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4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H3 Receptor Antagonists

4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H3 Receptor Antagonists

by Procopiou, Panayiotis A, Ancliff, Rachael A, Bamford, Mark J, Browning, Christopher, Connor, Helen, Davies, Susannah, Fogden, Yvonne C, Hodgson, Simon T, Holmes, Duncan S, Looker, Brian E, Morriss, Karen M. L, Parr, Christopher A, Pickup, Elizabeth A, Sehmi, Sanjeet S, White, Gemma V, Watts, Clarissa J, Wilson, David M, Woodrow, Michael D
Published in Journal of medicinal chemistry (27.12.2007)

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Journal Article

4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H-3 receptor antagonists

4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H-3 receptor antagonists

by Procopiou, Panayiotis A., Ancliff, Rachael A., Bamford, Mark J., Browning, Christopher, Connor, Helen, Davies, Susannah, Fogden, Yvonne C., Hodgson, Simon T., Holmes, Duncan S., Looker, Brian E., Morriss, Karen M. L., Parr, Christopher A., Pickup, Elizabeth A., Sehmi, Sanjeet S., White, Gemma V., Watts, Clarissa J., Wilson, David M., Woodrow, Michael D.
Published in Journal of medicinal chemistry (27.12.2007)

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Journal Article

Substituted piperazines, (1,4) diazepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists

Substituted piperazines, (1,4) diazepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists

by LINDON, MATTHEW J, HODGSON, SIMON TEANBY, WILSON, DAVID MATTHEW, ANCLIFF, RACHAEL, FOGDEN, YVONNE C, HEIGHTMAN, THOMAS DANIEL, HOBBS, HEATHER, HANCOCK, ASHLEY PAUL, ELDRED, COLIN DAVID
Year of Publication 28.03.2008

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Patent

Substituted piperazines (1,4) diaszepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine h1 and/or h3 antagonists or histamine h3 reverse antagonists

Substituted piperazines (1,4) diaszepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine h1 and/or h3 antagonists or histamine h3 reverse antagonists

by ANCLIFF RANCHAEL,ELDRED COLIN D.,FOGDEN YVONNE C.,HANCOCK ASHLEY P.,HEIGHTMAN THOMAS D.,HOBBS HEATHER,HODGSON SIMON T.,LINDON MATTHEW J.,WILSON DAVIDM
Year of Publication 14.11.2007

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Patent

Substituted piperazines, (1,4) diaszepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine H1 and/or H3 antagonists of histamine H3 reverse antagonists

Substituted piperazines, (1,4) diaszepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine H1 and/or H3 antagonists of histamine H3 reverse antagonists

by LINDON, MATTHEW J, HODGSON, SIMON TEANBY, WILSON, DAVID MATTHEW, ANCLIFF, RACHAEL, FOGDEN, YVONNE C, HEIGHTMAN, THOMAS DANIEL, HOBBS, HEATHER, HANCOCK, ASHLEY PAUL, ELDRED, COLIN DAVID
Year of Publication 25.04.2007

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Patent

SUBSTITUTED PIPERAZINE, (1,4)DIAZEPINE AND 2,5-DIAZACYCLO[2.2.1]HEPTANE AS HISTAMINE H1 AND/OR H3 ANTAGONIST OR H3 REVERSE ANTAGONIST

SUBSTITUTED PIPERAZINE, (1,4)DIAZEPINE AND 2,5-DIAZACYCLO[2.2.1]HEPTANE AS HISTAMINE H1 AND/OR H3 ANTAGONIST OR H3 REVERSE ANTAGONIST

by LINDON MATTHEW J, HEIGHTMAN THOMAS DANIEL, FOGDEN YVONNE C, WILSON DAVID MATTHEW, HODGSON SIMON TEANBY, ELDRED COLIN DAVID, HOBBS HEATHER, ANCLIFF RACHEL, HANCOCK ASHLEY PAUL
Year of Publication 25.01.2007

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Patent

Substituted piperazines, (1,4) diazepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists

Substituted piperazines, (1,4) diazepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists

by LINDON, MATTHEW J, HODGSON, SIMON TEANBY, WILSON, DAVID MATTHEW, ANCLIFF, RACHAEL, FOGDEN, YVONNE C, HEIGHTMAN, THOMAS DANIEL, HOBBS, HEATHER, HANCOCK, ASHLEY PAUL, ELDRED, COLIN DAVID
Year of Publication 30.11.2006

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Patent

Substituted piperazines (1,4) diaszepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists

Substituted piperazines (1,4) diaszepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists

by ELDRED, COLIN, D, LINDON, MATTHEW, J, FOGDEN, YVONNE, C, WILSON, DAVID, M, RACHAEL ANCLIFF, HEATHER HOBBS, HODGSON, SIMON, T, HANCOCK, ASHLEY, P, HEIGHTMAN, THOMAS, D
Year of Publication 26.07.2006

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Patent

Compounds

Compounds

by HEIGHTMAN THOMAS D, HODGSON SIMON T, LINDON MATTHEW J, FOGDEN YVONNE C, ELDRED COLIN D, HANCOCK ASHLEY P, HOBBS HEATHER, WILSON DAVID M, ANCLIFF RANCHAEL A
Year of Publication 26.01.2006

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Patent

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

by LINDON MATTHEW J, HEIGHTMAN THOMAS DANIEL, FOGDEN YVONNE C, WILSON DAVID MATTHEW, HODGSON SIMON TEANBY, ANCLIFF RACHAEL, ELDRED COLIN DAVID, HOBBS HEATHER, HANCOCK ASHLEY PAUL
Year of Publication 27.12.2005

