Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis
Renault, Thibaud T., Floros, Konstantinos V., Elkholi, Rana, Corrigan, Kelly-Ann, Kushnareva, Yulia, Wieder, Shira Y., Lindtner, Claudia, Serasinghe, Madhavika N., Asciolla, James J., Buettner, Christoph, Newmeyer, Donald D., Chipuk, Jerry E.
Published in Molecular cell (08.01.2015)
Published in Molecular cell (08.01.2015)
Get full text
Journal Article
MYCN -Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis
Floros, Konstantinos V, Cai, JinYang, Jacob, Sheeba, Kurupi, Richard, Fairchild, Carter K, Shende, Mayuri, Coon, Colin M, Powell, Krista M, Belvin, Benjamin R, Hu, Bin, Puchalapalli, Madhavi, Ramamoorthy, Sivapriya, Swift, Kimberly, Lewis, Janina P, Dozmorov, Mikhail G, Glod, John, Koblinski, Jennifer E, Boikos, Sosipatros A, Faber, Anthony C
Published in Cancer research (Chicago, Ill.) (01.04.2021)
Published in Cancer research (Chicago, Ill.) (01.04.2021)
Get full text
Journal Article
Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer
Kitai, Hidenori, Ebi, Hiromichi, Tomida, Shuta, Floros, Konstantinos V, Kotani, Hiroshi, Adachi, Yuta, Oizumi, Satoshi, Nishimura, Masaharu, Faber, Anthony C, Yano, Seiji
Published in Cancer discovery (01.07.2016)
Published in Cancer discovery (01.07.2016)
Get full text
Journal Article
Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma
Lochmann, Timothy L, Powell, Krista M, Ham, Jungoh, Floros, Konstantinos V, Heisey, Daniel A R, Kurupi, Richard I J, Calbert, Marissa L, Ghotra, Maninderjit S, Greninger, Patricia, Dozmorov, Mikhail, Gowda, Madhu, Souers, Andrew J, Reynolds, C Patrick, Benes, Cyril H, Faber, Anthony C
Published in Science translational medicine (16.05.2018)
Published in Science translational medicine (16.05.2018)
Get more information
Journal Article
Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Song, Kyung-A, Niederst, Matthew J, Lochmann, Timothy L, Hata, Aaron N, Kitai, Hidenori, Ham, Jungoh, Floros, Konstantinos V, Hicks, Mark A, Hu, Haichuan, Mulvey, Hillary E, Drier, Yotam, Heisey, Daniel A R, Hughes, Mark T, Patel, Neha U, Lockerman, Elizabeth L, Garcia, Angel, Gillepsie, Shawn, Archibald, Hannah L, Gomez-Caraballo, Maria, Nulton, Tara J, Windle, Brad E, Piotrowska, Zofia, Sahingur, Sinem E, Taylor, Shirley M, Dozmorov, Mikhail, Sequist, Lecia V, Bernstein, Bradley, Ebi, Hiromichi, Engelman, Jeffrey A, Faber, Anthony C
Published in Clinical cancer research (01.01.2018)
Published in Clinical cancer research (01.01.2018)
Get full text
Journal Article
Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors
Floros, Konstantinos V., Jacob, Sheeba, Kurupi, Richard, Fairchild, Carter K., Hu, Bin, Puchalapalli, Madhavi, E. Koblinski, Jennifer, Dozmorov, Mikhail G., Boikos, Sosipatros A., Scaltriti, Maurizio, Faber, Anthony C.
Published in Cell death & disease (15.02.2021)
Published in Cell death & disease (15.02.2021)
Get full text
Journal Article
MYCN upregulates the transsulfuration pathway to suppress the ferroptotic vulnerability in MYCN -amplified neuroblastoma
Floros, Konstantinos V, Chawla, Ayesha T, Johnson-Berro, Mia O, Khatri, Rishabh, Stamatouli, Angeliki M, Boikos, Sosipatros A, Dozmorov, Mikhail G, Cowart, L Ashley, Faber, Anthony C
Published in Cell Stress (01.02.2022)
Published in Cell Stress (01.02.2022)
Get full text
Journal Article
Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA
Fairchild, Carter K., Floros, Konstantinos V., Jacob, Sheeba, Coon, Colin M., Puchalapalli, Madhavi, Hu, Bin, Harada, Hisashi, Dozmorov, Mikhail G., Koblinski, Jennifer E., Smith, Steven C., Domson, Gregory, Leverson, Joel D., Souers, Andrew J., Takebe, Naoko, Ebi, Hiromichi, Faber, Anthony C., Boikos, Sosipatros A.
