The kinome 'at large' in cancer
Fleuren, Emmy D. G., Zhang, Luxi, Wu, Jianmin, Daly, Roger J.
Published in Nature reviews. Cancer (01.02.2016)
Published in Nature reviews. Cancer (01.02.2016)
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Journal Article
Expression and clinical relevance of MET and ALK in Ewing sarcomas
Fleuren, Emmy D.G., Roeffen, Melissa H.S., Leenders, William P., Flucke, Uta E., Vlenterie, Myrella, Schreuder, Hendrik W., Boerman, Otto C., Graaf, Winette T.A., Versleijen‐Jonkers, Yvonne M.H.
Published in International journal of cancer (15.07.2013)
Published in International journal of cancer (15.07.2013)
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Targeting the FAK-Src Complex in Desmoplastic Small Round Cell Tumors, Ewing Sarcoma, and Rhabdomyosarcoma
van Erp, Anke E. M., Hillebrandt-Roeffen, Melissa H. S., van Bree, Niek F. H. N., Plüm, Tim A., Flucke, Uta. E., Desar, Ingrid M. E., Fleuren, Emmy D. G., van der Graaf, Winette T. A., Versleijen-Jonkers, Yvonne M. H.
Published in Sarcoma (12.05.2022)
Published in Sarcoma (12.05.2022)
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Journal Article
Temsirolimus combined with cisplatin or bevacizumab is active in osteosarcoma models
Fleuren, Emmy D.G., Versleijen‐Jonkers, Yvonne M.H., Roeffen, Melissa H.S., Franssen, Gerben M., Flucke, Uta E., Houghton, Peter J., Oyen, Wim J.G., Boerman, Otto C., Graaf, Winette T.A.
Published in International journal of cancer (15.12.2014)
Published in International journal of cancer (15.12.2014)
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Journal Article
Precision-guided treatment in high-risk pediatric cancers
Lau, Loretta M. S., Khuong-Quang, Dong-Anh, Mayoh, Chelsea, Wong, Marie, Barahona, Paulette, Ajuyah, Pamela, Senapati, Akanksha, Nagabushan, Sumanth, Sherstyuk, Alexandra, Altekoester, Ann-Kristin, Fuentes-Bolanos, Noemi A., Yeung, Veronica, Sullivan, Ashleigh, Omer, Natacha, Diamond, Yonatan, Jessop, Sophie, Battaglia, Lauren, Zhukova, Nataliya, Cui, Louise, Lin, Angela, Gifford, Andrew J., Fleuren, Emmy D. G., Dalla-Pozza, Luciano, Moore, Andrew S., Khaw, Seong-Lin, Eisenstat, David D., Gottardo, Nicholas G., Wood, Paul J., Tapp, Heather, Alvaro, Frank, McCowage, Geoffrey, Nicholls, Wayne, Hansford, Jordan R., Manoharan, Neevika, Kotecha, Rishi S., Mateos, Marion K., Lock, Richard B., Tyrrell, Vanessa, Haber, Michelle, Trahair, Toby N., Cowley, Mark J., Ekert, Paul G., Marshall, Glenn M., Ziegler, David S.
Published in Nature medicine (01.07.2024)
Published in Nature medicine (01.07.2024)
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The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis
Murray, Jayne E., Valli, Emanuele, Milazzo, Giorgio, Mayoh, Chelsea, Gifford, Andrew J., Fletcher, Jamie I., Xue, Chengyuan, Jayatilleke, Nisitha, Salehzadeh, Firoozeh, Gamble, Laura D., Rouaen, Jourdin R. C., Carter, Daniel R., Forgham, Helen, Sekyere, Eric O., Keating, Joanna, Eden, Georgina, Allan, Sophie, Alfred, Stephanie, Kusuma, Frances K., Clark, Ashleigh, Webber, Hannah, Russell, Amanda J., de Weck, Antoine, Kile, Benjamin T., Santulli, Martina, De Rosa, Piergiuseppe, Fleuren, Emmy D. G., Gao, Weiman, Wilkinson-White, Lorna, Low, Jason K. K., Mackay, Joel P., Marshall, Glenn M., Hilton, Douglas J., Giorgi, Federico M., Koster, Jan, Perini, Giovanni, Haber, Michelle, Norris, Murray D.
Published in Nature communications (11.07.2024)
Published in Nature communications (11.07.2024)
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Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients
Vlenterie, Myrella, Hillebrandt-Roeffen, Melissa H. S., Schaars, Esther W. M., Flucke, Uta E., Fleuren, Emmy D. G., Navis, Anna C., Leenders, William P. J., Versleijen-Jonkers, Yvonne M. H., van der Graaf, Winette T. A.
