Proteoglycan degradation by the ADAMTS family of proteinases
Stanton, Heather, Melrose, James, Little, Christopher B., Fosang, Amanda J.
Published in Biochimica et biophysica acta (01.12.2011)
Published in Biochimica et biophysica acta (01.12.2011)
Get full text
Journal Article
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
Stickens, Dominique, Behonick, Danielle J, Ortega, Nathalie, Heyer, Babette, Hartenstein, Bettina, Yu, Ying, Fosang, Amanda J, Schorpp-Kistner, Marina, Angel, Peter, Werb, Zena
Published in Development (Cambridge) (01.12.2004)
Published in Development (Cambridge) (01.12.2004)
Get full text
Journal Article
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Golub, Suzanne B, Rogerson, Fraser M, Campbell, Ian K, East, Charlotte J, Lawlor, Kate E, Little, Christopher B, Fourie, Anne M, Fosang, Amanda J, Meeker, Clare T, Last, Karena, Stanton, Heather, Farmer, Pamela J
Published in Nature (31.03.2005)
Published in Nature (31.03.2005)
Get full text
Journal Article
Transcriptomics of Wild‐Type Mice and Mice Lacking ADAMTS‐5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction
Bateman, John F., Rowley, Lynn, Belluoccio, Daniele, Chan, Ben, Bell, Katrina, Fosang, Amanda J., Little, Christopher B.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2013)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2013)
Get full text
Journal Article
Drug Insight: aggrecanases as therapeutic targets for osteoarthritis
Fosang, Amanda J, Little, Christopher B
Published in Nature clinical practice. Rheumatology (01.08.2008)
Published in Nature clinical practice. Rheumatology (01.08.2008)
Get full text
Journal Article
ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5
Rogerson, Fraser M, Last, Karena, Golub, Suzanne B, Gauci, Stephanie J, Stanton, Heather, Bell, Katrina M, Fosang, Amanda J
Published in International journal of molecular sciences (29.01.2019)
Published in International journal of molecular sciences (29.01.2019)
Get full text
Journal Article
Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
Little, Christopher B, Meeker, Clare T, Golub, Suzanne B, Lawlor, Kate E, Farmer, Pamela J, Smith, Susan M, Fosang, Amanda J
Published in The Journal of clinical investigation (01.06.2007)
Published in The Journal of clinical investigation (01.06.2007)
Get full text
Journal Article
Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung
McDougall, Annie R A, Fosang, Amanda J, Faggian, Jessica, Wallace, Megan J, Crossley, Kelly J, Cole, Timothy J, Hooper, Stuart B
Published in Respiratory research (20.08.2018)
Published in Respiratory research (20.08.2018)
Get full text
Journal Article
Internalization of Aggrecan G1 Domain Neoepitope ITEGE in Chondrocytes Requires CD44
Ariyoshi, Wataru, Knudson, Cheryl B., Luo, Na, Fosang, Amanda J., Knudson, Warren
Published in The Journal of biological chemistry (12.11.2010)
Published in The Journal of biological chemistry (12.11.2010)
Get full text
Journal Article
ADAMTS-5 Deficiency Does Not Block Aggrecanolysis at Preferred Cleavage Sites in the Chondroitin Sulfate-rich Region of Aggrecan
East, Charlotte J., Stanton, Heather, Golub, Suzanne B., Rogerson, Fraser M., Fosang, Amanda J.
Published in The Journal of biological chemistry (23.03.2007)
Published in The Journal of biological chemistry (23.03.2007)
Get full text
Journal Article
Emerging Frontiers in cartilage and chondrocyte biology
Fosang, Amanda J, Beier, Frank
Published in Best practice & research. Clinical rheumatology (01.12.2011)
Published in Best practice & research. Clinical rheumatology (01.12.2011)
Get full text
Journal Article
Distinguishing Aggrecan Loss from Aggrecan Proteolysis in ADAMTS-4 and ADAMTS-5 Single and Double Deficient Mice
Ilic, Mirna Z., East, Charlotte J., Rogerson, Fraser M., Fosang, Amanda J., Handley, Christopher J.
Published in The Journal of biological chemistry (28.12.2007)
Published in The Journal of biological chemistry (28.12.2007)
Get full text
Journal Article
Brief Report: JNK‐2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis
Ismail, Heba M., Miotla‐Zarebska, Jadwiga, Troeberg, Linda, Tang, Xiaodi, Stott, Bryony, Yamamoto, Kazuhiro, Nagase, Hideaki, Fosang, Amanda J., Vincent, Tonia L., Saklatvala, Jeremy
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2016)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2016)
Get full text
Journal Article
ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain
Westling, Jennifer, Fosang, Amanda J., Last, Karena, Thompson, Vivian P., Tomkinson, Kathy N., Hebert, Tracy, McDonagh, Thomas, Collins-Racie, Lisa A., LaVallie, Edward R., Morris, Elisabeth A., Sandy, John D.
Published in The Journal of biological chemistry (03.05.2002)
Published in The Journal of biological chemistry (03.05.2002)
Get full text
Journal Article
Matrix Metalloproteinases Are Not Essential for Aggrecan Turnover during Normal Skeletal Growth and Development
Little, Christopher B., Meeker, Clare T., Hembry, Rosalind M., Sims, Natalie A., Lawlor, Kate E., Golub, Sue B., Last, Karena, Fosang, Amanda J.
Published in Molecular and Cellular Biology (01.04.2005)
Published in Molecular and Cellular Biology (01.04.2005)
Get full text
Journal Article
An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2
Miller, Rachel E, Ishihara, Shingo, Tran, Phuong B, Golub, Suzanne B, Last, Karena, Miller, Richard J, Fosang, Amanda J, Malfait, Anne-Marie
Published in JCI insight (22.03.2018)
Published in JCI insight (22.03.2018)
Get full text
Journal Article
Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse
Azadi, Mojtaba, Nia, Hadi Tavakoli, Gauci, Stephanie J, Ortiz, Christine, Fosang, Amanda J, Grodzinsky, Alan J
Published in Journal of biomechanics (14.06.2016)
Published in Journal of biomechanics (14.06.2016)
Get full text
Journal Article