Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae
Fossati, Elena, Ekins, Andrew, Narcross, Lauren, Zhu, Yun, Falgueyret, Jean-Pierre, Beaudoin, Guillaume A W, Facchini, Peter J, Martin, Vincent J J
Published in Nature communications (2014)
Published in Nature communications (2014)
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Journal Article
Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae
Fossati, Elena, Narcross, Lauren, Ekins, Andrew, Falgueyret, Jean-Pierre, Martin, Vincent J J
Published in PloS one (23.04.2015)
Published in PloS one (23.04.2015)
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Journal Article
Microbial Factories for the Production of Benzylisoquinoline Alkaloids
Narcross, Lauren, Fossati, Elena, Bourgeois, Leanne, Dueber, John E, Martin, Vincent J.J
Published in Trends in biotechnology (Regular ed.) (01.03.2016)
Published in Trends in biotechnology (Regular ed.) (01.03.2016)
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Journal Article
Characterization of a Flavoprotein Oxidase from Opium Poppy Catalyzing the Final Steps in Sanguinarine and Papaverine Biosynthesis
Hagel, Jillian M., Beaudoin, Guillaume A.W., Fossati, Elena, Ekins, Andrew, Martin, Vincent J.J., Facchini, Peter J.
Published in The Journal of biological chemistry (14.12.2012)
Published in The Journal of biological chemistry (14.12.2012)
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Journal Article
Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance
Volpato, Jordan P., Yachnin, Brahm J., Blanchet, Jonathan, Guerrero, Vanessa, Poulin, Lucie, Fossati, Elena, Berghuis, Albert M., Pelletier, Joelle N.
Published in The Journal of biological chemistry (24.07.2009)
Published in The Journal of biological chemistry (24.07.2009)
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Journal Article
Exploitation of the alcohol dehydrogenase-acetone NADP-regeneration system for the enzymatic preparative-scale production of 12-ketochenodeoxycholic acid
Fossati, Elena, Polentini, Fausto, Carrea, Giacomo, Riva, Sergio
Published in Biotechnology and bioengineering (20.04.2006)
Published in Biotechnology and bioengineering (20.04.2006)
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Journal Article
A Combinatorial Approach To Study Cytochrome P450 Enzymes for De Novo Production of Steviol Glucosides in Baker’s Yeast
Gold, Nicholas D, Fossati, Elena, Hansen, Cecilie Cetti, DiFalco, Marcos, Douchin, Veronique, Martin, Vincent J. J
Published in ACS synthetic biology (21.12.2018)
Published in ACS synthetic biology (21.12.2018)
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Journal Article
Mining Enzyme Diversity of Transcriptome Libraries through DNA Synthesis for Benzylisoquinoline Alkaloid Pathway Optimization in Yeast
Narcross, Lauren, Bourgeois, Leanne, Fossati, Elena, Burton, Euan, Martin, Vincent J. J
Published in ACS synthetic biology (16.12.2016)
Published in ACS synthetic biology (16.12.2016)
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Journal Article
Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells
Volpato, Jordan P., Mayotte, Nadine, Fossati, Elena, Guerrero, Vanessa, Sauvageau, Guy, Pelletier, Joelle N.
Published in Journal of molecular recognition (01.03.2011)
Published in Journal of molecular recognition (01.03.2011)
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Journal Article
Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae: e0124459
Fossati, Elena, Narcross, Lauren, Ekins, Andrew, Falgueyret, Jean-Pierre, Martin, Vincent JJ
Published in PloS one (01.04.2015)
Published in PloS one (01.04.2015)
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Journal Article
2-tier bacterial and in vitro selection of active and methotrexate-resistant variants of human dihydrofolate reductase
Fossati, Elena, Volpato, Jordan P, Poulin, Lucie, Guerrero, Vanessa, Dugas, David-Antoine, Pelletier, Joelle N
Published in Journal of biomolecular screening (01.07.2008)
Published in Journal of biomolecular screening (01.07.2008)
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Journal Article
METHOD OF MAKING A BENZYLISOQUINOLINE ALKALOID (BIA) METABOLITE, ENZYMES THEREFORE
ZHU YUN, NARCROSS LAUREN, FOSSATI ELENA, EKINS ANDREW, MARTIN VINCENT
Year of Publication 24.11.2016
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Year of Publication 24.11.2016
Patent
METHOD OF MAKING A BENZYLISOQUINOLINE ALKALOID (BIA) METABOLITE, ENZYMES THEREFORE
FOSSATI, ELENA, MARTIN, VINCENT, ZHU, YUN, EKINS, ANDREW, NARCROSS, LAUREN
Year of Publication 16.07.2015
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Year of Publication 16.07.2015
Patent
THEBAINE 6-O-DEMETHYLASE AND CODEINE O-DEMETHYLASE FROM PAPAVER SOMNIFERUM
FOSSATI, ELENA, LAUZON, JEAN-FRANCOIS, MARTIN, VINCENT, FARROW, SCOTT, EKINS, ANDREW, FACCHINI, PETER, HAGEL, JILLIAN
Year of Publication 14.07.2011
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Year of Publication 14.07.2011
Patent
THEBAINE 6-O-DEMETHYLASE AND CODEINE O-DEMETHYLASE FROM PAPAVER SOMNIFERUM
FOSSATI, ELENA, LAUZON, JEAN-FRANCOIS, MARTIN, VINCENT, FARROW, SCOTT, EKINS, ANDREW, FACCHINI, PETER, HAGEL, JILLIAN
Year of Publication 19.05.2011
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Year of Publication 19.05.2011
Patent