The Expanding Therapeutic Utility of Botulinum Neurotoxins
Fonfria, Elena, Maignel, Jacquie, Lezmi, Stephane, Martin, Vincent, Splevins, Andrew, Shubber, Saif, Kalinichev, Mikhail, Foster, Keith, Picaut, Philippe, Krupp, Johannes
Published in Toxins (18.05.2018)
Published in Toxins (18.05.2018)
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Journal Article
Replacement of the Mouse LD50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations
Fonfria, Elena, Marks, Elizabeth, Foulkes, Lisa-Marie, Schofield, Rebecca, Higazi, Daniel, Coward, Sam, Kippen, Alistair
Published in Toxins (29.04.2023)
Published in Toxins (29.04.2023)
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Journal Article
hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins
Lamotte, Juliette Duchesne De, Roqueviere, Sylvain, Gautier, Hélène, Raban, Elsa, Bouré, Céline, Fonfria, Elena, Krupp, Johannes, Nicoleau, Camille
Published in Frontiers in pharmacology (14.01.2021)
Published in Frontiers in pharmacology (14.01.2021)
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Journal Article
Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity
Fonfria, Elena, Elliott, Mark, Beard, Matthew, Chaddock, John A, Krupp, Johannes
Published in Toxins (04.07.2018)
Published in Toxins (04.07.2018)
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Journal Article
A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo
Donald, Sarah, Elliott, Mark, Gray, Bryony, Hornby, Fraser, Lewandowska, Agnieszka, Marlin, Sandra, Favre‐Guilmard, Christine, Périer, Cindy, Cornet, Sylvie, Kalinichev, Mikhail, Krupp, Johannes, Fonfria, Elena
Published in Pharmacology research & perspectives (01.12.2018)
Published in Pharmacology research & perspectives (01.12.2018)
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Journal Article
Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists
GLEAVE, Robert J, WALTER, Daryl S, BESWICK, Paul J, FONFRIA, Elena, MICHEL, Anton D, ROMAN, Shilina A, TANG, Sac-Pham
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia
Fonfria, Elena, Mattei, Cesar, Hill, Kerstin, Brown, Jon T, Randall, Andrew, Benham, Christopher D, Skaper, Stephen D, Campbell, Colin A, Crook, Barry, Murdock, Paul R, Wilson, Jennifer M, Maurio, Frank P, Owen, Davina E, Tilling, Paula L, McNulty, Shaun
Published in Journal of receptors and signal transduction (2006)
Published in Journal of receptors and signal transduction (2006)
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Journal Article
High-throughput techniques enable structure-guided drug discovery against the inflammatory target NLRP3
Thompson, Andrew, Zarganis-Tzitzikas, Tryfon, Lowe, Martin, Fonfria, Elena, Murphy, Emma, von Delft, Frank, Brennan, Paul
Published in Acta crystallographica. Section A, Foundations and advances (22.08.2023)
Published in Acta crystallographica. Section A, Foundations and advances (22.08.2023)
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Journal Article
Development of a cell-based assay to replace LD50 for botulinum toxin A1
Fonfria, Elena, Foulkes, Lisa-Marie, Coward, Sam, Kippen, Alistair
Published in Toxicon (Oxford) (01.12.2018)
Published in Toxicon (Oxford) (01.12.2018)
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Journal Article
Replacement of the Mouse LD[sub.50] Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations
Fonfria, Elena, Marks, Elizabeth, Foulkes, Lisa-Marie, Schofield, Rebecca, Higazi, Daniel, Coward, Sam, Kippen, Alistair
Published in Toxins (01.04.2023)
Published in Toxins (01.04.2023)
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Journal Article
Use of high-content imaging in botulinum toxin research
Fonfria, Elena, Donald, Sarah, Cadd, Verity A., Krupp, Johannes
Published in Toxicon (Oxford) (25.12.2016)
Published in Toxicon (Oxford) (25.12.2016)
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Journal Article
Translational value of hiPSC-derived models for botulinum neurotoxin research
Nicoleau, Camille, Donald, Sarah, Pons, Laurent, De Lamotte, Juliette Duchesne, Raban, Elsa, Fonfria, Elena, Krupp, Johannes
Published in Toxicon (Oxford) (01.12.2018)
Published in Toxicon (Oxford) (01.12.2018)
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Journal Article
Replacement of the Mouse LD 50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations
Fonfria, Elena, Marks, Elizabeth, Foulkes, Lisa-Marie, Schofield, Rebecca, Higazi, Daniel, Coward, Sam, Kippen, Alistair
Published in Toxins (29.04.2023)
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Published in Toxins (29.04.2023)
Journal Article
105. Effect of botulinum neurotoxin type A subtypes on guinea pig isolated ileum smooth muscle
Hornby, Fraser, Hedley, Diana, Fonfria, Elena, Krupp, Johannes
Published in Toxicon (Oxford) (01.01.2015)
Published in Toxicon (Oxford) (01.01.2015)
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Journal Article
Potency comparison in in vitro, ex vivo, and in vivo assays of commercially available botulinum neurotoxin serotypes A1, B1, and F1
Donald, Sarah, Elliott, Mark, Gray, Bryony, Hornby, Fraser, Lewandowska, Agnieszka, Marlin, Sandra, Favre-Guilmard, Christine, Perier, Cindy, Cornet, Sylvie, Kalinichev, Mikhail, Krupp, Johannes, Fonfria, Elena
Published in Toxicon (Oxford) (01.12.2018)
Published in Toxicon (Oxford) (01.12.2018)
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Journal Article
Rational modification of botulinum neurotoxin by directed scanning mutagenesis
Liu, Sai Man, Hackett, Gavin, Fonfria, Elena, Palan, Shilpa, Cornet, Sylvie, Lewandowska, Agnieszka, Donald, Sarah, Burgin, Dave, Sopp, Joshua, Hornby, Fraser, Marlin, Sandra, Perier, Cindy, Anderson, Dina
Published in Toxicon (Oxford) (25.12.2016)
Published in Toxicon (Oxford) (25.12.2016)
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Journal Article
11. Functional characterization of BoNT/A subtypes
Auguet, Michel, Johnstone, Stephen, Palan, Shilpa, Wilson, Annie, Hedley, Diana, Fonfria, Elena, Hackett, Gavin, Liu, Sai, Donald, Sarah, Hornby, Fraser, Anderson, Dina, Beard, Matthew
Published in Toxicon (Oxford) (01.01.2015)
Published in Toxicon (Oxford) (01.01.2015)
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Journal Article