Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
Soldner, Frank, Laganière, Josée, Cheng, Albert W., Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I., Myers, Richard H., Lindquist, Susan, Zhang, Lei, Guschin, Dmitry, Fong, Lauren K., Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D., Rebar, Edward J., Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf
Published in Cell (22.07.2011)
Published in Cell (22.07.2011)
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Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein
Young, Jessica E., Fong, Lauren K., Frankowski, Harald, Petsko, Gregory A., Small, Scott A., Goldstein, Lawrence S.B.
Published in Stem cell reports (13.03.2018)
Published in Stem cell reports (13.03.2018)
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Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells
Almenar-Queralt, Angels, Merkurjev, Daria, Kim, Hong Sook, Navarro, Michael, Ma, Qi, Chaves, Rodrigo S, Allegue, Catarina, Driscoll, Shawn P, Chen, Andrew G, Kohlnhofer, Bridget, Fong, Lauren K, Woodruff, Grace, Mackintosh, Carlos, Bohaciakova, Dasa, Hruska-Plochan, Marian, Tadokoro, Takahiro, Young, Jessica E, El Hajj, Nady, Dittrich, Marcus, Marsala, Martin, Goldstein, Lawrence S B, Garcia-Bassets, Ivan
Published in Nature genetics (01.12.2019)
Published in Nature genetics (01.12.2019)
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An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease
Laganiere, Josee, Kells, Adrian P, Lai, Jeffrey T, Guschin, Dmitry, Paschon, David E, Meng, Xiangdong, Fong, Lauren K, Yu, Qi, Rebar, Edward J, Gregory, Philip D, Bankiewicz, Krystof S, Forsayeth, John, Zhang, H Steve
Published in The Journal of neuroscience (08.12.2010)
Published in The Journal of neuroscience (08.12.2010)
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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
van der Kant, Rik, Langness, Vanessa F., Herrera, Cheryl M., Williams, Daniel A., Fong, Lauren K., Leestemaker, Yves, Steenvoorden, Evelyne, Rynearson, Kevin D., Brouwers, Jos F., Helms, J. Bernd, Ovaa, Huib, Giera, Martin, Wagner, Steven L., Bang, Anne G., Goldstein, Lawrence S.B.
Published in Cell stem cell (07.03.2019)
Published in Cell stem cell (07.03.2019)
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A chemical approach facilitates CRISPRa-only human iPSC generation and minimizes the number of targeted loci required
Abujarour, Ramzey, Dinella, Jason, Pribadi, Mochtar, Fong, Lauren K, Denholtz, Matthew, Gutierrez, Alma, Haynes, Matt, Mahmood, Enaaya, Lee, Tom T, Ding, Sheng, Valamehr, Bahram
Published in Future science OA (01.01.2024)
Published in Future science OA (01.01.2024)
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Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes
Fong, Lauren K., Yang, Max M., dos Santos Chaves, Rodrigo, Reyna, Sol M., Langness, Vanessa F., Woodruff, Grace, Roberts, Elizabeth A., Young, Jessica E., Goldstein, Lawrence S.B.
Published in The Journal of biological chemistry (20.07.2018)
Published in The Journal of biological chemistry (20.07.2018)
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Journal Article
Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
Soldner, Frank, Laganière, Josée, Cheng, Albert W., Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I., Myers, Richard H., Lindquist, Susan, Zhang, Lei, Guschin, Dmitry, Fong, Lauren K., Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D., Rebar, Edward J., Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf
Published in Cell (19.08.2011)
Published in Cell (19.08.2011)
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