Dual TTK/PLK1 inhibition has potent anticancer activity in TNBC as monotherapy and in combination
Zanini, Elisa, Forster-Gross, Nicole, Bachmann, Felix, Brüngger, Adrian, McSheehy, Paul, Litherland, Karine, Burger, Karin, Groner, Anna C, Roceri, Mila, Bury, Luc, Stieger, Martin, Willemsen-Seegers, Nicole, de Man, Jos, Vu-Pham, Diep, van Riel, Helma W E, Zaman, Guido J R, Buijsman, Rogier C, Kellenberger, Laurenz, Lane, Heidi A
Published in Frontiers in oncology (09.08.2024)
Published in Frontiers in oncology (09.08.2024)
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Journal Article
신생물성 질환 치료에 사용하기 위한 약제학적 병용물
BACHMANN FELIX, MCSHEEHY PAUL, LANE HEIDI, FORSTER GROSS NICOLE, LITHERLAND KARINE
Year of Publication 08.07.2024
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Year of Publication 08.07.2024
Patent
The FGFR-inhibitor derazantinib (DZB) is active in PDX-models of GI-cancer with specific aberrations in FGFR
McSheehy, Paul, Bachmann, Felix, Forster-Gross, Nicole, El Shemerly, Mahmoud, Roceri, Mila, Kellenberger, Laurenz, Lane, Heidi A
Published in Journal of clinical oncology (01.02.2020)
Published in Journal of clinical oncology (01.02.2020)
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Journal Article
The fibroblast growth factor receptor inhibitor, derazantinib, has strong efficacy in human gastric tumor models and synergizes with paclitaxel in vivo
McSheehy, Paul M J, Forster-Gross, Nicole, El Shemerly, Mahmoud, Bachmann, Felix, Roceri, Mila, Hermann, Norbert, Spickermann, Jochen, Kellenberger, Laurenz, Lane, Heidi A
Published in Anti-cancer drugs (01.04.2023)
Published in Anti-cancer drugs (01.04.2023)
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Derazantinib: an investigational drug for the treatment of cholangiocarcinoma
Braun, Stephan, McSheehy, Paul, Litherland, Karine, McKernan, Phil, Forster-Gross, Nicole, Bachmann, Felix, El-Shemerly, Mahmoud, Dimova-Dobreva, Miryana, Polyakova, Inessa, Häckl, Manuel, Zhou, Ping, Lane, Heidi, Kellenberger, Laurenz, Engelhardt, Marc
Published in Expert opinion on investigational drugs (02.11.2021)
Published in Expert opinion on investigational drugs (02.11.2021)
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Abstract LB-C12: Derazantinib (DZB): A dual FGFR/CSF1R-inhibitor active in PDX-models of urothelial cancer
McSheehy, Paul, Bachmann, Felix, Forster-Gross, Nicole, Lecoultre, Marc, Shemerly, Mahmoud El, Roceri, Mila, Reinelt, Stefan, Kellenberger, Laurenz, Walker, Paul R, Lane, Heidi
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Abstract 2575: Avanbulin, the active moiety of the tumor checkpoint controller lisavanbulin (BAL101553), has anti-lymphoma activity
Spriano, Filippo, Aresu, Luca, Cascione, Luciano, Arribas, Alberto J., Forster-Gross, Nicole, Bachmann, Felix, Lane, Heidi, Bertoni, Francesco
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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The microtubule-targeted agent lisavanbulin (BAL101553) shows anti-tumor activity in lymphoma models
Spriano, Filippo, Aresu, Luca, Cascione, Luciano, Risi, Giorgia, Arribas, Alberto J, Napoli, Sara, Forster-Gross, Nicole, Bachmann, Felix, Engelhardt, Marc, Lane, Heidi, Bertoni, Francesco
Published in American journal of cancer research (01.01.2023)
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Published in American journal of cancer research (01.01.2023)
Journal Article
Abstract 5645: BAL0891: A novel dual TTK/PLK1 mitotic checkpoint inhibitor (MCI) that drives aberrant tumor cell division resulting in potent anti-cancer activity
Lane, Heidi A., Bachmann, Felix, Zanini, Elisa, McSheehy, Paul, Litherland, Karine, Forster-Gross, Nicole, Bury, Luc, Vu-Pham, Diep, de Man, Jos, van Riel, Wilhelmina E., Zaman, Guido JR, Buijsman, Rogier C., Kellenberger, Laurenz
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 5646: BAL0891: A novel, small molecule, dual TTK/PLK1 mitotic checkpoint inhibitor (MCI) that drives aberrant tumor cell division
Zanini, Elisa, Forster-Gross, Nicole, Bachmann, Felix, Willemsen-Seegers, Nicole, de Man, Jos, Zaman, Guido J., Buijsman, Rogier C., Groner, Anna, Roceri, Mila, Burger, Karin, McSheehy, Paul, Kellenberger, Laurenz, Lane, Heidi A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES
LANE, Heidi, LITHERLAND, Karine, FORSTER-GROSS, Nicole, BACHMANN, Felix, MCSHEEHY, Paul
Year of Publication 23.10.2024
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Year of Publication 23.10.2024
Patent
PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES
LANE, Heidi, LITHERLAND, Karine, FORSTER-GROSS, Nicole, BACHMANN, Felix, MCSHEEHY, Paul
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES
MCSHEEHY, PAUL, LITHERLAND, KARINE, BACHMANN, FELIX, LANE, HEIDI, FORSTER-GROSS, NICOLE
Year of Publication 22.06.2023
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Year of Publication 22.06.2023
Patent
PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES
LANE, Heidi, LITHERLAND, Karine, FORSTER-GROSS, Nicole, BACHMANN, Felix, MCSHEEHY, Paul
Year of Publication 22.06.2023
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Year of Publication 22.06.2023
Patent
PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES
LANE Heidi, LITHERLAND Karine, FORSTER-GROSS Nicole, MCSHEEHY Paul, BACHMANN Felix
Year of Publication 04.07.2024
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Year of Publication 04.07.2024
Patent