A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome
Liddle, John, Beneton, Veronique, Benson, Matthew, Bingham, Ryan, Bouillot, Anne, Boullay, Anne-Benedicte, Brook, Eloisa, Cryan, Jenni, Denis, Alexis, Edgar, Emma, Ferrie, Alan, Fouchet, Marie-Helene, Grillot, Didier, Holmes, Duncan S., Howes, Ashleigh, Krysa, Gael, Laroze, Alain, Lennon, Mark, McClure, Fiona, Moquette, Alexandre, Nicodeme, Edwige, Santiago, Brandon, Santos, Leandro, Smith, Kathrine J., Thorpe, James H., Thripp, Gary, Trottet, Lionel, Walker, Ann L., Ward, Simon A., Wang, Yichen, Wilson, Steve, Pearce, Andrew C., Hovnanian, Alain
Published in Journal of investigative dermatology (01.09.2021)
Published in Journal of investigative dermatology (01.09.2021)
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Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors
Walker, Ann L., Denis, Alexis, Bingham, Ryan P., Bouillot, Anne, Edgar, Emma V., Ferrie, Alan, Holmes, Duncan S., Laroze, Alain, Liddle, John, Fouchet, Marie-Helene, Moquette, Alexandre, Nassau, Pam, Pearce, Andrew C., Polyakova, Oxana, Smith, Kathrine J., Thomas, Pamela, Thorpe, James H., Trottet, Lionel, Wang, Yichen, Hovnanian, Alain
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits
Bertrand, Sophie M, Ancellin, Nicolas, Beaufils, Benjamin, Bingham, Ryan P, Borthwick, Jennifer A, Boullay, Anne-Bénédicte, Boursier, Eric, Carter, Paul S, Chung, Chun-wa, Churcher, Ian, Dodic, Nerina, Fouchet, Marie-Hélène, Fournier, Charlène, Francis, Peter L, Gummer, Laura A, Herry, Kenny, Hobbs, Andrew, Hobbs, Clare I, Homes, Paul, Jamieson, Craig, Nicodeme, Edwige, Pickett, Stephen D, Reid, Iain H, Simpson, Graham L, Sloan, Lisa A, Smith, Sarah E, Somers, Donald O’N, Spitzfaden, Claus, Suckling, Colin J, Valko, Klara, Washio, Yoshiaki, Young, Robert J
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPAR gamma agonists
Lamotte, Yann, Faucher, Nicolas, Sancon, Julien, Pineau, Olivier, Sautet, Stephane, Fouchet, Marie-Helene, Beneton, Veronique, Tousaint, Jean-Jacques, Saintillan, Yannick, Ancellin, Nicolas, Nicodeme, Edwige, Grillot, Didier, Martres, Paul
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
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Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPARα Agonists. 1. Discovery of a Novel Series of Potent HDLc Raising Agents
Sierra, Michael L, Beneton, Véronique, Boullay, Anne-Bénédict, Boyer, Thierry, Brewster, Andrew G, Donche, Frédéric, Forest, Marie-Claire, Fouchet, Marie-Hélène, Gellibert, Françoise J, Grillot, Didier A, Lambert, Millard H, Laroze, Alain, Le Grumelec, Christelle, Linget, Jean Michel, Montana, Valerie G, Nguyen, Van-Loc, Nicodème, Edwige, Patel, Vipul, Penfornis, Annie, Pineau, Olivier, Pohin, Danig, Potvain, Florent, Poulain, Géraldine, Ruault, Cécile Bertho, Saunders, Michael, Toum, Jérôme, Xu, H. Eric, Xu, Robert X, Pianetti, Pascal M
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase
Harris, Philip A, Faucher, Nicolas, George, Nicolas, Eidam, Patrick M, King, Bryan W, White, Gemma V, Anderson, Niall A, Bandyopadhyay, Deepak, Beal, Allison M, Beneton, Veronique, Berger, Scott B, Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A, Cox, Julie A, Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N, Geddes, Brad, Gough, Peter J, Grondin, Pascal, Hoffman, Bonnie L, Hoffman, Sandra J, Hutchinson, Susan E, Jeong, Jae U, Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K, Lich, John D, Mahajan, Mukesh K, Meslamani, Jamel, Mosley, Julie E, Nagilla, Rakesh, Nassau, Pamela M, Ng, Sze-Ling, Ouellette, Michael T, Pasikanti, Kishore K, Potvain, Florent, Reilly, Michael A, Rivera, Elizabeth J, Sautet, Stéphane, Schaeffer, Michelle C, Sehon, Clark A, Sun, Helen, Thorpe, James H, Totoritis, Rachel D, Ward, Paris, Wellaway, Natalie, Wisnoski, David D, Woolven, James M, Bertin, John, Marquis, Robert W
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
