Discovery, Synthesis, and Optimization of Antimalarial 4(1H)‑Quinolone-3-Diarylethers
Nilsen, Aaron, Miley, Galen P, Forquer, Isaac P, Mather, Michael W, Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M, Stickles, Allison M, Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L, Hinrichs, David J, Winter, Rolf W, Charman, Susan A, Zakharov, Lev N, Bathurst, Ian, Burrows, Jeremy N, Vaidya, Akhil B, Riscoe, Michael K
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Published in Journal of medicinal chemistry (08.05.2014)
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Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone
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Published in The Journal of experimental medicine (27.06.2016)
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Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy
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Published in The American journal of tropical medicine and hygiene (03.06.2015)
Published in The American journal of tropical medicine and hygiene (03.06.2015)
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Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria
Stickles, Allison M, Smilkstein, Martin J, Morrisey, Joanne M, Li, Yuexin, Forquer, Isaac P, Kelly, Jane X, Pou, Sovitj, Winter, Rolf W, Nilsen, Aaron, Vaidya, Akhil B, Riscoe, Michael K
Published in Antimicrobial agents and chemotherapy (01.08.2016)
Published in Antimicrobial agents and chemotherapy (01.08.2016)
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Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum
Stickles, Allison M, de Almeida, Mariana Justino, Morrisey, Joanne M, Sheridan, Kayla A, Forquer, Isaac P, Nilsen, Aaron, Winter, Rolf W, Burrows, Jeremy N, Fidock, David A, Vaidya, Akhil B, Riscoe, Michael K
Published in Antimicrobial agents and chemotherapy (01.04.2015)
Published in Antimicrobial agents and chemotherapy (01.04.2015)
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Quinolone-3-diarylethers: a new class of antimalarial drug
Nilsen, Aaron, LaCrue, Alexis N, White, Karen L, Forquer, Isaac P, Cross, Richard M, Marfurt, Jutta, Mather, Michael W, Delves, Michael J, Shackleford, David M, Saenz, Fabian E, Morrisey, Joanne M, Steuten, Jessica, Mutka, Tina, Li, Yuexin, Wirjanata, Grennady, Ryan, Eileen, Duffy, Sandra, Kelly, Jane Xu, Sebayang, Boni F, Zeeman, Anne-Marie, Noviyanti, Rintis, Sinden, Robert E, Kocken, Clemens H M, Price, Ric N, Avery, Vicky M, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Ferrer, Santiago, Herreros, Esperanza, Sanz, Laura M, Gamo, Francisco-Javier, Bathurst, Ian, Burrows, Jeremy N, Siegl, Peter, Guy, R Kiplin, Winter, Rolf W, Vaidya, Akhil B, Charman, Susan A, Kyle, Dennis E, Manetsch, Roman, Riscoe, Michael K
Published in Science translational medicine (20.03.2013)
Published in Science translational medicine (20.03.2013)
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ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria
Miley, Galen P, Pou, Sovitj, Winter, Rolf, Nilsen, Aaron, Li, Yuexin, Kelly, Jane X, Stickles, Allison M, Mather, Michael W, Forquer, Isaac P, Pershing, April M, White, Karen, Shackleford, David, Saunders, Jessica, Chen, Gong, Ting, Li-Min, Kim, Kami, Zakharov, Lev N, Donini, Cristina, Burrows, Jeremy N, Vaidya, Akhil B, Charman, Susan A, Riscoe, Michael K
Published in Antimicrobial agents and chemotherapy (01.09.2015)
Published in Antimicrobial agents and chemotherapy (01.09.2015)
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Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria
Frueh, Lisa, Li, Yuexin, Mather, Michael W, Li, Qigui, Pou, Sovitj, Nilsen, Aaron, Winter, Rolf W, Forquer, Isaac P, Pershing, April M, Xie, Lisa H, Smilkstein, Martin J, Caridha, Diana, Koop, Dennis R, Campbell, Robert F, Sciotti, Richard J, Kreishman-Deitrick, Mara, Kelly, Jane X, Vesely, Brian, Vaidya, Akhil B, Riscoe, Michael K
Published in ACS infectious diseases (13.10.2017)
Published in ACS infectious diseases (13.10.2017)
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Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc 1 Inhibition Strategy for Malaria
Stickles, Allison M., Smilkstein, Martin J., Morrisey, Joanne M., Li, Yuexin, Forquer, Isaac P., Kelly, Jane X., Pou, Sovitj, Winter, Rolf W., Nilsen, Aaron, Vaidya, Akhil B., Riscoe, Michael K.
Published in Antimicrobial agents and chemotherapy (01.08.2016)
Published in Antimicrobial agents and chemotherapy (01.08.2016)
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Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochrome bc 1 Complex of Plasmodium falciparum
Stickles, Allison M., de Almeida, Mariana Justino, Morrisey, Joanne M., Sheridan, Kayla A., Forquer, Isaac P., Nilsen, Aaron, Winter, Rolf W., Burrows, Jeremy N., Fidock, David A., Vaidya, Akhil B., Riscoe, Michael K.
Published in Antimicrobial agents and chemotherapy (01.04.2015)
Published in Antimicrobial agents and chemotherapy (01.04.2015)
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