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Patent

SUBSTITUTED PIPERAZINES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

SUBSTITUTED PIPERAZINES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

by LINDON, MATTHEW J, HODGSON, SIMON TEANBY, WILSON, DAVID MATTHEW, ANCLIFF, RACHAEL, FOGDEN, YVONNE C, HEIGHTMAN, THOMAS DANIEL, HOBBS, HEATHER, HANCOCK, ASHLEY PAUL, ELDRED, COLIN DAVID
Year of Publication 31.08.2005

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Patent

SUBSTITUTED PIPERAZINES, (1,4)DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

SUBSTITUTED PIPERAZINES, (1,4)DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

by HODGSON, SIMON, TEANBY, ELDRED, COLIN, DAVID, LINDON, MATTHEW, J, FOGDEN, YVONNE, C, HANCOCK, ASHLEY, PAUL, WILSON, DAVID, MATTHEW, HEIGHTMAN, THOMAS, DANIEL, ANCLIFF, RACHAEL, HOBBS, HEATHER
Year of Publication 25.05.2005

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Patent

Setin píperasín, (1,4) díassepín og 2,5-díasabísýkló (2.2.1) heptön sem histamín H1 og/eða H3 mótlyf eða histamín H3 gagnmótlyf

Setin píperasín, (1,4) díassepín og 2,5-díasabísýkló (2.2.1) heptön sem histamín H1 og/eða H3 mótlyf eða histamín H3 gagnmótlyf

by RACHAEL ANCLIFF, HEATHER HOBBS, DAVID MATTHEW WILSON, MATTHEW J. LINDON, THOMAS DANIEL HEIGHTMAN, ASHLEY PAUL HANCOCK, SIMON TEANBY HODGSON, COLIN DAVID ELDRED, YVONNE C. FOGDEN
Year of Publication 31.03.2005

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Patent

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

by COLIN, DAVID ELDRED, DAVID, MATTHEW WILSON, RACHAEL ANCLIFF, SIMON, TEANBY HODGSON, HEATHER HOBBS, THOMAS, DANIEL HEIGHTMAN, MATTHEW, J LINDON, YVONNE, C FOGDEN, ASHLEY, PAUL HANCOCK
Year of Publication 04.05.2004

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Patent

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

by LINDON, MATTHEW J, HODGSON, SIMON TEANBY, WILSON, DAVID MATTHEW, FOGDEN, YVONNE C, ANCLIFF, RACHAEL, HEIGHTMAN, THOMAS DANIEL, HOBBS, HEATHER, HANCOCK, ASHLEY PAUL, ELDRED, COLIN DAVID
Year of Publication 29.04.2004

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Patent

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

by HODGSON, SIMON, TEANBY, ELDRED, COLIN, DAVID, LINDON, MATTHEW, J, FOGDEN, YVONNE, C, HANCOCK, ASHLEY, PAUL, WILSON, DAVID, MATTHEW, HEIGHTMAN, THOMAS, DANIEL, ANCLIFF, RACHAEL, HOBBS, HEATHER
Year of Publication 29.04.2004

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Patent

Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, e, método de tratamento de doenças neurológicas ou de doenças inflamatórias do trato respiratório superior

Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, e, método de tratamento de doenças neurológicas ou de doenças inflamatórias do trato respiratório superior

by RACHAEL ANCLIFF, HEATHER HOBBS, DAVID MATTHEW WILSON, MATTHEW J. LINDON, THOMAS DANIEL HEIGHTMAN, ASHLEY PAUL HANCOCK, SIMON TEANBY HODGSON, COLIN DAVID ELDRED, YVONNE C. FOGDEN
Year of Publication 30.08.2005

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Patent

PIPERAZINES, (1,4) DIAZEPINES, ET 2,5-DIAZABICYCLO (2.2.1) HEPTANES SUBSTITUES EN TANT QU'ANTAGONISTES DE L'HISTAMINE H1 ET/OU H3 OU ANTAGONISTES INVERSES DE L'HISTAMINE H3

PIPERAZINES, (1,4) DIAZEPINES, ET 2,5-DIAZABICYCLO (2.2.1) HEPTANES SUBSTITUES EN TANT QU'ANTAGONISTES DE L'HISTAMINE H1 ET/OU H3 OU ANTAGONISTES INVERSES DE L'HISTAMINE H3

by HODGSON, SIMON, TEANBY, ELDRED, COLIN, DAVID, LINDON, MATTHEW, J, FOGDEN, YVONNE, C, HANCOCK, ASHLEY, PAUL, WILSON, DAVID, MATTHEW, HEIGHTMAN, THOMAS, DANIEL, RACHAEL, ANCLIFF, HOBBS, HEATHER
Year of Publication 01.08.2005

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Patent

Substituerte piperaziner, (1,4) diaszepiner og 2,5-diazabicyklo(2.2.1) heptaner som histamin H1 og/eller H3 antagonister eller histamin H3 revers antagonister

Substituerte piperaziner, (1,4) diaszepiner og 2,5-diazabicyklo(2.2.1) heptaner som histamin H1 og/eller H3 antagonister eller histamin H3 revers antagonister

by ANCLIFF RACHAEL ANNE, LINDON MATTHEW J, HEIGHTMAN THOMAS DANIEL, WILSON DAVID MATTHEW, FOGDEN YVONNE C, ELDRED COLIN DAVID, HOBBS HEATHER, HODGSON SIMON TENNBY, HANCOCK ASHLEY PAUL
Year of Publication 07.07.2005

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Patent