How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity
Cuskin, Fiona, Flint, James E., Gloster, Tracey M., Morland, Carl, Baslé, Arnaud, Henrissat, Bernard, Coutinho, Pedro M., Strazzulli, Andrea, Solovyova, Alexandra S., Davies, Gideon J., Gilbert, Harry J.
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2012)
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Understanding the Biological Rationale for the Diversity of Cellulose-directed Carbohydrate-binding Modules in Prokaryotic Enzymes
Blake, Anthony W., McCartney, Lesley, Flint, James E., Bolam, David N., Boraston, Alisdair B., Gilbert, Harry J., Knox, J. Paul
Published in The Journal of biological chemistry (29.09.2006)
Published in The Journal of biological chemistry (29.09.2006)
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Engineering Hyperthermostability into a GH11 Xylanase Is Mediated by Subtle Changes to Protein Structure
Dumon, Claire, Varvak, Alexander, Wall, Mark A., Flint, James E., Lewis, Richard J., Lakey, Jeremy H., Morland, Carl, Luginbühl, Peter, Healey, Shaun, Todaro, Thomas, DeSantis, Grace, Sun, May, Parra-Gessert, Lilian, Tan, Xuqiu, Weiner, David P., Gilbert, Harry J.
Published in The Journal of biological chemistry (15.08.2008)
Published in The Journal of biological chemistry (15.08.2008)
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Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function
Montanier, Cedric, van Bueren, Alicia Lammerts, Dumon, Claire, Flint, James E, Correia, Marcia A, Prates, Jose A, Firbank, Susan J, Lewis, Richard J, Grondin, Gilles G, Ghinet, Mariana G, Gloster, Tracey M, Herve, Cecile, Knox, J. Paul, Talbot, Brian G, Turkenburg, Johan P, Kerovuo, Janne, Brzezinski, Ryszard, Fontes, Carlos M.G.A, Davies, Gideon J, Boraston, Alisdair B, Gilbert, Harry J
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2009)
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Understanding the Structural Basis for Substrate and Inhibitor Recognition in Eukaryotic GH11 Xylanases
Vardakou, Maria, Dumon, Claire, Murray, James W., Christakopoulos, Paul, Weiner, David P., Juge, Nathalie, Lewis, Richard J., Gilbert, Harry J., Flint, James E.
Published in Journal of molecular biology (01.02.2008)
Published in Journal of molecular biology (01.02.2008)
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Circular Permutation Provides an Evolutionary Link between Two Families of Calcium-dependent Carbohydrate Binding Modules
Montanier, Cedric, Flint, James E., Bolam, David N., Xie, Hefang, Liu, Ziyuan, Rogowski, Artur, Weiner, David P., Ratnaparkhe, Supriya, Nurizzo, Didier, Roberts, Shirley M., Turkenburg, Johan P., Davies, Gideon J., Gilbert, Harry J.
Published in The Journal of biological chemistry (08.10.2010)
Published in The Journal of biological chemistry (08.10.2010)
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The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions
Montanier, Cedric, Money, Victoria A, Pires, Virginia M R, Flint, James E, Pinheiro, Benedita A, Goyal, Arun, Prates, José A M, Izumi, Atsushi, Stålbrand, Henrik, Morland, Carl, Cartmell, Alan, Kolenova, Katarina, Topakas, Evangelos, Dodson, Eleanor J, Bolam, David N, Davies, Gideon J, Fontes, Carlos M G A, Gilbert, Harry J
Published in PLoS biology (01.03.2009)
Published in PLoS biology (01.03.2009)
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Signature Active Site Architectures Illuminate the Molecular Basis for Ligand Specificity in Family 35 Carbohydrate Binding Module
Correia, Márcia A. S, Abbott, D. Wade, Gloster, Tracey M, Fernandes, Vânia O, Prates, José A. M, Montanier, Cedric, Dumon, Claire, Williamson, Michael P, Tunnicliffe, Richard B, Liu, Ziyuan, Flint, James E, Davies, Gideon J, Henrissat, Bernard, Coutinho, Pedro M, Fontes, Carlos M. G. A, Gilbert, Harry J
Published in Biochemistry (Easton) (27.07.2010)
Published in Biochemistry (Easton) (27.07.2010)
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Affinity maturation generates greatly improved xyloglucan-specific carbohydrate binding modules
von Schantz, Laura, Gullfot, Fredrika, Scheer, Sebastian, Filonova, Lada, Cicortas Gunnarsson, Lavinia, Flint, James E, Daniel, Geoffrey, Nordberg-Karlsson, Eva, Brumer, Harry, Ohlin, Mats
Published in BMC biotechnology (31.10.2009)
Published in BMC biotechnology (31.10.2009)
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Understanding How Diverse β-Mannanases Recognize Heterogeneous Substrates
Tailford, Louise E, Ducros, Valerie M.-A, Flint, James E, Roberts, Shirley M, Morland, Carl, Zechel, David L, Smith, Nicola, Bjo̷rnvad, Mads E, Borchert, Torben V, Wilson, Keith S, Davies, Gideon J, Gilbert, Harry J
Published in Biochemistry (Easton) (28.07.2009)
Published in Biochemistry (Easton) (28.07.2009)
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Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase
Nielsen, Morten M., Suits, Michael D.L., Yang, Min, Barry, Conor S., Martinez-Fleites, Carlos, Tailford, Louise E., Flint, James E., Dumon, Claire, Davis, Benjamin G., Gilbert, Harry J., Davies, Gideon J.