Published in Cancers (12.05.2021)
Published in Cancers (12.05.2021)
Get full text
Journal Article
Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression
Lochmann, Timothy L, Floros, Konstantinos V, Naseri, Mitra, Powell, Krista M, Cook, Wade, March, Ryan J, Stein, Giovanna T, Greninger, Patricia, Maves, Yuki Kato, Saunders, Laura R, Dylla, Scott J, Costa, Carlotta, Boikos, Sosipatros A, Leverson, Joel D, Souers, Andrew J, Krystal, Geoffrey W, Harada, Hisashi, Benes, Cyril H, Faber, Anthony C
Published in Clinical cancer research (15.01.2018)
Published in Clinical cancer research (15.01.2018)
Get full text
Journal Article
BAK/BAX activation and cytochrome c release assays using isolated mitochondria
Renault, Thibaud T., Floros, Konstantinos V., Chipuk, Jerry E.
Published in Methods (San Diego, Calif.) (01.06.2013)
Published in Methods (San Diego, Calif.) (01.06.2013)
Get full text
Journal Article
Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN-amplified neuroblastoma
Dalton, Krista M., Lochmann, Timothy L., Floros, Konstantinos V., Calbert, Marissa L., Kurupi, Richard, Stein, Giovanna T., McClanaghan, Joseph, Murchie, Ellen, Egan, Regina K., Greninger, Patricia, Dozmorov, Mikhail, Ramamoorthy, Sivapriya, Puchalapalli, Madhavi, Hu, Bin, Shock, Lisa, Koblinski, Jennifer, Glod, John, Boikos, Sosipatros A., Benes, Cyril H., Faber, Anthony C.
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.2021)
Get full text
Journal Article
Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination
Ham, Jungoh, Costa, Carlotta, Sano, Renata, Lochmann, Timothy L., Sennott, Erin M., Patel, Neha U., Dastur, Anahita, Gomez-Caraballo, Maria, Krytska, Kateryna, Hata, Aaron N., Floros, Konstantinos V., Hughes, Mark T., Jakubik, Charles T., Heisey, Daniel A.R., Ferrell, Justin T., Bristol, Molly L., March, Ryan J., Yates, Craig, Hicks, Mark A., Nakajima, Wataru, Gowda, Madhu, Windle, Brad E., Dozmorov, Mikhail G., Garnett, Mathew J., McDermott, Ultan, Harada, Hisashi, Taylor, Shirley M., Morgan, Iain M., Benes, Cyril H., Engelman, Jeffrey A., Mossé, Yael P., Faber, Anthony C.
Published in Cancer cell (08.02.2016)
Published in Cancer cell (08.02.2016)
Get full text
Journal Article
The Ewing Family of Tumors Relies on BCL-2 and BCL-X L to Escape PARP Inhibitor Toxicity
Heisey, Daniel A R, Lochmann, Timothy L, Floros, Konstantinos V, Coon, Colin M, Powell, Krista M, Jacob, Sheeba, Calbert, Marissa L, Ghotra, Maninderjit S, Stein, Giovanna T, Maves, Yuki Kato, Smith, Steven C, Benes, Cyril H, Leverson, Joel D, Souers, Andrew J, Boikos, Sosipatros A, Faber, Anthony C
Published in Clinical cancer research (01.03.2019)
Published in Clinical cancer research (01.03.2019)
Get full text
Journal Article
Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy
Floros, Konstantinos V., Lochmann, Timothy L., Hu, Bin, Monterrubio, Carles, Hughes, Mark T., Wells, Jason D., Morales, Cristina Bernadó, Ghotra, Maninderjit S., Costa, Carlotta, Souers, Andrew J., Boikos, Sosipatros A., Leverson, Joel D., Tan, Ming, Serra, Violeta, Koblinski, Jennifer E., Arribas, Joaquin, Prat, Aleix, Paré, Laia, Miller, Todd W., Dozmorov, Mikhail G., Harada, Hisashi, Windle, Brad E., Scaltriti, Maurizio, Faber, Anthony C.
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2018)
Get full text
Journal Article
Molecular Response of HL-60 Cells to Mitotic Inhibitors Vincristine and Taxol Visualized with Apoptosis-Related Gene Expressions, Including the New Member BCL2L12
Thomadaki, Hellinida, Floros, Konstantinos V., Scorilas, Andreas
Published in Annals of the New York Academy of Sciences (01.08.2009)
Published in Annals of the New York Academy of Sciences (01.08.2009)
Get full text
Journal Article
The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity
Heisey, Daniel A.R., Lochmann, Timothy L., Floros, Konstantinos V., Coon, Colin M., Powell, Krista M., Jacob, Sheeba, Calbert, Marissa L., Ghotra, Maninderjit S., Stein, Giovanna T., Maves, Yuki Kato, Smith, Steven C., Benes, Cyril H., Leverson, Joel D., Souers, Andrew J., Boikos, Sosipatros A., Faber, Anthony C.
Published in Clinical cancer research (01.03.2019)
Published in Clinical cancer research (01.03.2019)
Get full text
Journal Article
Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia
Thomadaki, Hellinida, Floros, Konstantinos V., Pavlovic, Sonja, Tosic, Natasa, Gourgiotis, Dimitrios, Colovic, Milica, Scorilas, Andreas
Published in Clinical biochemistry (01.11.2012)
Published in Clinical biochemistry (01.11.2012)
Get full text
Journal Article