Published in Annals of surgical oncology (01.09.2016)
Published in Annals of surgical oncology (01.09.2016)
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Journal Article
ATR Is a Therapeutic Target in Synovial Sarcoma
Jones, Samuel E, Fleuren, Emmy D G, Frankum, Jessica, Konde, Asha, Williamson, Chris T, Krastev, Dragomir B, Pemberton, Helen N, Campbell, James, Gulati, Aditi, Elliott, Richard, Menon, Malini, Selfe, Joanna L, Brough, Rachel, Pettitt, Stephen J, Niedzwiedz, Wojciech, van der Graaf, Winette T A, Shipley, Janet, Ashworth, Alan, Lord, Christopher J
Published in Cancer research (Chicago, Ill.) (15.12.2017)
Published in Cancer research (Chicago, Ill.) (15.12.2017)
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Journal Article
Targeted Therapy-based Combination Treatment in Rhabdomyosarcoma
van Erp, Anke E M, Versleijen-Jonkers, Yvonne M H, van der Graaf, Winette T A, Fleuren, Emmy D G
Published in Molecular cancer therapeutics (01.07.2018)
Published in Molecular cancer therapeutics (01.07.2018)
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Journal Article
Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes
Fleuren, Emmy D G, Vlenterie, Myrella, van der Graaf, Winette T A, Hillebrandt-Roeffen, Melissa H S, Blackburn, James, Ma, Xiuquan, Chan, Howard, Magias, Mandy C, van Erp, Anke, van Houdt, Laurens, Cebeci, Sabri A S, van de Ven, Amy, Flucke, Uta E, Heyer, Erin E, Thomas, David M, Lord, Christopher J, Marini, Kieren D, Vaghjiani, Vijesh, Mercer, Tim R, Cain, Jason E, Wu, Jianmin, Versleijen-Jonkers, Yvonne M H, Daly, Roger J
Published in Cancer research (Chicago, Ill.) (15.08.2017)
Published in Cancer research (Chicago, Ill.) (15.08.2017)
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Enhancing the Potential of Immunotherapy in Paediatric Sarcomas: Breaking the Immunosuppressive Barrier with Receptor Tyrosine Kinase Inhibitors
Fleuren, Emmy D G, Terry, Rachael L, Meyran, Deborah, Omer, Natacha, Trapani, Joseph A, Haber, Michelle, Neeson, Paul J, Ekert, Paul G
Published in Biomedicines (30.11.2021)
Published in Biomedicines (30.11.2021)
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Journal Article
Predicting IGF-1R Therapy Response in Bone Sarcomas: Immuno-SPECT Imaging with Radiolabeled R1507
FLEUREN, Emmy D. G, VERSLEIJEN-JONKERS, Yvonne M. H, VAN DER GRAAF, Winette T. A, VAN DE LUIJTGAARDEN, Addy C. M, MOLKENBOER-KUENEN, Janneke D. M, HESKAMP, Sandra, ROEFFEN, Melissa H. S, VAN LAARHOVEN, Hanneke W. M, HOUGHTON, Peter J, OYEN, Wim J. G, BOERMAN, Otto C
Published in Clinical cancer research (15.12.2011)
Published in Clinical cancer research (15.12.2011)
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Journal Article
Theranostic applications of antibodies in oncology
Fleuren, Emmy D.G., Versleijen-Jonkers, Yvonne M.H., Heskamp, Sandra, van Herpen, Carla M.L., Oyen, Wim J.G., van der Graaf, Winette T.A., Boerman, Otto C.
Published in Molecular oncology (01.06.2014)
Published in Molecular oncology (01.06.2014)
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Journal Article
Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development
Fleuren, Emmy D.G., O'Toole, Sandra, Millar, Ewan K., McNeil, Catriona, Lopez‐Knowles, Elena, Boulghourjian, Alice, Croucher, David R., Schramek, Daniel, Brummer, Tilman, Penninger, Josef M., Sutherland, Robert L., Daly, Roger J.
Published in International journal of cancer (15.09.2010)
Published in International journal of cancer (15.09.2010)
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Journal Article
Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer
Wong, Marie, Mayoh, Chelsea, Lau, Loretta M. S., Khuong-Quang, Dong-Anh, Pinese, Mark, Kumar, Amit, Barahona, Paulette, Wilkie, Emilie E., Sullivan, Patricia, Bowen-James, Rachel, Syed, Mustafa, Martincorena, Iñigo, Abascal, Federico, Sherstyuk, Alexandra, Bolanos, Noemi A., Baber, Jonathan, Priestley, Peter, Dolman, M. Emmy M., Fleuren, Emmy D. G., Gauthier, Marie-Emilie, Mould, Emily V. A., Gayevskiy, Velimir, Gifford, Andrew J., Grebert-Wade, Dylan, Strong, Patrick A., Manouvrier, Elodie, Warby, Meera, Thomas, David M., Kirk, Judy, Tucker, Katherine, O’Brien, Tracey, Alvaro, Frank, McCowage, Geoffry B., Dalla-Pozza, Luciano, Gottardo, Nicholas G., Tapp, Heather, Wood, Paul, Khaw, Seong-Lin, Hansford, Jordan R., Moore, Andrew S., Norris, Murray D., Trahair, Toby N., Lock, Richard B., Tyrrell, Vanessa, Haber, Michelle, Marshall, Glenn M., Ziegler, David S., Ekert, Paul G., Cowley, Mark J.
Published in Nature medicine (01.11.2020)
Published in Nature medicine (01.11.2020)
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Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
Brummer, Tilman, Larance, Mark, Abreu, Maria Teresa Herrera, Lyons, Ruth J, Timpson, Paul, Emmerich, Christoph H, Fleuren, Emmy DG, Lehrbach, Gillian M, Schramek, Daniel, Guilhaus, Michael, James, David E, Daly, Roger J
Published in The EMBO journal (03.09.2008)
Published in The EMBO journal (03.09.2008)
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Journal Article
Directing the use of DDR kinase inhibitors in cancer treatment
Brandsma, Inger, Fleuren, Emmy D G, Williamson, Chris T, Lord, Christopher J
Published in Expert opinion on investigational drugs (02.12.2017)
Published in Expert opinion on investigational drugs (02.12.2017)
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