Published in The Journal of biological chemistry (29.04.2011)
Published in The Journal of biological chemistry (29.04.2011)
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A Novel, Noncatalytic Carbohydrate-binding Module Displays Specificity for Galactose-containing Polysaccharides through Calcium-mediated Oligomerization
Montanier, Cedric Y., Correia, Márcia A.S., Flint, James E., Zhu, Yanping, Baslé, Arnaud, McKee, Lauren S., Prates, José A.M., Polizzi, Samuel J., Coutinho, Pedro M., Lewis, Richard J., Henrissat, Bernard, Fontes, Carlos M.G.A., Gilbert, Harry J.
Published in The Journal of biological chemistry (24.06.2011)
Published in The Journal of biological chemistry (24.06.2011)
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Crystal Structure of a Cellulosomal Family 3 Carbohydrate Esterase from Clostridium thermocellum Provides Insights into the Mechanism of Substrate Recognition
Correia, Márcia A.S., Prates, José A.M., Brás, Joana, Fontes, Carlos M.G.A., Newman, Joseph A., Lewis, Richard J., Gilbert, Harry J., Flint, James E.
Published in Journal of molecular biology (23.05.2008)
Published in Journal of molecular biology (23.05.2008)
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The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions: e1000071
Montanier, Cedric, Money, Victoria A, Pires, Virginia MR, Flint, James E, Pinheiro, Benedita A, Goyal, Arun, Prates, José AM, Izumi, Atsushi, Stålbrand, Henrik, Morland, Carl, Cartmell, Alan, Kolenova, Katarina, Topakas, Evangelos, Dodson, Eleanor J, Bolam, David N, Davies, Gideon J, Fontes, M GA, Gilbert, Harry J
Published in PLoS biology (01.03.2009)
Published in PLoS biology (01.03.2009)
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Journal Article
The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions
Montanier, Cédric, Money, Victoria A, Pires, Virginia M R, Flint, James E, Pinheiro, Benedita A, Goyal, Arun, Prates, José A M, Izumi, Atsushi, Stålbrand, Henrik, Morland, Carl, Cartmell, Alan, Kolenova, Katarina, Topakas, Evangelos, Dodson, Eleanor J, Bolam, David N, Fontes, Carlos M G A
Published in Plos Biology 3 (7), 687-697. (2009) (2009)
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Published in Plos Biology 3 (7), 687-697. (2009) (2009)
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Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function
Montanier, Cédric, van Bueren, Alicia Lammerts, Dumon, Claire, Flint, James E, Correia, Marcia A, Prates, Jose A, Firbank, Susan J, Lewis, Richard J, Grondin, Gilles G, Ghinet, Mariana G, Gloster, Tracey M, Herve, Cecile, Knox, J Paul, Talbot, Brian G, Turkenburg, Johan P, Kerovuo, Janne, Brzezinski, Ryszard, Fontes, Carlos M G A, Davies, Gideon J
Published in Proceedings of the National Academy of Sciences of the United States of America 9 (106), 3065-3070. (2009) (2009)
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Published in Proceedings of the National Academy of Sciences of the United States of America 9 (106), 3065-3070. (2009) (2009)
Publication
The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions
Montanier, Cédric, Money, Victoria A, Pires, Virginia M R, Flint, James E, Pinheiro, Benedita A, Goyal, Arun, Prates, José A M, Izumi, Atsushi, Stålbrand, Henrik, Morland, Carl, Cartmell, Alan, Kolenova, Katarina, Topakas, Evangelos, Dodson, Eleanor J, Bolam, David N, Fontes, Carlos M G A
Published in Plos Biology 3 (7), 687-697. (2009) (2009)
Get more information
Published in Plos Biology 3 (7), 687-697. (2009) (2009)
Publication
Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function
Montanier, Cédric, van Bueren, Alicia Lammerts, Dumon, Claire, Flint, James E, Correia, Marcia A, Prates, Jose A, Firbank, Susan J, Lewis, Richard J, Grondin, Gilles G, Ghinet, Mariana G, Gloster, Tracey M, Herve, Cecile, Knox, J Paul, Talbot, Brian G, Turkenburg, Johan P, Kerovuo, Janne, Brzezinski, Ryszard, Fontes, Carlos M G A, Davies, Gideon J
Published in Proceedings of the National Academy of Sciences of the United States of America 9 (106), 3065-3070. (2009) (2009)
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Published in Proceedings of the National Academy of Sciences of the United States of America 9 (106), 3065-3070. (2009) (2009)
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