Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Garcia Fortanet, Jorge, Chen, Christine Hiu-Tung, Chen, Ying-Nan P, Chen, Zhouliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal D, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, LaBonte, Laura R, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Sellers, William R, Shultz, Michael D, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah L, Zhang, Ji-Hu, LaMarche, Matthew J
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2
LaRochelle, Jonathan R, Fodor, Michelle, Xu, Xiang, Durzynska, Izabela, Fan, Lixin, Stams, Travis, Chan, Ho Man, LaMarche, Matthew J, Chopra, Rajiv, Wang, Ping, Fortin, Pascal D, Acker, Michael G, Blacklow, Stephen C
Published in Biochemistry (Easton) (19.04.2016)
Published in Biochemistry (Easton) (19.04.2016)
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Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor
Shultz, Michael D, Cheung, Atwood K, Kirby, Christina A, Firestone, Brant, Fan, Jianmei, Chen, Christine Hiu-Tung, Chen, Zhouliang, Chin, Donovan N, DiPietro, Lucian, Fazal, Aleem, Feng, Yun, Fortin, Pascal D, Gould, Ty, Lagu, Bharat, Lei, Huangshu, Lenoir, Francois, Majumdar, Dyuti, Ochala, Etienne, Palermo, M. G, Pham, Ly, Pu, Minying, Smith, Troy, Stams, Travis, Tomlinson, Ronald C, Touré, B. Barry, Visser, Michael, Wang, Run Ming, Waters, Nigel J, Shao, Wenlin
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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β-Hydroxylation of the Aspartyl Residue in the Phytotoxin Syringomycin E: Characterization of Two Candidate Hydroxylases AspH and SyrP in Pseudomonas syringae
Singh, Gitanjali M, Fortin, Pascal D, Koglin, Alexander, Walsh, Christopher T
Published in Biochemistry (Easton) (28.10.2008)
Published in Biochemistry (Easton) (28.10.2008)
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Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia
Varkaris, Andreas, Pazolli, Ermira, Gunaydin, Hakan, Wang, Qi, Pierce, Levi, Boezio, Alessandro A, Bulku, Artemisa, DiPietro, Lucian, Fridrich, Cary, Frost, Adam, Giordanetto, Fabrizio, Hamilton, Erika P, Harris, Katherine, Holliday, Michael, Hunter, Tamieka L, Iskandar, Amanda, Ji, Yongli, Larivée, Alexandre, LaRochelle, Jonathan R, Lescarbeau, André, Llambi, Fabien, Lormil, Brenda, Mader, Mary M, Mar, Brenton G, Martin, Iain, McLean, Thomas H, Michelsen, Klaus, Pechersky, Yakov, Puente-Poushnejad, Erika, Raynor, Kevin, Rogala, Dipali, Samadani, Ramin, Schram, Alison M, Shortsleeves, Kelley, Swaminathan, Sweta, Tajmir, Shahein, Tan, Gege, Tang, Yong, Valverde, Roberto, Wehrenberg, Bryan, Wilbur, Jeremy, Williams, Bret R, Zeng, Hongtao, Zhang, Hanmo, Walters, W Patrick, Wolf, Beni B, Shaw, David E, Bergstrom, Donald A, Watters, James, Fraser, James S, Fortin, Pascal D, Kipp, D Randal
Published in Cancer discovery (08.02.2024)
Published in Cancer discovery (08.02.2024)
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[1,2,4]Triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: Antagonists of the Wnt Pathway That Inhibit Tankyrases 1 and 2 via Novel Adenosine Pocket Binding
Shultz, Michael D, Kirby, Christina A, Stams, Travis, Chin, Donovan N, Blank, Jutta, Charlat, Olga, Cheng, Hong, Cheung, Atwood, Cong, Feng, Feng, Yun, Fortin, Pascal D, Hood, Tami, Tyagi, Viraj, Xu, Ming, Zhang, Bailin, Shao, Wenlin
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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Getting Your Hands Dirty Outside the Lab: A Practical Primer for Conducting Wearable Vibrotactile Haptics Research
Blum, Jeffrey R., Fortin, Pascal E., Al Taha, Feras, Alirezaee, Parisa, Demers, Marc, Weill-Duflos, Antoine, Cooperstock, Jeremy R.
Published in IEEE transactions on haptics (01.07.2019)
Published in IEEE transactions on haptics (01.07.2019)
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Enzyme-Dependent Lysine Deprotonation in EZH2 Catalysis
Kipp, D. Randal, Quinn, Christopher M, Fortin, Pascal D
Published in Biochemistry (Easton) (01.10.2013)
Published in Biochemistry (Easton) (01.10.2013)
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Journal Article
Structure–Efficiency Relationship of [1,2,4]Triazol-3-ylamines as Novel Nicotinamide Isosteres that Inhibit Tankyrases
Shultz, Michael D, Majumdar, Dyuti, Chin, Donovan N, Fortin, Pascal D, Feng, Yun, Gould, Ty, Kirby, Christina A, Stams, Travis, Waters, Nigel J, Shao, Wenlin
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Optimization of 3‑Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1
Levell, Julian R., Caferro, Thomas, Chenail, Gregg, Dix, Ina, Dooley, Julia, Firestone, Brant, Fortin, Pascal D., Giraldes, John, Gould, Ty, Growney, Joseph D., Jones, Michael D., Kulathila, Raviraj, Lin, Fallon, Liu, Gang, Mueller, Arne, van der Plas, Simon, Slocum, Kelly, Smith, Troy, Terranova, Remi, Touré, B. Barry, Tyagi, Viraj, Wagner, Trixie, Xie, Xiaoling, Xu, Ming, Yang, Fan S., Zhou, Liping X., Pagliarini, Raymond, Cho, Young Shin
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Characterization of a C—C Bond Hydrolase from Sphingomonas wittichii RW1 with Novel Specificities towards Polychlorinated Biphenyl Metabolites
SEAH, Stephen Y. K, JIYUAN KE, DENIS, Geoffroy, HORSMAN, Geoff P, FORTIN, Pascal D, WHITING, Cheryl J, ELTIS, Lindsay D
Published in Journal of Bacteriology (01.06.2007)
Published in Journal of Bacteriology (01.06.2007)
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Structures of Ternary Complexes of BphK, a Bacterial Glutathione S-Transferase That Reductively Dechlorinates Polychlorinated Biphenyl Metabolites
Tocheva, Elitza I., Fortin, Pascal D., Eltis, Lindsay D., Murphy, Michael E.P.
Published in The Journal of biological chemistry (13.10.2006)
Published in The Journal of biological chemistry (13.10.2006)
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A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines
Walsh, Christopher T, Fortin, Pascal D, Magarvey, Nathan A
Published in Nature (London) (16.08.2007)
Published in Nature (London) (16.08.2007)
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