P., Fournié-Zaluski, M. C.
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.1999)
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Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure
Reaux, A, Iturrioz, X, Vazeux, G, Fournie-Zaluski, M C, David, C, Roques, B P, Corvol, P, Llorens-Cortes, C
Published in Biochemical Society transactions (01.08.2000)
Published in Biochemical Society transactions (01.08.2000)
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Dual Inhibition of Angiotensin-Converting Enzyme and Neutral Endopeptidase by the Orally Active Inhibitor Mixanpril: A Potential Therapeutic Approach in Hypertension
Fournie-Zaluski, M. C., Gonzalez, W., Turcaud, S., Pham, I., Roques, B. P., Michel, J. B.
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.1994)
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Identification of Metabolic Pathways of Brain Angiotensin II and III Using Specific Aminopeptidase Inhibitors: Predominant Role of Angiotensin III in the Control of Vasopressin Release
Zini, Sylvie, Fournie-Zaluski, Marie-Claude, Chauvel, Eric, Roques, Bernard P., Corvol, Pierre, Llorens-Cortes, Catherine
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.1996)
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Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats
F Noble, J M Soleilhac, E Soroca-Lucas, S Turcaud, M C Fournie-Zaluski, B P Roques
Published in The Journal of pharmacology and experimental therapeutics (01.04.1992)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1992)
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Brain Renin-Angiotensin System Blockade by Systemically Active Aminopeptidase A Inhibitors: A Potential Treatment of Salt-Dependent Hypertension
Fournie-Zaluski, Marie-Claude, Fassot, Celine, Valentin, Bruno, Djordjijevic, Dragan, Goazigo, Annabelle Reaux-Le, Corvol, Pierre, Roques, Bernard P., Llorens-Cortes, Catherine, Baulieu, Etienne-Emile
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2004)
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Autoradiographic Comparison of the Distribution of the Neutral Endopeptidase ``Enkephalinase'' and of μ and δ Opioid Receptors in Rat Brain
Waksman, Gilles, Hamel, Edith, Fournié-Zaluski, Marie-Claude, Roques, Bernard P.
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.1986)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.1986)
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Model of the complex formed between the H2 domain of the TATA box binding protein and the L(281-301) fragment of the human transcription factor TFIIA
Ramboarina, S, Morellet, N, Petitjean, P, Roques, B P, Fournié-Zaluski, M C
Published in Protein engineering (01.09.1998)
Published in Protein engineering (01.09.1998)
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The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by β-funaltrexamine, a selective μ-opioid receptor antagonist
Le Guen, Stéphanie, Honoré, Prisca, Catheline, Gwénaëlle, Fournié-Zaluski, Marie-Claude, Roques, Bernard-Pierre, Besson, Jean-Marie
Published in Brain research (10.07.1999)
Published in Brain research (10.07.1999)
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Stimulation of delta-opioid receptors reduces the in vivo binding of the cholecystokinin (CCK)-B-selective agonist [3H]pBC 264: evidence for a physiological regulation of CCKergic systems by endogenous enkephalins
Ruiz-Gayo, M, Durieux, C, Fournié-Zaluski, M C, Roques, B P
Published in Journal of neurochemistry (01.11.1992)
Published in Journal of neurochemistry (01.11.1992)
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Acute effect of the dual angiotensin‐converting enzyme and neutral endopeptidase 24‐11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat
Arbin, V, Claperon, N, Fournié‐Zaluski, M ‐C, Roques, B P, Peyroux, J
Published in British journal of pharmacology (01.06.2001)
Published in British journal of pharmacology (01.06.2001)
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Journal Article
Effect of endopeptidase‐24.11 inhibitors and C‐ANP receptor ligand on responses evoked in arterioles of rat cremaster muscle by atrial natriuretic peptide
Peyroux, J., Beslot, F., Claperon, N., Fournie‐Zaluski, M‐C., Roques, B.P.
Published in British journal of pharmacology (01.12.1995)
Published in British journal of pharmacology (01.12.1995)
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Development of [125I]RB104, a Potent Inhibitor of Neutral Endopeptidase 24.11, and its Use in Detecting Nanogram Quantities of the Enzyme by "Inhibitor Gel Electrophoresis"
Fournie-Zaluski, M. C., Soleihac, J. M., Turcaud, S., Lai-Kuen, R., Crine, P., Beaumont, A., Roques, B. P.
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.1992)
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.1992)
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Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats
Zini, S, Masdehors, P, Lenkei, Z, Fournie-Zaluski, M.-C, Roques, B.P, Corvol, P, Llorens-Cortes, C
Published in Neuroscience (01.06.1997)
Published in Neuroscience (01.06.1997)
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Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord
BOURGOIN, S, LE BARS, D, ARTAUD, F, CLOT, A.-M, BOUBOUTOU, R, FOURNIE-ZALUSKI, M.-C, ROQUES, B. P, HAMON, M, CESSELIN, F
Published in The Journal of pharmacology and experimental therapeutics (01.07.1986)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1986)
Journal Article
Aminophosphinic Inhibitors as Transition State Analogues of Enkephalin-Degrading Enzymes: A Class of Central Analgesics
Chen, Huixiong, Noble, Florence, Coric, Pascale, Fournie-Zaluski, Marie-Claude, Roques, Bernard P.
Published in Proceedings of the National Academy of Sciences - PNAS (29.09.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (29.09.1998)
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