5-Deazafolate Analogues with a Rotationally Restricted Glutamate or Ornithine Side Chain: Synthesis and Binding Interaction with Folylpolyglutamate Synthetase
Rosowsky, Andre, Forsch, Ronald A, Null, Allison, Moran, Richard G
Published in Journal of medicinal chemistry (09.09.1999)
Published in Journal of medicinal chemistry (09.09.1999)
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Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity
Westerhof, G R, Schornagel, J H, Kathmann, I, Jackman, A L, Rosowsky, A, Forsch, R A, Hynes, J B, Boyle, F T, Peters, G J, Pinedo, H M
Published in Molecular pharmacology (01.09.1995)
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Published in Molecular pharmacology (01.09.1995)
Journal Article
Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductases by 2,4-Diamino-5-[2-methoxy-5-(ω-carboxyalkyloxy)benzyl]pyrimidines: Marked Improvement in Potency Relative to Trimethoprim and Species Selectivity Relative to Piritrexim
Rosowsky, Andre, Forsch, Ronald A, Queener, Sherry F
Published in Journal of medicinal chemistry (03.01.2002)
Published in Journal of medicinal chemistry (03.01.2002)
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Journal Article
Regiospecific gamma-conjugation of methotrexate to poly(L-lysine). Chemical and biological studies
ROSOWSKY, A, FORSCH, R. A, GALIVAN, J, SUSTEN, S. S, FREISHEIM, J. H
Published in Molecular pharmacology (01.01.1985)
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Published in Molecular pharmacology (01.01.1985)
Journal Article
Analogues of the Potent Nonpolyglutamatable Antifolate N α-(4-Amino-4-deoxypteroyl)-N δ-hemiphthaloyl-l-ornithine (PT523) with Modifications in the Side Chain, p-Aminobenzoyl Moiety, or 9,10-Bridge: Synthesis and in Vitro Antitumor Activity
Rosowsky, Andre, Wright, Joel E, Vaidya, Chitra M, Forsch, Ronald A, Bader, Henry
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
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Synthesis and Potent Antifolate Activity and Cytotoxicity of B-Ring Deaza Analogues of the Nonpolyglutamatable Dihydrofolate Reductase Inhibitor N α-(4-Amino-4-deoxypteroyl)-N δ-hemiphthaloyl-l-ornithine (PT523)
Rosowsky, Andre, Wright, Joel E, Vaidya, Chitra M, Bader, Henry, Forsch, Ronald A, Mota, Clara E, Pardo, Jorge, Chen, Cindy S, Chen, Ying-Nan
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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A mechanism for the addition of multiple moles of glutamate by folylpolyglutamate synthetase
Moran, Richard G, Colman, Paul D, Forsch, Ronald A, Rosowsky, Andre
Published in Journal of medicinal chemistry (01.10.1984)
Published in Journal of medicinal chemistry (01.10.1984)
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Journal Article
Synthesis of γ-[15N]-L-glutamyl derivatives of 5,10-dideazatetrahydrofolate
Forsch, Ronald A., Rosowsky, Andre
Published in Journal of labelled compounds & radiopharmaceuticals (01.11.1999)
Published in Journal of labelled compounds & radiopharmaceuticals (01.11.1999)
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Journal Article
The 2-desamino and 2-desamino-2-methyl analogs of aminopterin do not inhibit dihydrofolate reductase but are potently toxic to tumor cells in culture
Rosowsky, Andre, Forsch, Ronald A, Freisheim, James H, Moran, Richard G
Published in Journal of medicinal chemistry (01.03.1989)
Published in Journal of medicinal chemistry (01.03.1989)
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Journal Article
Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition
Rosowsky, A, Forsch, R A, Moran, R G, Kohler, W, Freisheim, J H
Published in Journal of medicinal chemistry (01.07.1988)
Published in Journal of medicinal chemistry (01.07.1988)
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Journal Article
Methotrexate Analogues. 25. Chemical and Biological Studies on the γ-tert-Butyl Esters of Methotrexate and Aminopterin
Rosowsky, Andre, Freisheim, James H, Bader, Henry, Forsch, Ronald A, Susten, Sandra S, Cucchi, Carol A, Frie, Emil
Published in Journal of medicinal chemistry (01.05.1985)
Published in Journal of medicinal chemistry (01.05.1985)
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Journal Article
Methotrexate analogs. 19. Replacement of the glutamate side-chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity
Rosowsky, Andre, Forsch, Ronald A, Freisheim, James H, Moran, Richard G, Wick, Michael
Published in Journal of medicinal chemistry (01.05.1984)
Published in Journal of medicinal chemistry (01.05.1984)
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