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Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity
Fouchet, Marie-Hélène, Donche, Frédéric, Martin, Christelle, Bouillot, Anne, Junot, Christophe, Boullay, Anne-Bénédicte, Potvain, Florent, Magny, Sylvie Demaria, Coste, Hervé, Walker, Max, Issandou, Marc, Dodic, Nérina
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors
Gellibert, Françoise, Woolven, James, Fouchet, Marie-Hélène, Mathews, Neil, Goodland, Helen, Lovegrove, Victoria, Laroze, Alain, Nguyen, Van-Loc, Sautet, Stéphane, Wang, Ruolan, Janson, Cheryl, Smith, Ward, Krysa, Gaël, Boullay, Valérie, de Gouville, Anne-Charlotte, Huet, Stéphane, Hartley, David
Published in Journal of medicinal chemistry (26.08.2004)
Published in Journal of medicinal chemistry (26.08.2004)
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Corrigendum to ‘Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors’ [Bioorg. Med. Chem. Lett. 29 (2019) 126675]
Walker, Ann L., Denis, Alexis, Bingham, Ryan P., Bouillot, Anne, Edgar, Emma V., Ferrie, Alan, Holmes, Duncan S., Laroze, Alain, Liddle, John, Fouchet, Marie-Helene, Moquette, Alexandre, Nassau, Pam, Pearce, Andrew C., Polyakova, Oxana, Smith, Kathrine J., Thomas, Pamela, Thorpe, James H., Trottet, Lionel, Wang, Yichen, Hovnanian, Alain
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
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Abstract 1398: Structure-based design of small macrocyclic CDK9 degraders as chemical biology tools and beyond
Dodic, Nerina, Ancellin, Nicolas, Bordessoules, Morgane, Bouillot, Anne, Butin, Nathan, Charrier, Cedric, Fouchet, Marie-Helene, Laroze, Alain, Luzy, Anne-Pascale, Moquette, Alexandre, Pilot, Julia, Serin, Guillaume, Mirjolet, Jean-François, Viviani, Fabrice, Parsy, Christophe
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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The discovery of equipotent PPARα/γ dual activators
MARTRES, Paul, FAUCHER, Nicolas, LAROZE, Alain, PINEAU, Olivier, FOUCHET, Marie Helene, POTVAIN, Florent, GRILLOT, Didier, BENETON, Veronique
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Model of the Second Most Abundant Cisplatin−DNA Cross-Link: X-ray Crystal Structure and Conformational Analysis of cis-[(NH3)2Pt(9-MeA-N7)(9-EtGH-N7)](NO3)·2H2O (9-MeA = 9-Methyladenine; 9-EtGH = 9-Ethylguanine)
Schröder, Guy, Kozelka, Jirí, Sabat, Michal, Fouchet, Marie-Hélène, Beyerle-Pfnür, Rut, Lippert, Bernhard
Published in Inorganic chemistry (13.03.1996)
Published in Inorganic chemistry (13.03.1996)
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Structure of a nonanucleotide duplex cross-linked by cisplatin at an ApG sequence
Fouchet, Marie-Hélène, Guittet, Eric, Cognet, Jean A. H., Kozelka, Jiří, Gauthier, Corinne, Bret, Marc Le, Zimmermann, Karel, Chottard, Jean-Claude
Published in Journal of biological inorganic chemistry (01.02.1997)
Published in Journal of biological inorganic chemistry (01.02.1997)
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Year of Publication 17.03.2022
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GEORGE, NICOLAS, BOUIX-PETER, CLAIRE, HARRIS, CRAIG, FOUCHET, MARIE-HELENE, OUVRY, GILLES, MUSICKI, BRANISLAV
Year of Publication 16.07.2022
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OUVRY, Gilles, MUSICKI, Branislav, GEORGE, Nicolas, FOUCHET, Marie-Hélène, HARRIS, Craig, BOUIX-PETER, Claire
Year of Publication 24.10.2024
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Year of Publication 24.10.2024
Patent
NOVEL JAK INHIBITOR COMPOUNDS, METHOD FOR SYNTHESIZING SAME AND USE THEREOF
OUVRY, Gilles, MUSICKI, Branislav, GEORGE, Nicolas, FOUCHET, Marie-Hélène, HARRIS, Craig, BOUIX-PETER, Claire
Year of Publication 25.07.2024
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Year of Publication 25.07.2024
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