Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors
Bouquet, J., Auberger, N., Ashmus, R., King, D., Bordes, A., Fontelle, N., Nakagawa, S., Madden, Z., Proceviat, C., Kato, A., Desire, J., Vocadlo, D. J., Bleriot, Y.
Published in Organic & biomolecular chemistry (19.01.2022)
Published in Organic & biomolecular chemistry (19.01.2022)
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N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors
Desire, J., Mondon, M., Fontelle, N., Nakagawa, S., Hirokami, Y., Adachi, I., Iwaki, R., Fleet, G. W. J., Alonzi, D. S., Twigg, G., Butters, T. D., Bertrand, J., Cendret, V., Becq, F., Norez, C., Marrot, J., Kato, A., Bleriot, Y.
Published in Organic & biomolecular chemistry (28.11.2014)
Published in Organic & biomolecular chemistry (28.11.2014)
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Journal Article
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and -alkylation leads to low micromolar HexAB and NagZ inhibitors
Bouquet, J, Auberger, N, Ashmus, R, King, D, Bordes, A, Fontelle, N, Nakagawa, S, Madden, Z, Proceviat, C, Kato, A, Désiré, J, Vocadlo, D. J, Blériot, Y
Published in Organic & biomolecular chemistry (19.01.2022)
Published in Organic & biomolecular chemistry (19.01.2022)
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Journal Article
N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctorsElectronic supplementary information (ESI) available: Copies of the 1H and 13C spectra. CCDC 970784. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4ob00325j
Désiré, J, Mondon, M, Fontelle, N, Nakagawa, S, Hirokami, Y, Adachi, I, Iwaki, R, Fleet, G. W. J, Alonzi, D. S, Twigg, G, Butters, T. D, Bertrand, J, Cendret, V, Becq, F, Norez, C, Marrot, J, Kato, A, Blériot, Y
Year of Publication 21.10.2014
Year of Publication 21.10.2014
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